@ToiberDebbie

Molecular Biologist, DNA repair, sirtuins, ageing and Neurodegeneration

Joined March 2017
  • Tweets285
  • Following326
  • Followers469
28Media
Debbie Toiber retweeted
Literary Titan@LiteraryTitanJan 27
Genluminati follows a group of young scientists who invent a DNA-based religion as a cynical experiment—only to lose control of it when belief spreads, and a prophet emerges. Did the concept begin as #satire for you, or did you always see it turning dark? wp.me/p3cyvH-LYH?utm_campaig…
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🟠 For the full article>> nature.com/articles/s41467-0…

Histone deacetylase SIRT6 regulates tryptophan catabolism and prevents metabolite imbalance...

Nature Communications - Tryptophan metabolism is disrupted in aging and neurological disorders. Here, the authors show that histone deacetylase sirtuin 6 regulates tryptophan usage, and its absence...

nature.com
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what am I up to? reading @ToiberDebbie 's new book of course
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Replying to @TwoSenzuBeans @ToiberDebbie @BarakRotblat @bengurionu
Link to the episode on Spotify open.spotify.com/episode/2br…

Episode 22: Prof. Dr. Björn Schumacher

ביולוגיה ללא-ביולוגים · Episode

open.spotify.com
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We’re excited to unveil our new joint work (with @ToiberDebbie and many fantastic collaborators) on how pharmacological activation of SIRT6 (via MDL-800) reshapes tumor metabolism and blocks tumor growth in HNSCC & ESCC models. @SpringerNature rdcu.be/eLBPC
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🧬🧬🧬Targeting Genome Stability to Mitigate Human Aging and Disease - read now our comprehensive article written with @ToiberDebbie how we can target the most fundamental mechanisms of aging and cancer. @AnnualReviews 🔗 go.shr.lc/3JohYMp
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Debbie Toiber retweeted
Adam@molecular_guy7 Nov 2024
First paper published! Our work defines a novel regulatory switch on neural gene expression, dependent on SIRT6 existence. It was a great opportunity to do this work under the supervision of @ToiberDebbie and the exceptional help of her lab. nature.com/articles/s41419-0…

SIRT6-dependent functional switch via K494 modifications of RE-1 silencing transcription factor

Cell Death & Disease - SIRT6-dependent functional switch via K494 modifications of RE-1 silencing transcription factor

nature.com
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#Postdoc Opportunity: Do you love #mechanobiology, #microscopy, and #cellmigration? Join our team at @CornellBME and @weillinstitute to investigate how cells squeeze their nucleus through tight spaces and how this affects nuclear structure and function. tinyurl.com/mechanobiology-p…
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✅Featuring our cover on Stochasticity in Aging at @NatureAging designed by the amazing @maayanvisuals. Read our groundbreaking article nature.com/nataging Aging clocks based on accumulating stochastic variation. Huge congrats to @Meyer_DH @CECAD_ @UKKoeln @UniCologne
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Our new @biorxivpreprint in out ✨ We adopted concepts from anomaly detection to improve representations of high-content image-based phenotypic profiling while maintaining them biologically-interpretable! biorxiv.org/content/10.1101/… 🧵 1/9

Anomaly detection for high-content image-based phenotypic cell profiling

High-content image-based phenotypic profiling combines automated microscopy and analysis to identify phenotypic alterations in cell morphology and provide insight into the cell’s physiological state....

biorxiv.org
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Debbie Toiber retweeted
David Meyer@Meyer_DH29 May 2024
Read our new paper about different neuronal aging rates! 🧠 And discover how we identified new compounds that might be key for neuroprotection. 🔬 🫐 #Neuroscience #Aging #Biotech (1/5)
Björn Schumacher@schumacherbj29 May 2024
🔥🔥🔥Neuron-type specific aging-rate reveals age decelerating interventions preventing neurodegeneration. 🧠🧠🧠Read here our latest super exciting #preprint on @researchsquare Congrats to @Meyer_DH and @CGallrein researchsquare.com/article/r…
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🔥🔥🔥my 💯 paper is out, congrats 🎈🎉🍾 @Meyer_DH for this amazing story. Aging clocks tick by the noise: we can build aging clocks 🕰️ on accumulating stochastic variation! @CECAD_ @UniCologne @CGA_age @UKKoeln follow 🧵retweet & read now open access: nature.com/articles/s43587-0…

Aging clocks based on accumulating stochastic variation

Nature Aging - Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological and biological age, sensitive...

nature.com
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🔥🔥🔥Read now our latest review on: 🧬DNA repair deficiencies and 🧠neurodegeneration by Baptiste Ropert and Christian Gallrein sciencedirect.com/science/ar…
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Debbie Toiber retweeted
Barak Rotblat@BarakRotblat4 Jan 2024
פודקסט חדש של הקורס ביולוגיה ללא ביולוגים🎙️ פרופ" דבי טויבר @ToiberDebbie ואני שוחחנו עם ד"ר שי פילוסוף @shaipilo על איך משלבים אהבה לטיולים ותכנות. שי משתמש במדע של רשתות ועונה על שאלות באקולוגיה🐝🐸🌸 לד"ר בוזי רביד והאולפן הכייפי שלו🙏 @bengurionu radiopublic.com/-60Z5kN/s1!a…
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Our documentary film about the ancient Hertiage Yeast (see below) has won the award of the best documentary film in the "Feel the Reel" competition at the Glasgow Film Festival. youtube.com/watch?v=t6trxxMj… feelthereeliff.com/may-2023/

Resurrecting Ancient Beer: Archaeologists, Biologists and Brewers...

Making up for lost time (Full Film)Winner of Best Documentary - F...

youtube.com
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We feature the outstanding recent work on Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality by @yetianmed @AndreaBMaier @AndrewZalesky nature.com/articles/s41591-0…

Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality

Nature Medicine - Organ-specific aging clocks for multiple brain and body systems show that the biological age of one organ system selectively influences the aging of multiple other systems via...

nature.com
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Debbie Toiber retweeted
Eran Meshorer@meshorer11 May 2023
Post-doc position available in our lab. Come join us! Please RT! meshorerlab.huji.ac.il/ elsc.huji.ac.il/people-direc… @HebrewU @GeneticsDepart1 @ELSCbrain @HebrewU_heb @AmFriendsHU
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Debbie Toiber retweeted
SteinbergLab@SteinbergLab2 Apr 2023
The dancing vortices - see my previous tweet on our new vortex-control devices allowing, for the first time, to see vortex-braiding! pubs.acs.org/doi/10.1021/acs…
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Debbie Toiber retweeted
Barak Rotblat@BarakRotblat1 Apr 2023
פודקאסט עם @ToiberDebbie , איך יוצרים תאי גזע מתאים של בוגרים? האם אפיגנטיקה יכולה ללמד אותנו על נאנדרטאלים? תודה לפורפ' ערן משורר @meshorer1 על השיחה המרתקת! 🙏 open.spotify.com/episode/1pG…

פרק 17: פרופ' ערן משורר

ביולוגיה ללא-ביולוגים · Episode

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Our DREAM paper is out: We found the first master regulator of DNA repair capacities! Read and re-tweet now: The DREAM complex functions as conserved master regulator of somatic DNA repair capacities, @CECAD_ @UKKoeln @UniCologne nature.com/articles/s41594-0…

The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities

Nature Structural & Molecular Biology - In this work, the authors show that the DREAM complex suppresses the expression of numerous DNA-repair proteins in somatic cells. Suppression of the...

nature.com
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