🩸 a podcast about heme/onc for health care providers | ☕️ short high yield episodes to supplement your board review resources | @SamArmstrongMD @DrKarineTawagi

Joined June 2022
🤔 Heading to #ASH26? ⭐️ Join us for a complimentary in-person Hematology Board Review for fellows & anyone prepping for boards 🩸 📅 Friday, December 11, 2026 🕗 8:00 AM–12:00 PM CT 📍 420 Julia St., New Orleans, LA 🔗 Register: bit.ly/hemeboards
🤖 Made with AI
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Excited to join the Clinicals to Exam – Oncology Board Review during #ASH2026 in New Orleans on December 11! Looking forward to strengthening my clinical knowledge, gaining valuable insights, and connecting with fellow hematology/oncology professionals! #HemeOnc #Oncology #MedEd @OncUpdates @OncBrothers @TwoOncDocs #hematology OncologyBrothers.regfox.com/…
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We are back this week with our final #breastcancer series on metastatic breast cancer 🩷 A 62yo F presents with newly diagnosed ER-positive, HER2-negative metastatic breast cancer with asymptomatic bone and nodal disease. Which of the following is a preferred tx?
4%Letrozole alone
2%Paclitaxel
92%Aromatase inh+ ribociclib
2%Fulvestrant
53 votes • Final results
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C) In the NCCN the preferred 1L therapy for HR-positive, HER2-negative recurrent/metastatic disease is an AI combined with a CDK4/6 inhibitor; among these, the AI + ribociclib combination is specifically designated category 1, based on the OS benefit shown in the MONALEESA trials
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TwoOncDocs retweeted
🤩 #HemOnc Fellows, are you going to #ASH26? Join for a FREE board review! 👀 Here is a sneak peek of your board review day! 🗓️ In-person w/@OncBrothers + @TwoOncDocs 🔗 Register: bit.ly/hemeboards #OncTwitter #MedX #MedTwitter #ASH @HemOncFellows @hemeoncfellow
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TwoOncDocs retweeted
🤔Headed to #ASH26? Join for a FREE board review! 🗓️ In-person w/@OncBrothers + @TwoOncDocs 📅 Friday, Dec 11th 📍 Common House,New Orleans 🔗 Register: bit.ly/hemeboards #OncTwitter #HemOnc #MedX #MedTwitter #ASH #MedEd @HemOncFellows @hemeoncfellow @ASH_hematology
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Highly recommended! 💕 2026 update focusing on metastatic breast cancer @TwoOncDocs There is no better way to learn new Oncology meds other than treat them like new songs (listen frequently) 🎶 Learn from the BEST on proper pronunciations of Onc meds. podcasts.apple.com/us/podcas…
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Today part 2 of our breast cancer series is out on Localized #BreastCancer 🩷 A 39yo woman with pt1c (1.5cm) ER+ breast cancer undergoes a lumpectomy with SLNB. Which of the following adjuvant endocrine therapies is preferred in PRE menopausal women?
0%Anastrozole alone
4%Letrozole alone
96%Tamoxifen +/- OFS
0%Fulvestrant alone
26 votes • Final results
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Answer is C) Tamoxifen for 5 years (with or without ovarian function suppression. The addition of OFS to tamoxifen (or use of an AI plus OFS) is reserved for patients at higher risk - young age (≤35–40 years), high grade, or nodal involvement -based on the SOFT and TEXT trials.
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We are back with 2026 Breast Cancer updates! 🩷 In today’s episode, we cover an introduction on breast cancer, screening, prevention, DCIS, LCIS & more. At what age range, should patients with triple negative breast cancer have genetic testing?
35%30-45yo
0%45-60yo
0%60+yo
65%All patients with TNBC
26 votes • Final results
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The answer is D) all patients with TNBC should undergo germline testing
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Today 9/24/26 new approval in 2L clear cell mRCC with some caveats #LITESPARK011 💢 4mo PFS gain, higher ORR (53% vs 40%) & DOR (23 v 12mo) 💢 OS is not yet significant 💢 how does it perform post 1L IO/IO vs IO/TKI, weight of extra toxicity & optimal sequencing still unclear
Based off LITESPARK-011: Belzutifan + Lenvatinib is now @FDA ✅ in 2L RCC after IO exposure: PhIII: Bel + Len vs. Cabo - mPFS 14.6mos vs. 10.7mos (HR: 0.74) - mOS 33.7mos vs. 28.6mos (HR: 0.85, p=0.061). - AEs: 72% vs. 66% w/ Gr ≥ 3 #OncTwitter #gusm @OncUpdates
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Highly recommended: @TwoOncDocs Yes for Pharmacy students as well
Localized NSCLC in 2026: new staging, expanded perioperative options, and a driver-directed pathway that reshapes management. The Two Onc Docs deliver the high-yield takeaways, tune in now! 🎙️Full episode: hubs.li/Q04xhhFv0
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So exciting to see the FDA approval for this today ‼️‼️
Standing ovation for a ***breakthrough*** in #pancreaticcancer 🥹🥹🥹 #RASolute today presented at #ASCO26: Daraxonrasib DOUBLES the median overall survival in metastatic pancreatic cancer w/ +w/o RAS (mOS 13.2 mo vs. 6.6 mo) A HUGE advance in one of the most lethal cancers 💜
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New episode out today updating Iron Overload Syndromes! 🩸 A 52M is found to have an elevated ferritin and a transferrin saturation of 60%. Genetic testing confirms C282Y homozygosity. Which is the most appropriate 1L treatment? @HemOncFellows #hematology #boardreview
14%Deferasirox
83%Therapeutic phlebotomy
3%Deferoxamine
0%Liver transplantation
35 votes • Final results
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The answer is B) Phlebotomy is 1L for HFE hereditary hemochromatosis, w/ target ferritin of 50–100 μg/L then maintenance near ~50 μg/L.  Oral/parenteral chelators (deferasirox, deferoxamine) -> for those who cannot tolerate phlebotomy or have 2ary/transfusional iron overload
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TwoOncDocs retweeted
Great work Well worth listening to @OpenMedicineHQ
Burnout is extremely prevalent in medicine & specifically in oncology - in this week’s episode we discuss Wellness in Oncology tips w/ @doclauravater & the SMILE Scale - a wellness behavioral tool designed to measure and encourage healthy habits ❤️‍🩹 podcasts.apple.com/us/podcas…
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We love ourselves a @thefellowoncall x @TwoOncDocs! Thank you @wimedicineorg #COSMO2026 for inviting us to present our workshop “Build, Connect, Rise: Education, Mentorship and Career Development in the Digital Age of Oncology”! – at Chicago, IL
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RT @DrKarineTawagi: 📣 FDA approval of Pluvicto triplet vs ADT/ARPI for mCSPC (APMS) vs ADT/ARPI #PSMAddition ✔️ rPFS: HR 0.72 ✔️ time to m…
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TwoOncDocs retweeted
🎙️ New episode alert: Samantha A. Armstrong, MD, and Karine Tawagi, MD break down DLBCL presentation on Two Onc Docs, from classic B symptoms to the 30-40% of cases with GI, CNS, or thyroid involvement, and why excisional biopsy is required. 🔬 Access the full OncLive® episode: hubs.li/Q04qyRzH0 @TwoOncDocs @SamArmstrongMD @DrKarineTawagi #DLBCL #Lymphoma #HemOnc
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