Scott E Delacroix Jr M.D. retweeted
DASL-HiCaP: darolutamide on top of 96 weeks of ADT plus RT improved MFS in very high-risk localized prostate cancer, HR 0.42, 4-yr MFS 95% vs 88%.
📈 n=1,106, interim at 67% of events, 46 mo follow-up. OS immature
📝 Thanks to @Silke_Gillessen putting this into context STAMPEDE M0 (HR 0.53) and ENZARAD (HR 0.88): not contradictory, the ARPI benefit tracks metastatic risk
🎯 N1 is the clearest indication. N0 is less clear, and Gleason seems to matter
Every patient got pelvic RT, so who needs it in N0 not yet answered.
@Niazi_Dr7 #ProstateCancer #GUonc #ESMO26
Thrilled to share updated results from JNJ-6143, the AR-BRD4 RIPTAC therapy, presented by @BGarmezy. Totally novel MOA was well tolerated, oral pill and produced significant benefit for pts (PSA90 50%, ORR 68%). P2 trial active now and more coming. Lots of potential!
Scott E Delacroix Jr M.D. retweeted
JNJ-6143, first-in-class oral AR-BRD4 RIPTAC, phase 1 mCRPC: a wide window between efficacy and safety. n=105, doses 12.5 to 150 mg.
📈 50 mg daily: PSA50 77%, PSA90 48%, confirmed ORR 69%, after a median 4 prior lines
📊 PSA declines seen from 12.5 to 150 mg. 66% of all patients still on drug
🔍 At 50 mg: 58% any-grade TRAEs, no serious TRAEs. Median DOR 11.0 months, CI 5.9 to NE
Activity across a 12-fold dose range. Phase 2 is open at 50 mg.
Congrats to @BGarmezy on the presentation and all the investigators.
#ESMO26 #ProstateCancer #mCRPC #GUonc
Scott E Delacroix Jr M.D. retweeted
Huge milestone as the ARCHER study hits 100 patients! 🎉
It’s evaluating if 5 sessions of high-dose SBRT can shorten radiation and preserve the bladder in MIBC.
Proud to share the explainer video we created to help explain the trial below!
primrmed.com/cancer-clinical…
Scott E Delacroix Jr M.D. retweeted
Outstanding and provocative (🤩🤩on-brand) overview of advances in NMIBC from @DrMBWesterman #Shea26
Scott E Delacroix Jr M.D. retweeted
Meet the 2026–2027 SESAUA Board of Directors, led by President Paul W. F. Coughlin, MD, FACS. Thank you to our leaders for guiding the Section this year. sesaua.org/about/board-of-di… #SESAUA #Urology
Scott E Delacroix Jr M.D. retweeted
🚨 #ARCHER @NRGonc GU 15 AMENDMENT
✅ Neoadjuvant and Adjuvant Therapy Explicitly Allowed
✅ TURBT→enrollment: 240 days with ≥3 NAT cycles
✅ Week-16 biopsy only if indicated
✅ Less frequent surveillance after year 2
✅ Local chemo/telehealth
✅ Updated adaptive RT/QA + utDNA collection
Same trial: 20 vs 5 fractions. #BladderCancer
#ASTRO26 @ASTRO_org
@UroCancer @drjefstathiou @SeanSachdevMD @ndesai2005 @l_ballas @IyerGopa @Dr_Aggen @shilpaonc @DrMBWesterman @Katie_Spina @MiyamotoDavid @AdityaBagrodia @jonathan_leeman @KashaniRojano @KateMRGuidance @abhiAsolanki
Scott E Delacroix Jr M.D. retweeted
Now published in Practical Radiation Oncology: @ASTRO_org's first clinical practice guideline on radiation therapy for bladder cancer!
The guideline supports trimodal therapy as a curative, bladder-preserving option for appropriately selected patients with muscle-invasive bladder cancer and clarifies radiation’s role after surgery and in advanced disease. Multidisciplinary care and shared decision-making are central throughout.
It was a privilege to co-chair this effort with Leslie Ballas and work with an exceptional multidisciplinary task force, our patient representative, and ASTRO staff. Thank you all for your expertise, collaboration, and dedication to improving bladder cancer care. A tremendous team effort!
Read more: bit.ly/4rcR77D
@ESTRO_RT
@Uroweb
#RadiationOncology #BladderCancer #OncoNews #RadOnc #PracticalRO #GUOncology
Scott E Delacroix Jr M.D. retweeted
allegedly spotted in Birmingham 👀
LSU fans are somethin else man (via @TigerDroppings)
Scott E Delacroix Jr M.D. retweeted
Wife: What did those LSU fans just say?! 😡 your son doesn’t need to hear that!
Me:
EVP MM? Magic-mushroom compound blocks a severe side effect of chemotherapy in mice nature.com/articles/d41586-0…
Scott E Delacroix Jr M.D. retweeted
I’m sorry, but I just can’t help but imagine this scene if Lane Kiffin has to make an appearance.
“I PUT IT TO YOU GREG (SANKEY)!”
"It is a truly surreal scene."
@PeteThamel details the latest on the SEC suing LSU and Lane Kiffin in federal court ✍️














































