Daniel Wacker retweeted
Peer-reviewed version of @filizolalab1’s ‘Mechanism of μ-Opioid Receptor-Magnesium Interaction and Positive Allosteric Modulation’ is now available on @biophysJ - ScienceDirect sciencedirect.com/science/ar…
Daniel Wacker retweeted
EXCITING NEWS! Dr. Denise J. Cai receives prestigious @NIH Director’s New Innovator Award from the @NIH_CommonFund’s High-Risk, High-Reward Research program! A HUGE CONGRATULATIONS to @denisejcai on this great honor!🍾🎉🌟 PRESS RELEASE: ow.ly/tO5y50wycTn
Daniel Wacker retweeted
Online now at Cell: VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells zpr.io/gJjGU
Daniel Wacker retweeted
PRESS RELEASE: Congratulations @rajankdr & Daniel Wacker @wackerlab for being named recipients of the 2019 @SloanFoundation Research Fellowships! This prestigious award & honor recognizes them as among the most promising researchers in their fields! mountsinai.org/about/newsroo…
Daniel Wacker retweeted
Latest paper from @chem4biology and @RothLabUNC in @nature --this is a biggie!
"Here we investigate structure-based docking of 170 million make-on-demand compounds ....we discovered 180-pM subtype-selective agonist of the D4 dopamine receptor."
nature.com/articles/s41586-0…
Daniel Wacker retweeted
For anyone interested in where new drugs come from, here's a comprehensive analysis - it's not new, but it's still relevant rdcu.be/bkbwr
Daniel Wacker retweeted
Crystal structure of rhodopsin in complex with a mini-Go sheds light on the principles of G protein selectivity | Science Advances advances.sciencemag.org/cont…
Daniel Wacker retweeted
How do sodium ions bind to #opioid #gpcr and modulate their activation?
Our latest #MD #MSM #ML study, by Hu et al. @filizolalab1 is out in @PLOSCompBiol. All input files and trajectories are public @OSFramework #reproducibility journals.plos.org/ploscompbi…
Daniel Wacker retweeted
This is yuuge prnewswire.com/news-releases…
Daniel Wacker retweeted
Congratulations to all the #Lasker2018 winners! Read their stories now in @CellCellPress! @LaskerFDN cell.com/cell/lasker-2018
Daniel Wacker retweeted
A new painkiller promises relief without addiction, but there's still lots to do pops.ci/uGMtDW via @PopSci
Daniel Wacker retweeted
Latest paper from @RothLabUNC --a ton of work and what I think is a gem for modern molecular pharmacology.
Video highlights attached...
Structural determinants of 5-HT2B receptor activation and biased agonism
nature.com/articles/s41594-0…
Daniel Wacker retweeted
Four structures of proteins provide clues about how a ubiquitous family of receptors selectively activates different signalling pathways – explained by Michael Capper & Daniel Wacker @WackerLab go.nature.com/2lG3toT
Daniel Wacker retweeted
Great News and Views by @WackerLab --auspicious start!
nature.com/articles/d41586-0…
Daniel Wacker retweeted
Not entirely clear that this is an on-target effect nor that the effect is greater than expected in this particular patient population, but not good news for 5-HT2A mechanism cnn.com/2018/04/09/health/pa…
Daniel Wacker retweeted
Congrats to @Cannabatopia - this amazing guy took home a Young Investigator Award at #ABC2018 😍
Daniel Wacker retweeted
Nice overview of work done by amazing postdocs @Anat_Levit @WackerLab and Sheng Wang (no twitter account)! xitter.cf/nature/status/96930981…
News & Views: The ideal drugs for treating schizophrenia are postulated to selectively block the D2 dopamine receptor with optimum binding kinetics. Reported in Nature, the structure of D2 bound to an antipsychotic sheds light on how to design such drugs go.nature.com/2GUCQoP
Daniel Wacker retweeted
An Adeno-Associated Virus-Based Toolkit for Preferential Targeting and Manipulating Quiescent Neural Stem Cells in the Adult Hippocampus cell.com/stem-cell-reports/a…