Associate Professor & CPRIT scholar @MDAndersonNews studying stress responses in tumor microenvironment and anti-tumor immunity.

Houston, TX
Joined September 2020
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Beautiful work! Congrats, Davide!
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Many congratulations to @LV_Xiangdong who has been awarded the CPRIT scholar award to set up his own lab at @UTHealthHouston! He is amazing!
BREAKING NEWS: #CPRIT approved $89 million in grants to advance the state’s fight against cancer, including CPRIT Scholar recruitment awards, evidence-based prevention programs and innovative companies developing new cancer drugs and treatments.  READ: ow.ly/m9Qg50Ub8qi
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Replying to @JianXuLab
Beautiful work! Congrats, Jian!
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Replying to @JCubRuiz
Beautiful work, congrats, Juan!
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Many congratulations, Jen! Well deserved.
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Thank you @theNAMedicine @MDAndersonNews and all who contribute to our mission to #endcancer - patients and families, care teams, researchers and supporters worldwide. Honored to continue this important work together
Jennifer A. Wargo (@jenwargomd) of @MDAndersonNews was elected as a member of the National Academy of Medicine in 2023. Congratulations and welcome! #NAMclassof2023
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Thanks very much, Costas!
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Replying to @RuggeroDavide
Many thanks, Davide!
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Replying to @JCubRuiz
Thank you, Juan!
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Replying to @SGoswamiMDPhD
Thank you, Sangeeta!
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Thanks #JPAI @JimAllisonPhD @PamSharmaMDPhD @DraettaG Rugang Zhang and @NCICancerBio for support!
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Replying to @VanjaLazarevic5
Thank you, Vanja!
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Kudos to the amazing trainees @LongyongX @FanglueP and all fantastic collaborators!
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Inhibiting IRE1 RNase in TP53-mutant TNBC allows taxane to be highly immunogenic, triggering dsRNA-ZBP1-NLRP3-GSDMD pyroptotic signaling cascade, turning PD-L1-negative cold tumors hot, and conferring these cold tumors hypersensitivity to PD-1 inhibitor.
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Happy to share our latest work showing that an ancient ER-localized RNase IRE1 coordinates with p53 to silence taxane-induced dsRNA and protect immune-cold TNBC from pore-forming pyroptosis. ⁦@CellCellPress⁩ ⁦@MDAndersonNews⁩ cell.com/cell/abstract/S0092…
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Replying to @DavidHongMD
Thank you, David!
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Replying to @JeffMRosen
Congrats, Jeff! So well deserved!
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