
Associate Professor & CPRIT scholar @MDAndersonNews studying stress responses in tumor microenvironment and anti-tumor immunity.
Houston, TX
Joined September 2020
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Many congratulations to @LV_Xiangdong who has been awarded the CPRIT scholar award to set up his own lab at @UTHealthHouston! He is amazing!
BREAKING NEWS: #CPRIT approved $89 million in grants to advance the state’s fight against cancer, including CPRIT Scholar recruitment awards, evidence-based prevention programs and innovative companies developing new cancer drugs and treatments.
READ: ow.ly/m9Qg50Ub8qi
Xi Chen retweeted
Thank you @theNAMedicine @MDAndersonNews and all who contribute to our mission to #endcancer - patients and families, care teams, researchers and supporters worldwide. Honored to continue this important work together
Jennifer A. Wargo (@jenwargomd) of @MDAndersonNews was elected as a member of the National Academy of Medicine in 2023. Congratulations and welcome! #NAMclassof2023
Kudos to the amazing trainees @LongyongX @FanglueP and all fantastic collaborators!
Inhibiting IRE1 RNase in TP53-mutant TNBC allows taxane to be highly immunogenic, triggering dsRNA-ZBP1-NLRP3-GSDMD pyroptotic signaling cascade, turning PD-L1-negative cold tumors hot, and conferring these cold tumors hypersensitivity to PD-1 inhibitor.
Happy to share our latest work showing that an ancient ER-localized RNase IRE1 coordinates with p53 to silence taxane-induced dsRNA and protect immune-cold TNBC from pore-forming pyroptosis. @CellCellPress @MDAndersonNews cell.com/cell/abstract/S0092…




