Zac Germon retweeted
proteomic landscape of diffuse midline glioma highlights the therapeutic potential of non-histone protein methyltransferases academic.oup.com/neuro-oncol…
Had a great day at @TheASMR1 Hunter meeting. Grateful to have been awarded Best ECR/MCR talk on the day!
Thanks Heather, looking forward to it!
On July 18, I'll be hosting @XuDongZhang15 and @ZacGermon at an online seminar for @AEpiA. I'm looking forward to showcasing the work of two great colleagues from @UON_research and @HMRIAustralia . Tune in for some fabulous science and discussion!
Thanks @CancerAustralia & @KidsCancerProj! Excited to be given the opportunity to continue this project investigating much needed novel treatment strategies for Paediatric cancers #AML #DMG #DIPG
Delighted #DunLab 's childhood cancer project was funded by @CancerAustralia & @KidsCancerProj
Free-radicals (#ROS) promote cancer signaling in RTK mutant- #AML & #DMG #DIPG
Here we will develop new targeted treatments
Congrats @ZacGermon @duchatel_ryan @Jonatha16752881 DE & ID
Zac Germon retweeted
Wonderful to see the glossy version & cover of #DunLab’s latest paper discovering the genetic dependency & targeting of PI3K in #DIPG #DMG
Huge thanks to the funders & parents who donated their child’s tissues to help us in this & all our important studies doi.org/10.1172/JCI170329
#Cover: Targeting PI3K/mTOR in diffuse intrinsic pontine glioma: buff.ly/3TAz4Jd
#Image presents a model whereby the connectivity of these cancers can be harnessed using integrated technologies to identify potential therapeutic strategies.
#Oncology #Therapeutics
Congratulations @MattDun17! So well deserved. Your dedication and determination inspire us each day in the fight against kids cancer!
So thankful to receive this prestigious award on behalf of our incredible #DunLab team
May I thank all our #CSRG team & recognise the inspirational scientists that did all the work particularly @evierjackson @duchatel_ryan @AliciaD0uglas @DilanaStaudt @ZacGermon #DIPG 💪 @RUNDIPG
Congrats, Sam and team! A super interesting review. Thank you for the opportunity to contribute.
Our new review on #hypoxia and #DNAmethylation in #AML is online today. We explored complex and bi-directional interactions between hypoxia signalling and regulation of DNA methylation as well as implications for AML therapy.
clinicalepigeneticsjournal.b…
Congrats Evie and team! Great summary of this paper below.
Incredibly proud to share the latest work from #DunLab, published in #CancerResearch! We highlight the combination of ONC201 and paxalisib for the treatment of DMG, the preclinical data informing PNOC022. Follow this tweetorial for a summary: (1/10)
aacrjournals.org/cancerres/a…
Zac Germon retweeted
A new study shows that inhibiting the oxidase NOX2 suppresses a common subtype of #AcuteMyeloidLeukemia (AML) in mice by blocking ROS in cancer cells—hinting that targeting NOX2 may potentiate precision therapies for AML. @ZacGermon @MattDun17 scim.ag/26a
Zac Germon retweeted
Probably my favourite part of adding to the literature, students/stuff pinning their first author papers to our walls of honour!
#DunLab #CSRG
#DunLab paper alert:
Patients diagnosed with the most common driver mutation in acute myeloid leukemia (AML) – FLT3, are associated with poor-outcomes.
FLT3+ AML sees the overproduction of reactive oxygen species (ROS), a second messenger signaling (T1)
doi.org/10.1126/scisignal.ab…
Excited to see this paper published today in @scisignal. This work formed a large part of my PhD and is summarised below:
#DunLab paper alert:
Patients diagnosed with the most common driver mutation in acute myeloid leukemia (AML) – FLT3, are associated with poor-outcomes.
FLT3+ AML sees the overproduction of reactive oxygen species (ROS), a second messenger signaling (T1)
doi.org/10.1126/scisignal.ab…
Zac Germon retweeted
Access to new drugs in paediatric oncology: can we learn from the ongoing ONC201 saga? @TheLancetOncol #DunLab, #CSRG @UON_research @HMRIAustralia @RUNDIPG thelancet.com/journals/lanon…
A wonderful Ashley Dunn oration from Prof. Karen Vousden @LorneCancer @LabVousden. Exciting and motivating to hear her elegantly discuss (my fave molecules!) ROS and their importance in tumour development and progression.
Thanks for the support @PrecisionMedUON. Glad to be part of the team!
#MeetTheTeam: Introducing Dr Zac Germon who is a Postdoctoral Fellow in the Cancer Research Signalling Group focused on proteomic, genetic & epigenetic approaches to understand the surrounding microenvironment of #Leukaemia & #DIPG to develop novel treatment strategies @ZacGermon
Zac Germon retweeted
Gr8 recent achievements to celebrate @ #DunLab
@TabMclachlan targeting BCL6 in pediatric cancers - bit.ly/3V5xrka
@DilanaStaudt #pHASED real-time phosphoproteomics data to aid in cancer drug selection rdcu.be/c3Jc8
Mika Persson cover of @NeuroOnc
Congrats Team!
Zac Germon retweeted
Excited to see the latest #DunLab pub out 2day led by @DilanaStaudt Here we have optimized a new protocol, phospho-heavy-labeled-spiketide FAIMS stepped-CV DDA #pHASED to identify oncogenic cascades to aid in drug selection for cancer patients in real-time
rdcu.be/c1Veg
Happy to have my PhD awarded to round out a great day at the @PrecisionMedUON symposium. Go team! A sincere thankyou to my mentors and supervisors @MattDun17 @DeVerrills @Dr_Heather_Lee @geoffdeiuliis and everyone along the way who made it possible.
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Such a great few days @NDLR_conference, so grateful to have been given the opportunity to present my work and to hear about some of the amazing work going on in the field. Exciting times!
My newest fave #DunLab / #CSRG tradition is congratulating my just submitted PhD student @ZacGermon on winning the @NDLR_conference New Investigator award for his pioneering work showing oxidative stress promotes altered epigenetic profiles in #AML
Super proud Z, congratulations!
