@_blake_smith

MD-PhD student @Harvard @MIT | interested in all things immuno, chem bio, viruses, IM, heme/onc, art hist | @Yale '16, NY native | @runthelistpod

 Boston, MA
Joined September 2019
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180Media
It’s hard not to get addicted to this. From side conversations with @MEBirnbaum to an incredible result for patients. So proud of the Kelonia team for all the hard work it took to make this real.
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1. ENTER #mRNAvaccines for #pancreaticcancer! Long-term #PDAC survivor story PART3. "Do #PDACs REALLY have vaccine neoantigens (NAs)"? (aren’t they lowly mutated?) If each patient = own NAs, how do you vaccinate? Maybe mRNA? But how? @Nature nature.com/articles/s41586-0… 👇🏽 [1/32]

Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer

Nature - A phase I clinical trial of an adjuvant personalized mRNA neoantigen vaccine, autogene cevumeran, in patients with pancreatic ductal carcinoma demonstrates that the vaccine can...

nature.com
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Thrombophilia & Anticoagulation (Handout from Run The List podcast @runthelistpod) #BJHM #MedEd #FOAMed #Thrombophilia #MedTwitter #Medstudenttwitter
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Very excited to share a big part of my PhD work out today @CellCellPress!! bit.ly/3tFw6pw We found that thymic epithelial cells use lineage-defining transcription factors to disguise themselves as extra-thymic cell types and identify/eliminate autoreactive T cells. 1/9

Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive...

Medullary thymic epithelial cells repurpose the lineage-defining transcription factors of diverse extra-thymic cell types to create cellular mimics of the peripheral self within the thymus, allowing...

cell.com
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Episode 74: Hypoxemic Respiratory Failure/ARDS topic cards are now out! anyone need to brush up on V/Q mismatch? 📝Download them free here: runthelistpodcast.com/pulmon… RTL episodes 👇 🍎apple.co/2XhpRIU 🔊spoti.fi/3caXvV3 #FOAMed #MedEd @MHMedical
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Episode 71: Approach to Shock topic cards are now out! we have *FIVE* topic cards for you today 📝Download them free here: runthelistpodcast.com/pulmon… RTL episodes 👇 🍎apple.co/2XhpRIU 🔊spoti.fi/3caXvV3 #FOAMed #MedEd @MHMedical
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Ep. 77: Med Ed for Residents, Fellows, and Faculty (Part 2) is now out! Host @_blake_smith talks w/ RTL co-founder Dr. Navin Kumar @NavinKumarMD in a 2nd episode about medical education, w/ a focus on later trainees/faculty 👇 🍎apple.co/2XhpRIU 🔊spoti.fi/3caXvV3
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Episode 70: COPD topic card is now out! + a bonus PFT topic card 🙌 📝Download them free here: runthelistpodcast.com/pulmon… RTL episodes 👇 🍎apple.co/2XhpRIU 🔊spoti.fi/3caXvV3 #FOAMed #MedEd @MHMedical
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Episode 69: Asthma & Social Determinants of Health topic card is now out! 📝Download it free here: runthelistpodcast.com/pulmon… RTL episodes 👇 🍎apple.co/2XhpRIU 🔊spoti.fi/3caXvV3 #FOAMed #MedEd @MHMedical
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The Birnbaum Lab has designed a new tool that screens huge libraries of antigens and immune cells at the same time. The tool could help make sense of complex immune recognition, and speed the development of more effective vaccines and immunotherapies. news.mit.edu/2022/immune-cel…

New tool reveals how immune cells find their targets

MIT biological engineers have devised a new experimental tool that allows them to precisely pick out interactions between a particular B or T cell and its target antigen.

news.mit.edu
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RAPTR is a viral pseudotyping and surface display-based library-on-library method to decode immune receptor and antigen identities. @MEBirnbaum @ItsVirusTime nature.com/articles/s41592-0…
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Episode 68: Approach to Dyspnea topic card is now out! 📝Download it free here: runthelistpodcast.com/pulmon… RTL episodes 👇 🍎apple.co/2XhpRIU 🔊spoti.fi/3caXvV3 #FOAMed #MedEd
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Happy to share our latest paper by @facts___matter on human T cell epigenome mapping. ATAC and RNA defined human T cell subsets identify functional enhancers, fate transitions, and transcriptional and epigenetic coordination of disease relevant T cells cell.com/immunity/fulltext/S…

Human epigenetic and transcriptional T cell differentiation atlas for identifying functional...

Giles et al. generated an epigenomic T cell differentiation atlas from healthy human donor (HD) blood. This atlas was used to (1) identify transcriptional and epigenetic modules in human CD8 T cell...

cell.com
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Episode 66: HIV topic card is now out! 📝Download it free here: runthelistpodcast.com/infect…… RTL episodes 👇 🍎apple.co/2XhpRIU 🔊spoti.fi/3caXvV3 @NeeralLShah & @MHMedical #FOAMed #MedEd
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Ep. 72: Pressors is now out! Host Dr. Navin Kumar @NavinKumarMD continues his discussion with repeat guest, ICU intensivist Dr. Virginia Brady, about pressor choice, diagnostic timeouts, and good ol' adrenergic physiology 🍎apple.co/2XhpRIU 🔊spoti.fi/3caXvV3
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Ep. 71: Approach to Shock is now out! Host Dr. Navin Kumar @NavinKumarMD chats with ICU intensivist Dr. Virginia Brady about how to quickly categorize shock in a patient p/w fever, tachycardia, and hypotension 🍎apple.co/2XhpRIU 🔊spoti.fi/3caXvV3
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Blake Smith retweeted
James Diao@JamesADiao25 Jan 2022
1/ Can a simple thumb trick save thousands from sudden cardiac death? Now out in #AmJCardiology, @arjunmanrai, @GloriaJWu, and I investigate the questionable clinical utility of a newly proposed “digital”😉 biomarker. ajconline.org/retrieve/pii/S…
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Ep. 63 Approach to Pneumonia topic card is now out! 📝Download it free here: runthelistpodcast.com/infect… RTL episodes 👇 🍎apple.co/2XhpRIU 🔊spoti.fi/3caXvV3 @NeeralLShah & @MHMedical #FOAMed #MedEd
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Ep. 70: COPD is out! Our 🫁 series continues as host Dr. Walker Redd @WalkerReddMD chats with pulm/CCM clinician-educator Dr. Katherine Walker about her approach to COPD in both inpatient & outpatient settings 🍎apple.co/2XhpRIU 🎶spoti.fi/3caXvV3
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Over the last two months I've read dozens of studies about gas stoves and indoor air quality. I also installed monitors in our home and ran my own tests. Here's a thread on what I learned 🧵 #energytwitter
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