@abin_abe

Prenatal health + Artificial intelligence Aspirining physician-scientist Neonatology Fellow @ChildrensPhila. @VanderbiltMSTP || @UMich @UMBE

 Philadelphia, PA
Joined May 2013
  • Tweets242
  • Following855
  • Followers332
5Media
The M1 class gathered for “Dosas and Mimosas” to celebrate class member Anvith’s cat Dosa’s second birthday!
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I am excited to share this preprint of a project working with the incredible @Lab_LaBella @RokasLab and @capra_lab. See the the link below for a short twitter thread! xitter.cf/Lab_LaBella/status/152…
The Lab LaBella@Lab_LaBella12 May 2022
Preprint Alert! We @abin_abe @Lab_LaBella @RokasLab @capra_lab asked which evolutionary forces have influenced genomic regions associated w/ human traits? We analyzed >900 GWASs to quantify enrichment for 14 evolutionary measures Paper: tinyurl.com/9ba8ceae Img: our approach
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Preprint Alert! We @abin_abe @Lab_LaBella @RokasLab @capra_lab asked which evolutionary forces have influenced genomic regions associated w/ human traits? We analyzed >900 GWASs to quantify enrichment for 14 evolutionary measures Paper: tinyurl.com/9ba8ceae Img: our approach
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Interesting read 👇👇 biorxiv.org/content/10.1101/…

The carbon footprint of bioinformatics

Bioinformatic research relies on large-scale computational infrastructures which have a non-zero carbon footprint. So far, no study has quantified the environmental costs of bioinformatic tools and...

biorxiv.org
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So excited to get this published. Using AI to estimate gestational age from placental h&e. nature.com/articles/s41374-0…
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Check out @CosminABejan preprint on DrugWAS! Looking forward to reading it! medrxiv.org/content/10.1101/…

DrugWAS: Leveraging drug-wide association studies to facilitate drug repurposing for COVID-19

Importance There is an unprecedented need to rapidly identify safe and effective treatments for the novel coronavirus disease 2019 (COVID-19). Objective To systematically investigate if any of the...

medrxiv.org
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Neat preprint from @VUMCResearch - looking in the #EHR, researchers did a drug-wide association study across all #COVID patients to see which drugs associated with lower morbidity and mortality. They saw 15 that could be further evaluated as treatments: medrxiv.org/content/10.1101/…

DrugWAS: Leveraging drug-wide association studies to facilitate drug repurposing for COVID-19

Importance There is an unprecedented need to rapidly identify safe and effective treatments for the novel coronavirus disease 2019 (COVID-19). Objective To systematically investigate if any of the...

medrxiv.org
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Abin Abraham retweeted
Dmitry Rychkov@rogdin25 Jan 2021
Our paper on precison sub-phenotyping of stable kidney transplants is finally out at JAMA Network Open! Congrats and huge thanks to @minnie_sarwal @msirota84 and Swastika Sur! jamanetwork.com/journals/jam…

Molecular Diversity of Clinically Stable Human Kidney Allografts

This prognostic study uses microarray gene expression data from the National Center for Biotechnology Information Gene Expression Omnibus to assess whether immunologic heterogeneity can be identified...

jamanetwork.com
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International GWAS of suicide attempt (SA) finds strong SA locus, genetic independence of SA and psych dx and shared genetic overlap with risk factors (smoking, SES, sleep, risk taking) not mediated by psych dx. Incredible effort led by @NiamhAMullins and @Jay_J_Kang. Details 👇
Niamh Mullins@NiamhAMullins4 Dec 2020
Very excited to share the first preprint from the International Suicide Genetics Consortium: “Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors” (N ~30,000 cases) medrxiv.org/content/10.1101/… @Jay_J_Kang @DMRuderfer
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Abin Abraham retweeted
Marina Sirota@msirota8424 Oct 2020
So proud of my team for publishing our work on drug repurposing and validation of therapeutics for COVID-19! biorxiv.org/content/10.1101/… - led by @BrianLLe89 @gaiaandreoletti @tomiko22 in collaboration with many others! @iditkosti @DanBunis @TheOttLab @UCSF_BCHSI @IcahnMountSinai

Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19

The novel SARS-CoV-2 virus emerged in December 2019 and has few effective treatments. We applied a computational drug repositioning pipeline to SARS-CoV-2 differential gene expression signatures...

biorxiv.org
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Abin Abraham retweeted
Sarah Fong@slifong5 Aug 2020
I’m excited to share our preprint on the evolutionary architectures of human enhancer sequences. These evolutionary architectures can distinguish cool genomic, functional, and TE features in human enhancers. More work to come with @capra_lab! biorxiv.org/content/10.1101/…

Modeling the evolutionary architectures of human enhancer sequences reveals distinct origins,...

Motivation Despite the importance of gene regulatory enhancers in human biology and evolution, we lack a comprehensive evolutionary model of enhancer sequence architecture and function. This substa...

biorxiv.org
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Abin Abraham retweeted
Capra Lab@capra_lab28 Jul 2020
So pleased to share our latest in @NatureEcoEvo showing that Neanderthal introgression reintroduced thousands of lost ancestral variants with gene regulatory activity and that these reintroduced alleles are more tolerated than Neanderthal-derived alleles: rdcu.be/b5R5u
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Abin Abraham retweeted
Capra Lab@capra_lab24 Jul 2020
Check our recent paper demonstrating a mosaic of selective pressures on loci associated with preterm birth. Great work led by @abin_abe in my group and @AbbeAtSea in the @RokasLab with help from @zg_uc and others. rdcu.be/b5O4M
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Excited to share my preprint on predicting preterm birth form electronic health records! Thank you to my collaborators and mentor @capra_lab!
Capra Lab@capra_lab17 Jul 2020
Excited to share our preprint on using machine learning to predict preterm birth risk from ~40,000 electronic health records from Vanderbilt and UCSF. Great collaboration lead by @abin_abe with: @msirota84, @RokasLab, @CosminABejan, @Velez_Edwards, others. medrxiv.org/content/10.1101/…

Dense phenotyping from electronic health records enables machine-learning-based prediction of...

Identifying pregnancies at risk for preterm birth, one of the leading causes of worldwide infant mortality, has the potential to improve prenatal care. However, we lack broadly applicable methods to...

medrxiv.org
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Abin Abraham retweeted
Capra Lab@capra_lab17 Jul 2020
Excited to share our preprint on using machine learning to predict preterm birth risk from ~40,000 electronic health records from Vanderbilt and UCSF. Great collaboration lead by @abin_abe with: @msirota84, @RokasLab, @CosminABejan, @Velez_Edwards, others. medrxiv.org/content/10.1101/…

Dense phenotyping from electronic health records enables machine-learning-based prediction of...

Identifying pregnancies at risk for preterm birth, one of the leading causes of worldwide infant mortality, has the potential to improve prenatal care. However, we lack broadly applicable methods to...

medrxiv.org
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Congratulations to Dr. Michael Raddatz for successfully completing his Dissertation Defense today!
Demetra Hufnagel, MD@DemetraHufnagel13 May 2020
So proud of and excited for @MichaelR21 who is now Dr. Raddatz! Thank you to everyone who has made this celebration so special even from afar!!
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Today’s episode kicks off part 1 of our five part feature on @VanderbiltU! This first episode hosts Dr. Chris Williams (@williams_lab), professor of @VUmedicine and director of @VanderbiltMSTP. podcasts.apple.com/us/podcas… #behindthemicroscope #sciencebehindthescenes #doubledocs
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Abin Abraham retweeted
Patrick Phillips@granex29 Mar 2020
New preprint: Sexually Antagonistic Selection on Genetic Variation is Rare in Humans. Giant analysis led by @katjakasimatis in collaboration with Abin Abraham in Tony Capra’s lab. With @pastramimachine and @petrelharp. biorxiv.org/content/10.1101/…

Sexually Antagonistic Selection on Genetic Variation is Rare in Humans

Sex and sexual differentiation are ubiquitous across the tree of life. Because females and males often have substantially different functional requirements, we would expect selection to differ...

biorxiv.org
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cannot emphasize this enough! A great role model for us as future physician-scientists!
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Three of our G3 @VanderbiltMSTP students contributed to this work @MichaelR21 @BReinfeld @madden_mz!!
W. David Merryman@merrymanlab25 Jan 2020
New preprint from @MichaelR21 @meena_s_madhur @JeffRathmell @KimrynRathmell @vumcvalve @merrymanlab @VanderbiltMSTP @VandyBME Macrophages Promote Aortic Valve Cell Calcification Through STAT3 Splicing biorxiv.org/content/10.1101/…

Macrophages Promote Aortic Valve Cell Calcification Through STAT3 Splicing

Objective Macrophages have been described in calcific aortic valve disease, but it is unclear if they promote or counteract calcification. We aimed to determine how macrophages are involved in...

biorxiv.org
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