@akellerlab

Neurovascular biology lab https://xitter.cf/t.co/gJnbIlQZyC @UZH_Science, @Unispital_USZ led by @annikakeller_ #pericyte #bloodbrainbarrier #glia #calcification

 Zürich, Switzerland
akellerlab.ch/
Joined January 2021
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Models of human #pericytes at the Anatomy Institut in Bern built in 1914 by Zimmermann. Magnification 6000x 🤩.
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Happy to share recent work from our lab published in the Life Science Alliance - Targeting TREM2 signaling shows limited impact on cerebrovascular calcification | Life Science Alliance (life-science-alliance.org).

Life Science Alliance

life-science-alliance.org
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Administration of TREM2 activating antibody shows limited impact on cerebrovascular calcification @akellerlab @UZH_en life-science-alliance.org/co…
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Very happy to see our work finally in print 🥳😊😀Learn more how aging and senescent cells impairs nerve functions in the heart science.org/doi/full/10.1126… Thanks to the entire teams particularly @JulianW27954793 and our great collaborators @dzhk_germany @CPI_ExStra
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Unique #postdoc opportunity! azrielifoundation.org/the-az… We are looking for a suitable candidate to follow up on #microglia migration (doi.org/10.1093/cercor/bhaa2…) and interaction with the surrounding white matter micro-environment. Please RT.
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In our recent study doi.org/10.1111/bpa.13189, in addition to vascular changes in brains of Xpr1 +/- mice, we also observed “dark microglia” and microglia with fibrillar inclusions. What are these microglia doing – yet to figure out...#microglia #pathology
MG with fibrillar inclusions

ALT MG with fibrillar inclusions

Dark MG

ALT Dark MG

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Recent work from our lab spearheaded by talented @UpasanaMaheshw3 XPR1 is the only known mammalian phosphate exporter and its LOF in humans leads to a neurological disease. doi.org/10.1111/bpa.13189
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Exciting🥳 Our new study in Cell shows that our skull is a gateway for diagnosing & potentially treating brain diseases such as Alzheimer's & stroke. Imagine a future where a portable sensor on the skull can monitor brain health! @CellCellPress cell.com/cell/fulltext/S0092… 🧵👇🏼with🔈
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Great neurovascular session at the #BonnBrain meeting! Glad to share the stage with fantastic researchers @PBNeuroVascLab, @annikakeller_, & @caromenard666 😍 #vesselsmatter
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I’ve learned from a decade on this app to not accept the superficial way things are presented here, especially when someone’s words are being used against them. And so I watched the whole session for context. And I’m glad I did. Because in context it’s way worse.
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I had a wonderful time last night with these two brilliant vascular scientists @annikakeller_ & @JoannaKalucka! Hope that touching Greyfriars Bobby’s nose will bring you even more success, grant money and papers in the future! 😁 Let’s catch up soon! – at Edinburgh, Scotland
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Our lab (Viviana Gradinaru Lab) at Caltech (glab.caltech.edu and clover.caltech.edu) has multiple open positions, join us at the sunny south California! #apply through the 2 postings below: lnkd.in/g7QrKU3r lnkd.in/gShEdPsP (updated from prior posting)
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That’s a wrap on #CVB2023! Great meeting, learned a lot about the more clinical side of cerebral vascular biology, heard a little bit of choroid plexus research (not enough!!) & got to know Sweden a bit. – at Sigtuna, Sverige
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#CVB2023 @UpasanaMaheshw3 poster 171 accepted for publication @brainpathol Happy days 🎈🍾
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#CVB2023- BBB/BBQ evening in Uppsala. Conference at its best 😍 with @akellerlab @MontagneLab @betsholtz @MartinMlauritz @AyalBen @kucharz_neuro Benoit Vanhollebeke, Lara Organshola, Stefan Liebner
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#CVB2023 Uppsala with Rich Daneman 🤩
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The happiness when your reviewer’s comment reads “Congratulations for this really nice piece of work” 🥲😬 Manuscript accepted :) :) @akellerlab
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🇨🇭 Did you know that the term "#endothelium" was introduced by a #Swiss anatomist Wilhelm His Sr. (Basel) in 1865? The term "#pericyte" was first time used by a #Swiss anatomist Karl Wilhelm Zimmermann (Zürich) in 1923 ? 🇨🇭
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I have to correct myself- Zimmermann worked in Bern, not in Zürich. 🤦‍♀️Eberth, who's was most likely the first to draw pericytes (he called them advential cells) was working in Zürich! Now we have all Swiss cities covered 😉
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Microrobots in the brain Vasculature!   We use microrobots and control them wirelessly in the brain vessels (even against the flow). We are just at the beginning of this exciting field. What kind of application do you imagine? biorxiv.org/content/10.1101/… #innovation #medtech
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