Alan Master (@alanmaster_) header
Alan Master (@alanmaster_) profile picture

💎Blockchain Enthusiast

Liverpool, England
Joined March 2016
Photo by Alan Master (@alanmaster_)Photo by Alan Master (@alanmaster_)Photo by Alan Master (@alanmaster_)Photo by Alan Master (@alanmaster_)Photo by Alan Master (@alanmaster_)Photo by Alan Master (@alanmaster_)Photo by Alan Master (@alanmaster_)Photo by Alan Master (@alanmaster_)Photo by Alan Master (@alanmaster_)
Alan Master retweeted
Getting a model to propose a therapy is the easy part. It'll do it in nine seconds and sound completely certain. A good chunk of it is wrong. So mediclaude.org/ is built around the second model, not the first. Evidence first. There's a knowledge graph called the Monarch Initiative, the one clinical geneticists actually use. Curated links between a disease, its causal genes, the phenotype spectrum, which of those genes turn up in other diseases. Public API, no key, you can hit it yourself right now. Engine pulls one disease off the queue and grabs all of it. Model 1 reads that and enters 6-8 candidate therapies. Deliberately mixed. Some boring repurposing plays, some long shots it probably can't defend. Then model 2 gets the exact same evidence and one instruction: kill these. Four rounds. Round 1 is basic. Does the drug exist. Is it even aimed at this disease. Round 2 it defends the whole causal chain. Variant, protein, pathway, the actual symptoms sitting in the data. Round 3 can you make it, can you get it to the tissue, and has somebody already tried this and failed. Round 4 name the cheapest experiment that would prove you wrong. no experiment, no survival. Kills are permanent. No rewrite, no appeal, no second draft. Survivors get published. So does everything that died, with the exact reason and the round that killed it. The kill log is honestly the more interesting half. No human touches any of it. it just runs. nitter.gq/DarioAmodei/status/208…
Replying to @DarioAmodei
2/2 Second, on the messaging around AI.  I do not agree that my messaging has been disproportionately negative.  In fact it has been about equally balanced between risks and benefits: I’ve written one major essay about each, and even in interviews where I discuss the risks, I make sure to frequently mention the incredible benefits as well as proposing possible solutions to the risks (short clips from my interviews that end up on social media tend to be disproportionately negative, as that gets clicks).  In fact, I wrote Machines of Loving Grace because I didn’t feel the AI industry was painting an inspiring enough picture of how the technology could radically transform the world for the better.  The bulk of the essay is devoted to refuting skepticism of AI’s potential in health and biology, and showing why I think it will actually be possible to cure most human disease in ~5-10 years, as crazy as it may sound to ordinary people and frankly to biologists as well (I used to be one!).  And, if you read my most recent essay (Policy on the AI Exponential), I discuss concrete proposals for how to streamline the FDA process to make sure the deluge of AI-accelerated drugs isn’t slowed down by the regulatory process.  I feel the urgency here: I lost my father to Hepatitis C only a few years before the development of direct-acting antivirals (sofosbuvir), which cure 95% of patients and probably would have cured him. I do agree that the public has a negative view of AI (and that this is a big problem), but I don’t think it is primarily caused by me or any other AI leader warning about AI’s risks.  I think it is fundamentally a crisis of trust.  I think that ordinary people don’t trust companies, governments, or the tech industry and always suspect that we are cooking up some new way to screw them over.  The causes of this go back decades and AI is just the latest iteration of it.  I don’t think that a glitzy marketing campaign with a positive spin (which some have advocated that Anthropic do) is the way to win back that trust — at this point, saying that AI will cure cancer is more a cliche than it is inspiring, and most people think it is deceptive.  The thing that will work is *actually curing cancer*.  I think by far the most accurate criticism of AI companies including Anthropic is that we haven’t yet delivered on our big promises to benefit the world.  That is totally on us, and I think it’s the criticism you should be making, instead of all this stuff about messaging and marketing. We are however doing our best to fix this: Anthropic is ramping up its efforts very quickly in biology and medicine, and we hope to have incredible results in the coming years and some early glimmers in the coming months.  When we’ve actually accomplished something real, the whole world will hear about it, as loudly as possible, you have my word on that.  But until then I don’t want to make empty promises, and in the meantime I feel compelled to speak honestly about the very real risks of AI and how to address them.  Honesty is the right thing on the merits, and in terms of public credibility and trust it is no worse than, and may in fact be better than, an approach that ignores or distracts from risks which people instinctively understand are real.
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Alan Master retweeted
Accelerate mediclaude.org
Anthropic CEO Dario Amodei believes AI can help “cure most human disease” in 5-10 years
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Alan Master retweeted
Today the challenger gave up before it could be killed: · "I concede this candidate — withdraw rather than defend" · "Weakest link: The whole thesis" · "I have no replacement agent I can name and defend" · "there is no real defensible therapeutic entity" Withdrawing is allowed. We publish the withdrawal. mediclaude.org/
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Alan Master retweeted
Replying to @SaturnCoinBNB
For most along the path, totality lasts less than two minutes. Near the centerline over Greenland or the North Atlantic, it reaches close to two and a half minutes.
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Alan Master retweeted
Replying to @NASA
How long will the eclipse last at its peak?
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Alan Master retweeted
gritcult talks about this...
Weird economics up on the agent-only runescape server - Low cost of labor makes most commodities abundant - Currency inflation means trading goods for goods, nobody really wants cash - Huge swarm contention as certain resources with limited respawn rate become valuable
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$PALU THE OFFICIAL BINANCE MASCOT Now live on @flapdotsh Hold $PALU to earn $BNB 🥳 0x769d821138fe8030692af39855e4de7a04657777
Replying to @binancezh
🙋空白模版奉上,等待大家的精彩创意: ps:曾几何时帕鲁也有机会成为玩偶,但是老板说帕鲁形象脑袋太光了像emoji🥹
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Replying to @Binance_intern
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Alan Master retweeted
Here’s proof that our lore is 100% real. Give this official Robinhood link to any AI and ask it to decode the contents & you’ll uncover the same hidden cat every time. cdn.robinhood.com/app_assets… It has been preserved in Robinhood’s code since 2022, and the evidence is open for anyone to verify. Now let the cat out of the box.
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Alan Master retweeted
Your portfolio deserves some weight. $GLDx is live on $DIVVY for holders to choose as a reward. 8qsXKEF12KwAnFU5YdRuzopfKj1HJ73D8QK8hYtSPabh mydivvy.app/
Gold is live on $DIVVY! $GLDx is earned and distributed. Bringing a new class of RWAs to the Divvy Ecosystem. A fee on every swap buys tokenized stocks & RWAs then divvies them up across all holders. 8qsXKEF12KwAnFU5YdRuzopfKj1HJ73D8QK8hYtSPabh mydivvy.app/
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Bullish on PreStocks builders. 🐂🔥 Let the new narrative be onchain pre-IPO stocks.
All thanks to and powered by @Meteora and @PreStocks on @Solana. Allowing us to $DIVVY up a basket of tokenized RWAs to our holders. We keep building, keep innovating, and keep accelerating the growth of tokenized equities and Pre-IPO shares on Solana. 8qsXKEF12KwAnFU5YdRuzopfKj1HJ73D8QK8hYtSPabh mydivvy.app/
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Alan Master retweeted
Hertz Global Holdings Inc OFFICIAL X ✅ WallStreetBets might have found its next movement. After turning Wendy's into one of the most iconic meme stocks of all time, the community is now rallying behind Hertz ($HTZ). "Let's save Hertz" posts are starting to flood the subreddit, with traders piling into calls and shouting "hold the line" as speculation around a turnaround grows. Over $6k USD bought in $HTZ NASDAQ STOCK to help the short squeeze to the moon. Market is ready as ever. Updates: - Over $6k USD bought in $HTZ NASDAQ STOCK to help the short squeeze to the moon. - Invested in IRL Stock options of $HTZ - Website Created - Token Verifications submitted - WallStreetBets article submitted - New ATH of 1.4M Just the beginning. A lot more in store, this is just the beginning. Genuine question, who wants a @Hertz Rental this weekend? All expenses covered. reddit.com/r/wallstreetbets/… EnA53NmMzfsAs7p44dATdvT55HHUACxpEbC9AKY3pump
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Alan Master retweeted
Replying to @ethicslaunch
🚢🚢🚢
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New launchpad is cooking. Launch token with RWA backed tokens as <redacted> Tick tock tick tock ⏳
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Alan Master retweeted
Jobs not finished. Will be buying more stock options shortly. Let me cook. We're just getting started.
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Alan Master retweeted
Will create official X page to document the latest r/Wallstreetbets series. In the Meantime - Invested in IRL Stock options of $HTZ - Website Created - Token Verifications submitted - WallStreetBets article submitted - New ATH of 250k Just the beginning. A lot more in store, this is just the beginning.
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Alan Master retweeted
OG - Hertz Global Holdings Inc WallStreetBets might have found its next movement. After turning Wendy's into one of the most iconic meme stocks of all time, the community is now rallying behind Hertz ($HTZ). "Let's save Hertz" posts are starting to flood the subreddit, with traders piling into calls and shouting "hold the line" as speculation around a turnaround grows. Its up 38% just today... reddit.com/r/wallstreetbets/… EnA53NmMzfsAs7p44dATdvT55HHUACxpEbC9AKY3pump
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Alan Master retweeted
Bought 123+ shares of $HTZ on the Nasdaq so far & we’re already in profit. Plenty more buys coming. Rewards will be redeemed by the community by doing so. We’re just getting started.
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Alan Master retweeted
I roundtripped the old $unicorn just cause I had the vision of it going to 8 figure valuations, now you're getting the chance at it again but properly this time. With Uniswap launching their actual launchpad pools.trade I think this makes way more sense than the old Uniswap Auctions. If you don't know what the vision for $unicorn is, consider the following: - Mascot of Uniswap (See the image below) - Mythical creature, which has the meaning that there's more possible than you think. - A startup valuated at 1B or higher, makes sense on the stock chain. See: robinhood.com/us/en/learn/ar…
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