Alex Böcker retweeted
My lab is starting at UW-Madison! This is a unique opportunity to contribute to impactful computational neuropathology research in a collaborative environment. Join the Nirschl Lab and help drive discoveries that improve our understanding of neurodegenerative disorders!🧠
Alex Böcker retweeted
Excited to share my postdoc work, "Autophagic stress activates distinct compensatory secretory pathways in neurons"
Now on BioRxiv! biorxiv.org/content/10.1101/…
Alex Böcker retweeted
Congratulations to Erika Holzbaur for securing a $1,000,000 donation to establish a Huntington’s Disease Research Fund. The donation will be used to support Huntington’s research by three postdoctoral fellows for three years in key University laboratories.
Alex Böcker retweeted
So proud of this beautiful new work from Dan Dou, and so grateful to Virginia Lee for inspiring this study!
Dou, Aiken & @ErikaHolzbaur @PennMedicine show that #Parkinsons disease-associated hyperactive LRRK2 decreases the trafficking of synaptic vesicle proteins within neurons by disrupting the regulation of the synaptic vesicle precursor protein RAB3A. hubs.la/Q02qgtts0
Alex Böcker retweeted
Dou, Aiken & @ErikaHolzbaur @PennMedicine show that #Parkinsons disease-associated hyperactive LRRK2 decreases the trafficking of synaptic vesicle proteins within neurons by disrupting the regulation of the synaptic vesicle precursor protein RAB3A. hubs.la/Q02qgtts0
📢 Fully funded PhD position available in my lab in Goettingen, Germany
If you are interested in cell biology and the pathophysiology of neurodegenerative diseases, we'd love to hear from you!
📅 Application Deadline: Feb 9th 2024
For more details visit
boecker-lab.uni-goettingen.d…
Alex Böcker retweeted
Excited that our paper reporting discovery of TMEM55B, a new downstream lysosomal component of the LRRK2 #Parkinsons pathway, has been published. Congrats @Prosen21, @MattTaylor_69, Yuko Lam, & our fantastic @ASAP_Research collaborators @pfeffersuzanne lab ppu.mrc.ac.uk/news/parkinson…
Alex Böcker retweeted
My last paper from grad school is in press! Please check it out--thanks to good suggestions from reviewers and a lot more work, it has a significantly more detail than the BioRxiv version @ErikaHolzbaur @JCellBiol doi.org/10.1083/jcb.20230108…
Alex Böcker retweeted
What regulates the transport of autophagosomes along the axon? @sydneycason & @ErikaHolzbaur show that mature axonal autophagosomes are transported by the #microtubule motor #dynein, activated by JIP3/4, & regulated by ARF6 & RAB10 bit.ly/3MrP5Nw
#Neuroscience #autophagy
Alex Böcker retweeted
RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors biorxiv.org/content/10.1101/…
Alex Böcker retweeted
📣Take away: OPTN does it differently!
🚨Thrilled to share my latest #notacover piece prepared for @ThanhNguyen_TNN @LazarouLab @martens_sascha @mito911_ on #unconventional #OPTN-mediated #PINK1/#Parkin #mitophagy!
sciencedirect.com/science/ar…
Alex Böcker retweeted
Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes dlvr.it/SnPb92
Very happy to share our latest work on LRRK2 (and my first paper as co-last author). We find that LRRK2 mutations disrupt a regulatory balance between LRRK2, PPM1H, and ARF6, causing impairment of axonal autophagosome transport. @DanDou52257793 @ErikaHolzbaur @yourUMG
Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes dlvr.it/SnPb92
Alex Böcker retweeted
A threat to all scientists in Germany, particularly to postdocs: On 17 March the German Ministry of Science released a paper on the planned amendment of the German Act on Temporary Scientific Contracts. Contracts for postdocs shall be limited to 3 years - then you are out!.....
Happy to share this review on LRRK2 and intracellular organelle dynamics @JMolBiol. Enjoy! authors.elsevier.com/a/1gbUA…
Alex Böcker retweeted
Excited to see this online!
The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy.
doi.org/10.1016/j.celrep.202…
Alex Böcker retweeted
Our first preprint is out from the Stavoe Lab! with @heathertsong and @ErikaHolzbaur
Aging Differentially Affects Axonal Autophagosome Formation and Maturation biorxiv.org/content/10.1101/…
Alex Böcker retweeted
Happy to share our paper @SciReports. We describe and characterise a novel iPSC microglia-motor neuron co-culture, which can be used for #MND #ALS research. Special thanks to @Crambberriee @WadeMartinsLab for a great collaboration. @NDCNOxford @KavliOxford nature.com/articles/s41598-0…
Alex Böcker retweeted
Beyond excited to share my thesis work characterizing the role of p62 phase condensates in lysophagy! biorxiv.org/content/10.1101/…
Alex Böcker retweeted
I'm thrilled to share new work from Elizabeth Gallagher providing new insights into the clearance of damaged lysosomes by lysophagy:biorxiv.org/content/10.1101/…. Lysosomal health is critical to neuronal health, making this work highly relevant to Parkinson's disease and ALS.