The Children's Brain Tumour Drug Delivery Consortium takes on the challenge of drug delivery over the blood-brain barrier, to children with brain tumours
Joined March 2017
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In response to our community highlighting 'difficulty navigating the regulatory landscape' as a major challenge to clinical translation, we have produced a roadmap document that we hope will help: cbtddc.org/documents/roadmap… @CRUKCamPaeds @EdinCRC @CwC_UK_Research @rumanrahman01
Check out our review paper 'Childhood Brain Tumors: A Review of Strategies to Translate CNS Drug Delivery to Clinical Trials. Thanks to all contributors 👏👏@rumanrahman01 @WillGBSingleton @johnboockvar @LukasFaltings @MOliveira1977 @CwC_UK_Research
mdpi.com/2072-6694/15/3/857
In this newsletter: Precision Medicine @NICONeuroCorp, treating brain tumours with poliovirus @DukeU, Dragons' Den & future BNOS conferences @BNOSofficial, Cancer Trial Finder @ECMC_UK @CRUKresearch, job opportunity with @DrSadhanaJ, and more - bit.ly/CBTDDCJan2023newslett…
Great to hear 👏👏
World-first: Sunnybrook and @SickKidsNews are the first in the world to use MRI-guided focused ultrasound to deliver chemotherapy in Diffuse Intrinsic Pontine Glioma, an aggressive and terminal pediatric brain tumour.
Read more about the trial: bit.ly/3GxvszN
CBTDDC retweeted
News: #ClinicalTrial of Sonodynamic Therapy for #Glioblastoma Begins in Milan
The study, led by Francesco Prada, MD of the Carlo Besta Neurological Institute, will use @INSIGHTEC's #focusedultrasound device & is funded by the Focused Ultrasound Foundation. bit.ly/3XezwfS
CBTDDC retweeted
Excited to share that our #gbm trial is underway and 3 patients have been treated with our novel, non-invasive #SDT therapy! Thanks to our partners, we are changing the landscape of #braincancer treatment.
Learn more at prn.to/3tjAwBS
Last few days to add your voice to this ⬇️
What is cancer's toughest challenge?
We're leading a global conversation to identify a new set of #CancerGrandChallenges - and we want to hear from you.
Have your say and help shape our next round of #funding.
Submit your idea by 28 Nov: cancergrandchallenges.org/Ch…
#CancerResearch
Exciting early phase study using convection-enhanced delivery to get treatment to the site of glioblastomas within the brain ⬇️
We are pleased to announce the enrolment of the first patient into our Phase 1 study of #MTX110 in recurrent glioblastoma at the Preston Robert Tisch Brain Tumor Center at Duke University, USA.
For more information, please visit linkedin.com/feed/update/urn….
#MidatechPharma #MagicG1
.@Oncotelic has submitted a protocol to the FDA for a Phase 1 Trial for OT-101 (a transforming growth factor beta 2 inhibitor) as a treatment for paediatric patients with recurrent/relapsed DMG. The drug would be administered via the cerebral spinal fluid. oncotelic.irpass.com/Oncotel…
BNOS Neuro-Oncology Dragons' Den. More info here: bnos.org.uk/wp-content/uploa…
Investigator Webinar: Enhance your Chance of Success with NIHR HTA Funding
Thu, 17 November 2022, 16:00 – 17:00 GMT
eventbrite.co.uk/e/investiga… @NIHRresearch @NIHR_RDSEM
UCL Brain Cancer Seminar Series. On Weds 7th Dec, presentations include Nir Lipsman - Focused Ultrasound in Neuro-Oncology: Early Experience in Human Trials. Register here: eventbrite.co.uk/e/ucl-brain… @UCL_Ultrasound @UofTNeuroSurge @FUSFoundation @MayaThanou
A great opportunity to help shape the next round of funding for the Cancer Grand Challenges scheme. 'Whether you're a researcher, clinician, supporter, funder or person affected by cancer, you can have your say.' Deadline 28th November.
cancergrandchallenges.org/Ch…
This sounds like a great resource ⬇️
Do you spend a lot of time identifying suitable #clinicaltrials for patients?
Now open to all clinical staff in the UK, Experimental Cancer Trial Finder is a free new search tool to make it quicker & easier to match patients to early-phase cancer trials: bit.ly/3T4nkLF
Review on medical devices for delivering effective treatments for glioblastoma doi.org/10.3390/cancers14215…
@ImperialSom
CBTDDC retweeted
@GammaTile has announced the enrollment of the first patient into the GESTALT (GammaTile Enhanced Stupp ALTernative Trial) of GammaTile Surgically Targeted Radiation Therapy (STaRT) for patients with newly diagnosed glioblastomas.
Read more here: ow.ly/gLex50L72MQ
Great work by the Eden2020 team 👏👏
Published! Our work on the first neurosurgical platform to deliver an implantable steerable needle for a range of diagnostic and therapeutic applications @ImperialMechEng @BME_UMCG_RUG @polimi @RenishawMedical @TU_Muenchen @LaStatale @MyUniSR @XographHC 👇journals.plos.org/plosone/ar…
Because of slow & variable study set-up timelines, the number of participants recruited to industry clinical trials fell by 44% between 2017/18 & 2021/22. As a result, the number of industry clinical trials initiated in the UK per year has fallen by 41% between 2017 and 2021.
NEW: Our latest report reveals that UK industry clinical trials are facing collapse - impacting patients, the NHS, and UK life sciences. Urgent action is needed now to get back on track. abpi.org.uk/media/news/2022/…
Just a snapshot of the funding opportunities you can find on our website. Find these, and more, here - cbtddc.org/funding-opportuni… @CR_Horizons @BRUKresearch @Anticancerfund @AnticancerOrgUK @UKRI_News @NIHRresearch @BBSRC @CRUKresearch
Researchers tested a subcutaneously implanted catheter-pump system capable of repeated, chronic CED of topotecan into the brain in five patients with recurrent glioblastoma. @columbianeuro @MikeArgenziano @PCanoll @MateiBanu
DOI:doi.org/10.1016/S1470-2045(2…