@chr_mayer

Group Leader at MPI-BI, studying neuronal dev and differentiation. Also on Mastodon (@cmayer@fediscience.org ) where I value open, community-driven science.

 Munich, Germany
mayerlab.net
Joined September 2012
  • Tweets169
  • Following422
  • Followers948
7Media
Now out in #NatureNeuroscience: new paper from our lab — "Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice." Congrats to first authors Ann Bright, Yana Kotlyarenko, Florian Neuhaus! nature.com/articles/s41593-0…

Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice

Nature Neuroscience - Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral...

nature.com
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What a journey this paper has been 🎢 Excited to see some early data back from @chr_mayer lab @MPIforBI grow into such a beautiful piece of neurodevelopmental biology ⭐️ Huge kudos to @Alan_Zhou_95 and @Bocchi_Ric for the fantastic work! 🙌🏻
Riccardo Bocchi@Bocchi_Ric30 Jul 2025
🚨 First paper from the Bocchi lab out now in @NatureComms! We show that astrocytes in the cortex arise from not one, but two distinct progenitor lineages, each giving rise to specialized subtypes with distinct roles. Here the story📖 doi.org/10.1038/s41467-025-6… See 🧵below for more.

Dual lineage origins contribute to neocortical astrocyte diversity

Nature Communications - Astrocytes display diverse molecular and functional features in the brain, but the developmental origins of this heterogeneity are not well understood. Here, the authors...

nature.com
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Attended the Neurogenomics Conference @humantechnopole in Milan earlier this week. Great venue and an inspiring environment. Thanks to the organisers for putting together a strong and engaging meeting. #NeuroGen25
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Interested in single cell genomics but need help getting started? Check out the full agenda for our Single Cell Genomics Day on Friday 4/25. All talks will be live-streamed (no registration required) at satijalab.org/scgd25
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The Single-cell Analytics Innovation Lab @MSKCancerCenter is expanding and looking for Junior Research Technician! Join our team based in NYC to work on cutting-edge single-cell & spatial genomics methods in collaboration with leading research labs. sail.mskcc.org/
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🚨🎓 New application round: Join us in researching the multiple facets of biological intelligence and become a PhD student at our fully funded graduate school IMPRS-BI in the Munich area! 🔔 Application period: October 1 to November 10 🌐 Apply here: imprs-bi.mpg.de/
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Hiring alert 📢 my lab has TWO openings for a postdoc in computational biology! Please apply if you're interested to work with large in situ RNA-seq datasets and amazed by developing biological neural networks (mouse brains): ki.varbi.com/en/what:job/job… ki.varbi.com/en/what:job/job…

Postdoctoral Researcher in computational biology

Do you want to contribute to top quality medical research? The Ratz lab is working at the intersection of systems neuroscience, synthetic biology and spatial transcriptomics. Our goal is to reveal the

ki.varbi.com
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Christian Mayer (@[email protected]) retweeted
IMPRS-TP@ImprsTp27 Jun 2024
📅 Save-the-date! We are excited to welcome @chr_mayer to @mpi_psychiatry as our next MPLS speaker on 11. July (Thu). His talk will shed light on fundamental neuronal mechanisms 🧠 and the pathways 🧬 contributing to #neurodevelopmental disorders. This talk is open to everyone!
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My lab is looking for a research assistant to work on barcoded viral tracing in the developing mouse brain: ki.varbi.com/what:job/jobID:… Please apply if you’re interested to explore molecular mechanisms of neural circuit assembly in vivo!

Forskningsassistent i ”single-cell molecular connectomics”

Vill du bidra till medicinsk forskning av toppkvalitet? Forskargruppen under ledning av Michael Ratz vid institutionen för cell- och molekylärbiologi söker en forskningssistent. Labbet är beläget

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Our latest from @briscoejames lab: How temporal & spatial pattering cues are integrated in the vertebrate neural tube to organise cell type generation during development. biorxiv.org/content/10.1101/…
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Outstanding PhD work by our super-talented Lucia Del Valle, with the help of superb collaborators at @NeuroAlc @MPIforBI @LMU_Muenchen @CsicLifehub @CSIC @SENC_ science.org/doi/10.1126/scia…

Multiple parallel cell lineages in the developing mammalian cerebral cortex

Multiple radial glia cell classes establish parallel lineages in the developing cortex of mammals with the large and folded brain.

science.org
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Happy to see our new story published. 3 types of cortical Radial Glia Cells revealed: alpha, beta and gamma, with different amplificative behavior and involved in different cell lineages, that run together and in parallel in different germinal layers. Ferret is a superb model (1)
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Study "Multiple parallel cell lineages in the developing mammalian cerebral cortex" led by @LdelValleAnton and @BorrellLab is published. Congrats to our lab members @flo_neuhaus @edvoretskova @BabalKoray @ChaoFeng for their contribution! Link: science.org/doi/10.1126/scia… @MPIforBI
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Here is the correct link: science.org/doi/10.1126/scia…

Multiple parallel cell lineages in the developing mammalian cerebral cortex

Multiple radial glia cell classes establish parallel lineages in the developing cortex of mammals with the large and folded brain.

science.org
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Using in vivo CRISPR perturbation, lineage tracing, and ChIP–sequencing provides insight into how inhibitory neuron identity is determined in the developing germinal zone @edvoretskova • @chr_mayer • @MPIforBI nature.com/articles/s41593-0…

Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development

Nature Neuroscience - How genetic information in the germinal zone determines neuronal cell types is unclear. Here the authors show that MEIS2 plays an important role in determining GABAergic...

nature.com
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Excited to announce that our study "Spatial enhancer activation influences inhibitory neuron identity" is now online in Nature Neuroscience nature.com/articles/s41593-0… Big thanks to the Winkelmann (@HelmholtzMunich @TU_Muenchen) & Torres (@CNIC_CARDIO) labs for the collaboration! 1/7

Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development

Nature Neuroscience - How genetic information in the germinal zone determines neuronal cell types is unclear. Here the authors show that MEIS2 plays an important role in determining GABAergic...

nature.com
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In Bandler et al. we showed that in the GE single cell trajectories of projection and interneurons diverge from a common pool of mitotic progenitors (doi.org/10.1016/j.conb.2023.…). We now show that MEIS2 expression is the strongest predictor of projection neuron fate. 2/7
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Here is the correct link to the Bandler et al. paper: nature.com/articles/s41586-0…

Single-cell delineation of lineage and genetic identity in the mouse brain

Nature - Single-cell RNA sequencing with parallel tagging of progenitor cells is used to track clonal relationships and transcriptomic signatures during development of the mouse forebrain.

nature.com
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Looking forward to diving into the final version of this work. Excited that others also find differential binding as a chromatin strategy for alternative cell fate choice.
Christian Mayer (@[email protected])@chr_mayer25 Mar 2024
Replying to @chr_mayer
Enhancers that drive projection neuron-specific gene expression are accessible in all parts of the GE (ATAC-seq Rhodes et al). Yet, their activity is restricted to the LGE. Thus, "differential TF binding" rather than "differential accessibility" induces projection neuron fate 6/7
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A team led by Christian Mayer discovered that a protein called MEIS2 plays a crucial role in the formation of GABAergic projection neurons. These neurons enable various brain functions, and a failure of MEIS2 to control their development may contribute to neurodevelopmental disorders. Read more: bi.mpg.de/news/2024-03-mayer @chr_mayer
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Enhancers that drive projection neuron-specific gene expression are accessible in all parts of the GE (ATAC-seq Rhodes et al). Yet, their activity is restricted to the LGE. Thus, "differential TF binding" rather than "differential accessibility" induces projection neuron fate 6/7
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Thanks to a fantastic team for making this work possible, especially @edvoretskova, @MayHo_, Volker. @ERC_Research for the funding! @MPIforBI for support in the establishment of our research group. 7/7
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