doing some science | using cryo-ET to study tissues in situ ❄️🔬 | @OxCellStruBio @RosFrankInst
Joined October 2019
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Jake Smith retweeted
Subtomogram averaging from lamellae
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Jake Smith retweeted
Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells!
biorxiv.org/cgi/content/shor…
Jake Smith retweeted
Our Wellcome-funded PhD program in Structural Biology is accepting applications. Join us. Excellent training and some wonderful research projects in Oxford, Diamond Light Source and the Rosalind Franklin Institute. Come to be part of our vibrant, diverse, supportive program!
Jake Smith retweeted
What do dynamic protein complexes look like *inside the cell*? Excited to share our work, led by superstar @ramyarangan, on cryoDRGN-ET, a new approach in the ❄️🐉 software for reconstructing and visualizing structures from in situ cryo-ET data. 1/
biorxiv.org/content/10.1101/…
Jake Smith retweeted
🔥 Today, researchers unveiled the connectome of the male adult fruit fly nerve cord.
🧠 With about 23K neurons, 10 million pre-synaptic sites & 74 million post-synaptic densities, it’s the most in-depth & complete wiring diagram of a fly nerve cord.
🔗janelia.org/news/janelia-sci…
Jake Smith retweeted
Preparing some videos for upcoming talks. I'll be in Aarhus and Cambridge in the next couple of weeks. Lots of talking about EM data inside of #blender3d using #MolecularNodes and #GeometryNodes to create clear visuals and beautiful animations.
Feels cool to zoom around a cell
Jake Smith retweeted
Ever wondered how to get to the region of interest for cryoET? Fear not! @janetiwasa @shen_utah and I just released Chapter 3 of cryoET101 ! Check it out: cryoem101.org/chapter-3-et/. Enjoy beautiful animations like waffle milling by @torrez_rach! We welcome your feedback. #Teamtomo
Jake Smith retweeted
For the first time, this week #EMDB released five #CryoEM structures from #HendrixVirus genus. Study by Hawkins EDPD et al., on HK97 Portal Protein in-situ (prohead II) @ 2.97 Å
Jake Smith retweeted
Since people like 🇮🇹 salami slicing😉: I am very happy to share with you the first work of my lab @humantechnopole: Serialized On-grid Lift-In Sectioning for Tomography - SOLIST🔬❄️If you're into cryo-ET of 🧠 organoids, look no further!
Work by Gaia Perone and Jasmien Nguyen!🎵
Jake Smith retweeted
We are hiring an expert in Cryogenic Tissue Workflows!
Find out more and apply here - zurl.co/Fv3l
#teamtomo
ALT Text in graphic reads "We are hiring. We are currently on the lookout for a Senior Scientist in Cryogenic Tissue Workflows who will build on our recent work in demonstrating the use of focused ion beams to image cells and tissues."
Jake Smith retweeted
Every virologist thinks they have the prettiest virus in their lab . Here is the beautiful crAss001, solved by Cryo-EM in a collaboration with Oli Bayfield and Fred Antson in York @UniOfYork. @Pharmabiotic @UccMicrobiology @AShkoporov @scienceirel
nature.com/articles/s41586-0…
Jake Smith retweeted
Met Gala 2023 as Quantifoil #cryoem grids. A short thread
1/7 Stella McCartney as R 1/4
ALT Left hand side Stella McCartney in Dinner Jacket with regular crystal patterning and glittery tights. Right Hand Side Close up of Quantifoil cryoem support film with R 1/4 geometry
Jake Smith retweeted
Glad to finally share our manuscript on “Serial Lift-Out” by the amazing twitterless Oda Schiøtz, Jürgen Plitzko, @CJOKaiser , and myself. Doing multiple sections from single lift outs showing beautiful C. elegans ultrastructure 🤯 I could watch it all day 🤩How did we get there?
Jake Smith retweeted
This weeks #EMDB release includes this beautiful 4.4 Å #SingleParticle #CryoEM structure of a phicrAss001 #virion!
EMDB: ebi.ac.uk/emdb/EMD-14100
@AShkoporov @dorothy_edph @crying_EM @eugene_koonin
Jake Smith retweeted
In situ structure of the red algal phycobilisome–PSII–PSI–LHC megacomplex nature.com/articles/s41586-0…
Jake Smith retweeted
Asgard archaea reignited discussions about the tree of life 🦠 But do they have eukaryotic features? YES!! 🤩 Check out our new paper @Nature by @F_Wollweber and @xujw_thu, in an exciting collaboration with the Schleper lab @Archaea_Vienna. nature.com/articles/s41586-0…
🧵1/4
Jake Smith retweeted
Our @wellcome funded PhD program in Cellular Structural Biology is open for applications. Great science. Great mentors. Great facilities. Inclusive, supportive program. Come to join us and learn to find out how life works at a molecular level.
Jake Smith retweeted
A pleasure to have Julia speak to us today!
Great seminar from Julia Mahamid from @EMBLHeidelberg speaking at @RosFrankInst today. Julia has been and is a pioneer of cell based structure biology. Just amazing work.