Cheng-Yi Lee, PhD. retweeted
北海道 定点あたり報告数
インフルエンザは全国2番目に多い
コロナは全国最多
です...😢
コロナによる入院患者さんも増加傾向
【道内の感染症情報】
iph.pref.hokkaido.jp/kansen/…
定点把握感染症の流行状況
2026年 第44週(10月26~11月1日)
⚠️インフルエンザ注意報発令中!
第41週(10月5~11日)より継続
(警報 : 9保健所、注意報 : 14保健所)
警報レベルなし
Cheng-Yi Lee, PhD. retweeted
PJ.2.1
• First detected in Canada in May 2026
• Spreading across the US, Europe and Asia
• Symptoms resemble a cold or flu
• The WHO says there is no evidence of more severe illness
• Older adults & people with weakened immune systems or chronic conditions face higher risk

ALT News article preview titled “Coronavirus PJ.2.1: symptoms and what is known about the risks.” • Image shows two round coronavirus particles with orange centres and red spike-like structures against a beige background. • Headline discusses the COVID-19 variant PJ.2.1 and its potential health risks. • Description states the variant is spreading worldwide. • Article explores symptoms, differences from the flu and what the WHO is saying. • Source: ukrmedia.news.
Cheng-Yi Lee, PhD. retweeted
C'est toujours impressionnant : quasiment une personne âgée (d'au moins 75 ans) sur 2 s'est désormais fait vacciner contre le #Covid19 cet automne en Angleterre.
Outre-Manche, la vaccination Covid chaque année est devenue presque aussi habituelle que celle contre la grippe.
1/2
Cheng-Yi Lee, PhD. retweeted
South Korea confirms H5N1 bird flu at 260,000-hen layer farm in Gyeonggi's Yeoju, third farm outbreak this month
efeedlink.com/articles/south…
Cheng-Yi Lee, PhD. retweeted
Preprint: Limiting COVID vaccines to 65+ could raise hospitalizations 23–27% across all ages.
➡️Modelling (Illinois data) shows vaccinating younger adults & children cuts transmission enough to meaningfully protect higher-risk older adults.
Restricting eligibility to 65+ only increases infections (especially in kids) and hospitalizations (especially in the elderly) over multi-year horizons!
➡️Those indirect effects matter!
➡️The authors note that serious vaccine side effects are rare. Therefore, any reduction in side effects from limiting eligibility would not outweigh the resulting increase in COVID hospitalizations.
medrxiv.org/content/10.64898…
Cheng-Yi Lee, PhD. retweeted
Seals sleep underater with a kind of auto-pilot.
Every twenty minutes, an automatic reflex brings these sleeping seals to the surface for air. Their brain acts like a biological autopilot, allowing them to breathe and sink back down without ever waking up.
This aquarium time lapse shows this behavior.
Cheng-Yi Lee, PhD. retweeted
#H5N1
➡️⚠️ U.S. Global Health Strategy Jeopardizes Prevention of Pandemics, Experts Warn
- The Trump administration has been negotiating agreements with dozens of individual countries. Public health experts say a global agreement would be far more effective.
- ➡️ Country by country, the Trump administration has been negotiating secretive agreements with nations across Africa to provide health aid under strict conditions. ➡️ The agreements, ➡️ structured to benefit the United States, ➡️ are undermining efforts to prepare the world for the next pandemic, putting even Americans at risk, public health experts warn.
- In one striking example, under an agreement signed in February that was never made public, ➡️ the United States is set to stop funding health care workers in the Democratic Republic of Congo by the end of the year. Congo has been struggling to contain an Ebola outbreak that has topped 10,000 cases and has spread to two other regions of Africa.
- The plan, a copy of which was obtained by The New York Times, provides Congo with $900 million over the next five years, and was signed before the Ebola outbreak was detected.
- Still, several public health experts said it was an example of ➡️ the Trump administration’s focus on near-term benefits for the United States over the long-term partnerships needed to weather international crises.
- “They have shown incredibly poor foresight proposing further cuts right where workers are needed to fight infectious threats that we all know are coming,” said Peter Maybarduk, the director of access to medicines for the advocacy group Public Citizen.
- In response to questions from The New York Times, the State Department said it would work with Congolese officials to ensure they can pay government health workers, but did not say whether it would grant an extension on the Dec. 31 deadline.
- ➡️ The administration has signed ➡️ 36 such agreements so far, but ➡️ has not released them publicly. Some agreements, including most recently for Botswana, Cameroon, Eswatini, Ethiopia, Congo and Lesotho, were obtained by Public Citizen through a freedom of information request and made available to The Times.
- The State Department has said it ➡️ intends to eventually sign agreements with about 70 countries across the developing world.
- ➡️ “One deal at a time risks building 50 slow systems instead of one fast one,” said Dr. Raj Panjabi, who served as the White House’s senior director for global health security and biodefense during the Biden administration. ➡️ “The only way to see that new biological threat fast is a global system where every country is expected to share, and where the U.S. is at the table helping write those rules.”
- The next grave health threat could come from a country that has not signed a deal with the United States, he said, or it could be an accidental or deliberate release, perhaps of a pathogen engineered to be more deadly.
- The State Department said partnerships with individual countries and regions deliver faster results, and are more accountable, than multilateral agreements.
- Dr. Panjabi helped write ➡️ the newest version of the International Health Regulations, ➡️ a legally binding set of rules for countries to detect and disclose outbreaks that could breach borders. ➡️ Member nations of the World Health Organization began following those rules last year. (The rules have since prompted disclosure of the hantavirus outbreak in May and the accidental death of a lab worker in Serbia last month.)
- ➡️ But the Trump administration, which ➡️ withdrew the United States from the W.H.O. in January 2025, ➡️ rejected the regulations, inaccurately saying they “would give the W.H.O. the ability to order global lockdowns, travel restrictions, or any other measures it sees fit” during a public health emergency.
- ➡️ The United States, along with Israel and Argentina, ➡️ also rejected an agreement last month by member countries of the United Nations ➡️ that pledged collaboration and solidarity in responding to pandemics.
- ➡️ “The United States just seems really determined to increase our vulnerabilities by sitting out of the most important conversations,” said Jennifer Nuzzo, a co-developer of the Global Health Security Index, which assesses pandemic preparedness in countries.
- Since the Covid-19 pandemic, in which low-income nations lagged richer ones by more than a year in gaining access to vaccines, members of the W.H.O. have been ➡️ trying to hammer out a global treaty that would allow for faster, more equitable access to diagnostic tests, vaccines and treatments the next time. They have until May to finalize the terms.
.
- But the path to consensus has been rocky. In negotiations, including this week in Geneva, ➡️ low-income nations, including a coalition of African countries, are holding out for guarantees of early and affordable access to medical tools in return for sharing information. ➡️ Higher-income nations are trying to shield intellectual property rights.
- ➡️ The United States was involved in the global discussions until President Trump withdrew the nation from the W.H.O. on his first day back in the White House. The administration also cut much of the foreign aid the country disbursed to low-income nations, instead pursuing bilateral deals with countries as part of its “America First Global Health Strategy.”
- ➡️ At least 11 of the new agreements, including the one with Congo, include ➡️ requirements to share information from outbreaks in exchange for foreign aid.
- ➡️ They require countries to share specimens and related data from an outbreak within five days of receiving a request from the United States. Under the terms, the United States then can share that information with other entities — pharmaceutical companies, for example — that can develop tests and medical countermeasures.
- But ➡️ the agreements do not guarantee early or equitable access to the new tests, treatments or other tools that might result. Many give the United States direct access to national health databases, but without privacy protections or oversight from civil society organizations.
- The agreements instead say the United States would “prioritize” providing the country with medical tools “behind the U.S. government’s domestic need” and at costs “equal to or below those paid by” the United States.
- By contrast, ➡️ the global agreement, once finalized, would provide affordable medical tools to all low-income nations, not just the one that provides information.
- Some experts worried that by setting up a parallel process, the American agreements would undermine the already contentious global negotiations.
- “The bilateral approach will weaken the effort we are doing to bring the continent together,” said Dr. Jean Kaseya, director general of the Africa Centers for Disease Control and Prevention.
- Dr. Kaseya said he advised African ministers to agree to the bilateral deals only if they were satisfied with the terms, and helped some countries like South Sudan negotiate more “respectful” language. But ultimately, he said, “we need to respect sovereignty of our countries.”
- A few countries, including Zimbabwe and Namibia, rejected the Trump administration’s demands, saying the terms violated their sovereignty or their laws. The United States withdrew all health aid from Zimbabwe as of Sept. 30, and announced that it would stop funding H.I.V. programs in Namibia after 2027.
- Other countries successfully pushed for more favorable terms than their contracts initially proposed. Zambia’s agreement, signed after 10 months of negotiation, is no longer contingent on the Trump administration’s access to Zambia’s minerals, and does not require the country to share information on pathogens for 25 years.
- But ➡️ many countries that rely on aid from the United States are not in a position to fight back and forgo aid, Mr. Maybarduk noted.
- ➡️ “This is the take-it-or-leave-it deal that the United States has put in front of them in order to restart some of the health funding that was taken away,” he said. “These are the offers you can’t refuse.”
- Dr. Samu Bijou Pekwa, chief of staff in Congo’s health ministry, said her country welcomed the agreement with the United States because it would give local officials more control over the funds. American aid was previously carried out by organizations that gave the Congolese government little say over how the money was spent, she said. The organizations were “not even involving us,” she added.
- According to the memorandum of understanding with Congo, the United States plans to stop paying health care workers “by the end of 2026, costing $12,025,689,” transitioning that responsibility to the Congolese government.
- Dr. Pekwa said Congo and other international partners can take over the payments but the government must ensure the workers exist and then confirm their credentials. That process will take at least six months, she said.
- The State Department noted that the United States is the largest donor to the current Ebola response, contributing more than $1.2 billion in health and humanitarian assistance. But experts have said that the loss of logistical and scientific support, once provided by the U.S. Agency for International Development and the U.S. Centers for Disease Control and Prevention, has hindered efforts to contain the outbreak.
- Yet some public health experts saw ➡️ reasons for optimism.
- Some money for logistics, including transport and testing of patient samples, has come from ➡️ the Pandemic Fund, set up in 2022 to move money quickly in outbreak situations. ➡️ The fund now has a portfolio of $11.5 billion of investment across 128 countries, according to Priya Basu, its director.
- She added that new sources, including private companies and countries that have not traditionally been large donors, now seem poised to invest in the fund.
- Other experts noted that low- and middle-income countries were learning to collaborate — pooling their resources, expertise and purchasing power — rather than rely on richer nations.
- “I think it was just laid bare during Covid that they were on their own,” said Rachel Cohen, a senior adviser for the Drugs for Neglected Diseases Initiative.
- ➡️ “There is such an incredible amount of work that’s happening at the national level, at the regional level, at the continental level,” she said. ➡️ “Nobody is waiting around for the U.S. to lead anymore in the same way as before.”
By Apoorva Mandavilli
nytimes.com/2026/11/06/us/po…
Cheng-Yi Lee, PhD. retweeted
🚨🐄 With growing alarm over the renewed spread of 𝙱𝟹.𝟷𝟹 H5N1 in US dairy herds, the recent spillover into a Utah mink farm, and ongoing human cases, the #1 question remains:
𝗜𝘀 𝘁𝗵𝗶𝘀 𝘃𝗶𝗿𝘂𝘀 𝗼𝗻 𝗮 𝗽𝗮𝘁𝗵 𝘁𝗼 𝗲𝘃𝗼𝗹𝘃𝗲 𝗵𝘂𝗺𝗮𝗻-𝘁𝘆𝗽𝗲 (α𝟮–𝟲) 𝗿𝗲𝗰𝗲𝗽𝘁𝗼𝗿 𝗯𝗶𝗻𝗱𝗶𝗻𝗴?
Yet after 2 years and thousands of mammal-to-mammal infections across cows, cats, mink, and wildlife, the main 𝙱𝟹.𝟷𝟹 lineage still hasn’t budged toward α𝟸–𝟼.
Here’s my current thinking on why — and why 𝙱𝟹.𝟷𝟹’s unprecedented mammalian host breadth might actually be pushing it in the opposite direction, 𝗹𝗼𝗰𝗸𝗶𝗻𝗴 𝗶𝘁 𝗱𝗲𝗲𝗽𝗲𝗿 𝗶𝗻𝘁𝗼 𝗯𝗶𝗿𝗱-𝘁𝘆𝗽𝗲 (α𝟮–𝟯) 𝗯𝗶𝗻𝗱𝗶𝗻𝗴:
────────────────────
🔑 𝗤𝘂𝗶𝗰𝗸 𝗥𝗲𝗰𝗲𝗽𝘁𝗼𝗿 𝗥𝗲𝗳𝗿𝗲𝘀𝗵𝗲𝗿
Flu enters cells by grabbing sialic acid sugars (𝙷𝙰) and exits by cutting them (𝙽𝙰):
• 🦆🐄 α𝟸–𝟹 (𝗯𝗶𝗿𝗱-𝘁𝘆𝗽𝗲): Dominant in bird guts/airways, deep human lung, eye — and the 𝗰𝗼𝘄 𝗺𝗮𝗺𝗺𝗮𝗿𝘆 𝗴𝗹𝗮𝗻𝗱.
• 👃🧑 α𝟸–𝟼 (𝗵𝘂𝗺𝗮𝗻-𝘁𝘆𝗽𝗲): Dominant in the human nose & upper throat (where cough/sneeze transmission happens).
Historically, avian flu needed to flip 𝙷𝙰 from α𝟸–𝟹 to α𝟸–𝟼 (often via 𝚀𝟸𝟸𝟼𝙻) to spread between humans. Why hasn’t mammal-to-mammal spread in cattle nudged 𝙱𝟹.𝟷𝟹 toward α𝟸–𝟼?
────────────────────
🔒 𝟭. 𝗧𝗵𝗲 𝗖𝗼𝗺𝗺𝗼𝗻-𝗗𝗲𝗻𝗼𝗺𝗶𝗻𝗮𝘁𝗼𝗿 𝗧𝗿𝗮𝗽 𝗼𝗳 𝗮 𝗠𝘂𝗹𝘁𝗶-𝗛𝗼𝘀𝘁 𝗚𝗲𝗻𝗲𝗿𝗮𝗹𝗶𝘀𝘁
𝙱𝟹.𝟷𝟹 isn’t evolving in an isolated upper-airway niche. In the tree of >5,600 genomes (thanks @nextstrain):
• 🔀 𝟮𝟳𝟵+ 𝘀𝗽𝗶𝗹𝗹𝗯𝗮𝗰𝗸𝘀 from cattle into wild birds, poultry, barn cats, raccoons, skunks, rodents & mink
• ↩️ 𝟴𝟳 𝗯𝗮𝗰𝗸-𝘀𝗽𝗶𝗹𝗹𝗼𝘃𝗲𝗿𝘀 from birds back into cattle
Across 𝗮𝗹𝗹 of those niches — cow udders, bird guts, poultry, and carnivore/mink lungs — α𝟸–𝟹 is the shared entry receptor!
In lab studies on 𝙱𝟹.𝟷𝟹 𝙷𝙰, forcing in the human-type 𝚀𝟸𝟸𝟼𝙻 mutation collapses α𝟸–𝟹 binding and destabilizes the 𝙷𝙰 trimer. In a virus cycling between cow udders and farm wildlife, any mutant that trades α𝟸–𝟹 for α𝟸–𝟼 immediately loses fitness in the very tissues keeping the chain alive.
🧬 𝟮. 𝗕𝗲𝗰𝗼𝗺𝗶𝗻𝗴 𝗮𝗻 α𝟮–𝟯 𝗦𝘂𝗽𝗲𝗿-𝗚𝗲𝗻𝗲𝗿𝗮𝗹𝗶𝘀𝘁 𝗜𝗻𝘀𝘁𝗲𝗮𝗱
Rather than shifting toward α𝟸–𝟼, clade 𝟸.𝟹.𝟺.𝟺𝚋 expanded its host range by making its binding pocket more flexible:
𝙺𝟸𝟸𝟸𝚀 → 𝚃𝟷𝟿𝟿𝙸 → 𝙳𝟷𝟶𝟺𝙶 → 𝚅𝟷𝟺𝟽𝙼
This lets 𝙷𝙰 grab a wider variety of α𝟸–𝟹 sugars (fucosylated, branched, and cattle NeuGc variants) while keeping α𝟸–𝟼 affinity near zero.
✂️ 𝟯. 𝗖𝗼-𝗘𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻𝗮𝗿𝘆 𝗟𝗼𝗰𝗸-𝗜𝗻 𝗪𝗶𝘁𝗵 𝗡𝗔
As 𝙱𝟹.𝟷𝟹 𝙷𝙰 tightened its grip on α𝟸–𝟹 sugars in cattle, the viral scissor protein (𝙽𝙰) co-evolved matching mutations:
𝙽𝙰: 𝙺𝟷𝟷𝟷𝚁 | 𝚃𝟽𝟸𝙰 | 𝙽𝟺𝟹𝟺𝚂 | 𝙺𝟺𝟹𝟸𝙴
(𝙽𝟺𝟹𝟺𝚂 & 𝙺𝟺𝟹𝟸𝙴 sit right in 𝙽𝙰’s secondary helper pocket that grabs α𝟸–𝟹 sugars). Once 𝙷𝙰 and 𝙽𝙰 are co-tuned for α𝟸–𝟹, switching 𝙷𝙰 alone to α𝟸–𝟼 breaks their balance.
────────────────────
⚠️ 𝗧𝗵𝗲 𝗖𝗼𝘂𝗻𝘁𝗲𝗿-𝗔𝗿𝗴𝘂𝗺𝗲𝗻𝘁: 𝗪𝗵𝘆 𝗪𝗲 𝗖𝗮𝗻’𝘁 𝗥𝗲𝗹𝗮𝘅
Even if the cow–bird–mammal cycle locks the 𝗺𝗮𝗶𝗻 𝘁𝗿𝘂𝗻𝗸 into α𝟸–𝟹, three things make the resurgence, mink farm outbreak & human cases genuinely concerning:
⚙️ 𝟭. 𝗧𝗵𝗲 𝗶𝗻𝘁𝗲𝗿𝗻𝗮𝗹 𝗺𝗮𝗺𝗺𝗮𝗹𝗶𝗮𝗻 𝗲𝗻𝗴𝗶𝗻𝗲 𝗶𝘀 𝗮𝗹𝗿𝗲𝗮𝗱𝘆 𝗯𝘂𝗶𝗹𝘁:
Two years in cows fixed mammalian polymerase adaptations (𝙿𝙱𝟸:𝙼𝟼𝟹𝟷𝙻, 𝙿𝙰:𝙺𝟺𝟿𝟽𝚁) and a 4-mutation interferon-stealth stack in 𝙽𝚂𝟷 (𝙰𝟼𝟶𝚃 + 𝚀𝟸𝟻𝚁/𝙸𝟻𝟺𝙻/𝙴𝟽𝟶𝙰/𝙼𝟷𝟸𝟺𝚃) — and in Utah mink it immediately stacked 4 more (𝙿𝙱𝟸:𝚀𝟷𝟹𝚁, 𝙿𝙱𝟷:𝙺𝟹𝟾𝟾𝚁, 𝙿𝙰:𝙸𝟷𝟸𝟿𝚃, 𝙼𝟸:𝙶𝟻𝟾𝙳/𝚂𝟼𝟺𝙵). Spillovers no longer start from scratch.
🪜 𝟮. 𝗖𝗮𝘁𝘁𝗹𝗲 𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻 𝗸𝗲𝗲𝗽𝘀 𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗶𝗻𝗴 𝘀𝘁𝗲𝗽𝗽𝗶𝗻𝗴-𝘀𝘁𝗼𝗻𝗲 𝗛𝗔 𝘃𝗮𝗿𝗶𝗮𝗻𝘁𝘀:
In 𝙱𝟹.𝟷𝟹 𝙷𝙰, 𝚀𝟸𝟸𝟼𝙻 works poorly alone, but gives clean human α𝟸–𝟼 binding when paired with 𝙰𝟷𝟽𝟸𝚃 (𝚃𝟷𝟼𝟶𝙰, which deletes a nearby sugar shield). In cattle, 𝙰𝟷𝟽𝟸𝚃 has already arisen ~𝟭𝟬 𝗶𝗻𝗱𝗲𝗽𝗲𝗻𝗱𝗲𝗻𝘁 𝘁𝗶𝗺𝗲𝘀 (#2 selected site in 𝙷𝙰).
🌿 𝟯. 𝗗𝗲𝗮𝗱-𝗲𝗻𝗱 𝘀𝗽𝗶𝗹𝗹𝗼𝘃𝗲𝗿𝘀 & 𝗿𝗲𝗮𝘀𝘀𝗼𝗿𝘁𝗺𝗲𝗻𝘁 𝗱𝗼𝗻’𝘁 𝗰𝗮𝗿𝗲 𝗮𝗯𝗼𝘂𝘁 𝘂𝗱𝗱𝗲𝗿 𝗳𝗶𝘁𝗻𝗲𝘀𝘀:
A virus that spills into a human or pig — or reassorts with seasonal/swine flu — is in an α𝟸–𝟼 upper airway and never has to cycle back into a cow udder or a bird.
────────────────────
💡 𝗧𝗮𝗸𝗲𝗮𝘄𝗮𝘆
Expecting the 𝗰𝗮𝘁𝘁𝗹𝗲 𝗿𝗲𝘀𝗲𝗿𝘃𝗼𝗶𝗿 𝗶𝘁𝘀𝗲𝗹𝗳 to gradually drift toward α𝟸–𝟼 probably misreads what selection in cows and farm wildlife rewards — which is locking in α𝟸–𝟹. The real risk isn’t where the main cattle trunk is heading, but that expanding mammal circulation keeps feeding a pre-adapted internal engine + permissive 𝙷𝙰 variants into side-branch exposures.
Key papers in reply 👇
Replying to @RC135V @JoshuaBarzon
Even better an interactive website entireworldhistorytimeline.c…
Cheng-Yi Lee, PhD. retweeted
5,000 years of world history on a single timeline. Zoom in. You could spend 30 minutes exploring this.
Cheng-Yi Lee, PhD. retweeted
“Cattle movement consistently explained interstate viral spread more strongly than geographic proximity”
— Discussion, p. 18
“we found no evidence that wild birds contributed to the geographic spread of B3.13 among dairy cattle.”
— Discussion, p. 18
“each week of delay in policy implementation was associated with an additional median 11–12 infected counties per week”
— Counterfactual simulations, PDF p. 16
“Real-time effluent or wastewater monitoring could reduce detection times further still, potentially to days rather than weeks or months.”
— Discussion, p. 20.
Cheng-Yi Lee, PhD. retweeted
Islamic State-linked militants raided a village in eastern Democratic Republic of Congo, killing at least 33 civilians and forcing patients with confirmed and suspected Ebola infections to flee, authorities said on Friday. reuters.com/world/africa/isl…
Cheng-Yi Lee, PhD. retweeted
Horrific. At least 33 civilians killed and Ebola patients forced to flee.
Healthcare must never be a target.
We cannot control this outbreak without security for communities, patients, and health workers.
Islamic State-linked militants raided a village in eastern Democratic Republic of Congo, killing at least 33 civilians and forcing patients with confirmed and suspected Ebola infections to flee, authorities said on Friday. reuters.com/world/africa/isl…
Cheng-Yi Lee, PhD. retweeted
Pulmonary vascular abnormalities in Long COVID: a radiological perspective
🚨Your CT is ‘normal,’ yet you’re still breathless months after COVID. New review shows hidden microvascular damage (perfusion defects, vessel pruning, gas-transfer defects) that standard scans miss, explaining LongC0VID symptoms that routine imaging miss!
➡️Interesting new narrative review from India shifts the focus of LongC0VID from parenchymal lung damage to a distinct pulmonary vascular phenotype! REMEMBER SARSCOV2 is basically a VASCULAR VIRUS!
➡️Core mechanisms:
- SARSCoV2 enters endothelial cells via ACE2 receptors, triggering endotheliitis that creates a pro-coagulant environment and promotes the formation of in-situ microthrombi,
- This is amplified by immunothrombosis (driven by neutrophil extracellular traps) and the generation of amyloid-like fibrin microclots that resist normal breakdown,
- Over time, the vasculature undergoes maladaptive remodelling, including intussusceptive angiogenesis and progressive “pruning” of small vessels, which reduces the available surface area for gas exchange,
➡️Conventional CT pulmonary/angiography frequently appears normal or near-normal and misses microvascular disease,
➡️Advanced imaging uncovers the pathology:
1. Dual-energy CT (DECT) detects persistent wedge-shaped perfusion defects in otherwise normal lung tissue, seen in 36–60% of symptomatic patients and still present in 36.3% at roughly 3 months,
2. Quantitative CT shows reduced small-vessel volume (PBV5), which correlates with lower DLCO and poorer exercise tolerance,
3. Hyperpolarized xenon-129 MRI reveals a hallmark gas-transfer defect, impaired alveolar-to-RBC gas exchange, even when standard CT and pulmonary function tests appear normal,
4. V/Q SPECT and PREFUL MRI demonstrate mottled perfusion patterns consistent with diffuse small-vessel disease,
➡️Findings correlate with ongoing dyspnoea, fatigue, and reduced exercise capacity,
➡️Higher (admission) D-dimer/CRP often predict later defects,
➡️2025 RSNA/STR/ESTI consensus guidelines recommend imaging at 3 months with paired inspiratory/expiratory protocols and the term “Post-COVID-19 Residual Lung Abnormality.”
‼️So, AGAIN, routine CT scans can look reassuring while the pulmonary microvasculature remains structurally and functionally damaged, directly accounting for persistent breathlessness and fatigue in a substantial subset of LongC0VID patients.
‼️The proposed framework matters clinically every day: many patients with ongoing dyspnoea or exercise intolerance after COVID have occult vascular injury that conventional imaging and basic Pulmonary Function Tests(PFTs) fail to detect. Recognizing the vascular phenotype guides use of functional/quantitative techniques (DECT, xenon MRI, etc.), supports standardized 3-month imaging protocols, and should shift management toward vascular rather than purely parenchymal explanations. It also helps differentiate vascular from airway-related causes of symptoms and UNDERSCORES the public-health scale of residual impairment in survivors!
REMINDER AGAIN, COVID-19(SARSCOV2) is basically a VASCULAR INFECTION!
#AvoidSars2 #AvoidReinfections #Mitigation
link.springer.com/article/10…
Cheng-Yi Lee, PhD. retweeted
PJ.2.1: 39%
This chart shows biweekly trends of SARS-CoV-2 variants detected in nasal swab samples collected from arriving international travelers.
From Traveler-Based Genomic Surveillance Data, the U.S. CDC
cdc.gov/traveler-genomic-sur…
JPさんによる米国の下水ウイルス量を感染者に換算したやつ(累計)
米国人口を3億4千万人とすると、累計で12億人(回)が感染したと😱
現時点から遡って1年ごとに青線引いてみました。
ざっくり、2025年以降は徐々に鈍化していますね。今のところ
Replying to @JPWeiland
This calibration implies about ~3.5 infections per capita in the US since 2020. It has slowed down a lot since the large waves in 2022 through 2024, but continues to accumulate over time.
Cheng-Yi Lee, PhD. retweeted
The H5N1 avian flu claims one life in the United States and reopens concerns about its evolution in humans
gacetamedica.com/investigaci…
Cheng-Yi Lee, PhD. retweeted
NEW STUDY: Scientists Warn of H5N1 Bird Flu Pandemic Threat, Highlighting Critical Research Gaps and Europe’s Need to Strengthen Preparedness
sciencedirect.com/science/ar…
Cheng-Yi Lee, PhD. retweeted
11/5日、韓国が44件のseq データを提出。検体採取は9/3~10/7。44件中43件がNB.1.8.1系統(他の1件はXFG*のSW.2.1)で、内訳は下表の通りです。最下位の系統名 (Sub-lineage)はNextcladeの分類に従いました。
NB.1.8.1系統が圧倒的なシェアを占めているのは韓国に限らず、中国、シンガポールなどアジア地域で広く見られ、日本でもBA.3.2からNB.1.8.1*への置き換わりが進みつつあります。これは、XFGの多様な亜系統が分化し、支配的なシェアを占める多くの欧米諸国の状況とは対照的です。







































