Drug discovery | Computational Biology | Human Disease Genetics | ML | Cloud computing - @opentargets - @emblebi
Cambridge, England
Joined November 2011
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Great chat with @patrick_j_short on finding new drug targets by leveraging human genetic information in a public-private partnership. Thanks to @sanogenetics
Episode 112 of The Genetics Podcast is live! 🚀
This week, we sit down with @d0choa, Platform Coordinator @OpenTargets, to discuss how their platform is enabling game-changing collaboration between academic research & big pharma.
Listen here 👇
pod.fo/e/204ce7
David Ochoa retweeted
Excited to share our latest work. Applying advanced single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune lymphocytes. [1/n] rdcu.be/fdqbr
The @OpenTargets Platform spring 🌼 release is out — and this one marks the beginning of something we've been building towards for a while.
Other highlights:
🧬 ENCODE-rE2G scores now in L2G → 5% gain in selectivity
📊 710 new GWAS Catalog studies → 5,000+ new credible sets (incl. Rand et al., Nat Genet 2025)
⚡ ClickHouse migration complete → ~2x query speed
☁️ Platform data now on AWS Open Data Program
Thank you to all our data providers, partners, and the @OpenTargets core team who make this possible. 🙏
🚀 Announcing the Official @OpenTargets MCP!
We've partnered with @AnthropicAI to provide AI with seamless access to high-quality genetics and target-discovery data. Open for the entire community to accelerate therapeutic development
blog.opentargets.org/officia…
The @OpenTargets Platform Spring 🌼 release brings a step-change in how we address common disease genetics. We included the results of a large-scale analysis on GWAS and functional genomics studies to inform target selection further 🧬👩💻
blog.opentargets.org/a-step-…
David Ochoa retweeted
Thrilled to see our work on murine oesophageal #Epithelioids published in @NatureGenet, after many years of hard work alongside @AlbertHerms during our postdoc at Phil Jones' lab @Sangerinstitute and built on the foundational work by @MariaPAlcolea
nature.com/articles/s41588-0…
The Open Targets Platform autumn release 🍁 is full of new data and UI features. This is the last update before we make a giant leap forward in our common genetic evidence 🧬
We have been working hard to blend the best of Open Targets Platform and Open Targets Genetics into a single product that will unify our thinking about genetically informed target identification.
David Ochoa retweeted
Job alert 🚨: join us for a post-doc in beautiful Cambridgeshire !
Postdoc Opportunity. Join the Saez Rodriguez group! Develop computational methods to explore cellular organization & disease mechanisms using multi-omic data. #Postdoc
embl.org/jobs/position/EBI02…
David Ochoa retweeted
Join the Club! 🤝
A new study characterises types of Open Science Partnerships, featuring Open Targets as an example of “The Club”
This research suggests how OSPs can best be designed for their goals, and provides a framework to understand their impact
nature.com/articles/s41599-0…
David Ochoa retweeted
Why do clinical trials stop?
Researchers from @OpenTargets and EMBL-EBI have developed a machine learning model to analyse clinical trial data. They found a correlation to suggest that trials less supported by genetic evidence are more likely to fail.
ebi.ac.uk/about/news/researc…
ALT Open Targets logo
David Ochoa retweeted
Genetic evidence halves the odds of early clinical trial stoppage 🧬💊
Published today in @NatureGenet, @lesya_rzvvsk trained a machine learning classifier to analyse the free-text reasons explaining why 28,842 clinical trials stopped
3 key points:
nature.com/articles/s41588-0…
