@DanielJDrucker

A clinician scientist at LTRI @sinaihealth studying GLP-1, diabetes, obesity and the gut endocrine system Proud 🇨🇦Not going anywhere Am 🇮🇱Chai

 Toronto
glucagon.com
Joined May 2011
  • Tweets33.1K
  • Following1.4K
  • Followers37K
7.9KMedia
How do GLP-1 meds improve liver health through #weightloss independent mechanisms? Here @ChusaGzlzRellan & colleagues identify Liver Sinusoidal Endothelial Cells as direct targets of semaglutide, linking LSECs to reduction of #inflammation #Fibrosis #MASH cell.com/cell-metabolism/abs…
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Retatrutide and the improvement of obstructive sleep apnea nejm.org/doi/full/10.1056/NE…

Retatrutide Once Weekly for Treatment of Obstructive Sleep Apnea | NEJM

Retatrutide, an investigational triple agonist of glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and glucagon receptors, may be useful for treating obstructive sleep apnea (...

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Eric Topol
@EricTopolOct 20
GLP-1 peptides protect the gut from immune injury. Essential role of endogenous GLP-1 family peptides to reduce inflammation and restore mucosal integrity in the experimental model @DanielJDrucker @CellRepMed cell.com/cell-reports-medici…
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Will GLP-1 medicines be useful in the clinic for substance use disorders? We will soon find out @marilenharo nature.com/articles/d41586-0…

Can GLP-1s heal the brain? Obesity drugs get a makeover for addiction and depression

Nature - Compounds inspired by the blockbuster weight-loss drugs are also being trialled for schizophrenia and Parkinson’s disease, among other conditions.

nature.com
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This Friday 8 am @SinaiHealth @uoftmedicine in Toronto, the 2026 Burrow Lecture, 8 am, Professor @cevansmo #Diabetes #islets
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Over 6 weeks in people with MASLD inhibition of fructose metabolism has beneficial metabolic effects that extend beyond the organs that metabolize fructose @NatMetabolism nature.com/articles/s42255-0…

Metabolic benefits of ketohexokinase inhibition in individuals with MASLD: a randomized placebo-c...

Nature Metabolism - In a randomized placebo-controlled crossover trial, pharmacological inhibition of ketohexokinase improved hepatic and systemic metabolic health in individuals with MASLD,...

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Here the authors propose that a gut microbial aldehyde-alcohol dehydrogenase, AdhE, converts metformin to pharmacologically inactive products, lowering intestinal and systemic drug exposure cell.com/cell-metabolism/ful… @Cell_Metabolism

Microbial aldehyde-alcohol dehydrogenase degrades metformin to limit therapeutic response in type 2...

Zhao et al. show that gut microbial aldehyde-alcohol dehydrogenase (AdhE) degrades metformin, reducing drug exposure and glycemic control in individuals with type 2 diabetes. A clinical trial further...

cell.com
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New P3 data for the oral small-molecule GLP-1 receptor agonist safiglipron in early type 2 diabetes in China @NatureMedicine nature.com/articles/s41591-0…

Oral small-molecule GLP-1 receptor agonist safiglipron in early type 2 diabetes: a randomized,...

Nature Medicine - The OUTSTAND-1 trial showed that once-daily oral small-molecule GLP-1 receptor agonist safiglipron reduced HbA1c by up to 1.45% versus placebo over 32 weeks in people with...

nature.com
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Genetic variation and type 2 #diabetes New perspectives @MolMetab sciencedirect.com/science/ar… @DiabetologiaJnl
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Max Kozlov@maxdkozlovSep 25
SCOOP: Top researchers at Columbia, Stanford, and others thought they were elected to elite scientific societies alongside Nobel laureates. The catch? The organizations are a sham. I spent the last month investigating a massive academic scam, for @Nature nature.com/articles/d41586-0…

Exclusive: Sham scientific societies are misleading star researchers

Nature - A Nature investigation reveals a network of organizations that have been building their ranks through deceptive practices.

nature.com
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A childhood window into genetic variation linked to childhood adiposity @NatureGenet nature.com/articles/s41588-0…

Genome-wide mapping of common and rare variant effects on adiposity across childhood

Nature Genetics - Genome-wide analyses identify common and rare variants associated with childhood adiposity, including rare protein-coding variants in ADCY3, CALCR, MC4R, MRAP2, POMC and MYH13...

nature.com
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Cohort studies across the lifespan for type 2 #diabetes Progress, clinical implementation and future directions @DiabetologiaJnl link.springer.com/article/10…

A narrative review of what cohorts have taught us and how they have laid the foundation for much of...

Diabetologia - This narrative review provides a historical perspective on how observational research on type 2 diabetes has been developed and consolidated over the last 50 years and how...

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Here the authors identify the glucagon-PKA-PDE2A-NCLX signaling axis as a key metabolic rheostat integrating mitochondrial calcium dynamics with lipid homeostasis, providing a promising therapeutic target for MASLD @MolMetab sciencedirect.com/science/ar…
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The weight loss proteome in mice nature.com/articles/s42255-0… @NatMetabolism

Multi-organ proteomic atlas of obesity regression in male mice

Nature Metabolism - A multi-organ proteomics resource of diet-induced obesity and its regression in male mice, spanning 15 organs and 4 timepoints, highlights systemic changes as well as...

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In an open label study for up to 26 weeks, dulaglutide was associated with greater improvements in glycaemic control and variability compared with insulin among adolescents with transfusion-dependent β-thalassaemia (TDT)-induced diabetes @DiabetologiaJnl link.springer.com/article/10…

Dulaglutide vs insulin in adolescents with thalassaemia-induced diabetes: effect on metabolism and...

Diabetologia - Chronic iron overload represents a significant morbidity in transfusion-dependent β-thalassaemia (TDT), leading to various complications, including diabetes and CVDs. The...

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From TMAO to DNICs the expanding concepts linking microbiota metabolism to cardiovascular and metabolic pathways. Modulating DNIC formation by the gut microbiota could be a strategy to support cardiometabolic health @CellCellPress cell.com/cell/fulltext/S0092…

Gut microbiota generate dinitrosyl iron complexes with cardiometabolic benefits

Gut bacteria convert inorganic nitrate and non-heme iron into bioactive dinitrosyl iron complexes (DNICs) that distribute systemically and signal independently of free nitric oxide. These microbe-d...

cell.com
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New studies in Drosophila and mice redefine the intestinal muscle as a responder to specific signals that adjust adult organ (intestine) features and sustain reproductive demands. cell.com/cell/fulltext/S0092…

The sex and reproductive plasticity of intestinal muscles instruct gut size

Adult intestinal size plasticity is driven not only by epithelial stem cells but also by remodeling of the surrounding visceral musculature. Sex- and reproduction-dependent muscle remodeling controls...

cell.com
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A framework identifying ten priorities in #T2D prevention, toward context-specific, actionable interventions capable of altering the natural history of disease early in the life course and restoring metabolic health. nature.com/articles/s41591-0…

Type 2 diabetes prevention across the life course

Nature Medicine - Rather than intervening when dysglycemia is established, prevention efforts should focus on prediabetes remission and restoration of normoglycemia. Here the authors call for a new...

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The decades long quest for reprogramming islet cell phenotypes #diabetes continues here using a metabolic pathway approach nature.com/articles/s41589-0…

Metabolic reprogramming drives pancreatic β cell neogenesis from α cells

Nature Chemical Biology - A chemical screen identified a PRC2–AR–ETV1–PPP axis that regulates β cell identity features in α cells. An intermediate PPP metabolite, methyl...

nature.com
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Daniel J Drucker retweeted
Eric Topol
@EricTopolAug 4
The GLP-1 drugs have evidence for beneficial impact— heart, kidney, liver, joints, immune system, and brain—that are independent of weight loss @Cell_Metabolism @DanielJDrucker cell.com/cell-metabolism/abs…
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How does GLP-1 work? Gustav Hållén the producer of Zero Order has figured it out. Have a listen youtube.com/watch?v=VCIWc2TX…

Zero Order - Food Noise (GLP-1)

A pharmacology banger about GLP-1, appetite regulation, dose-respon...

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