Interested in stuff. (This is my personal account only)
Ireland
Joined March 2014
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If you have time, watch this All In Podcast
Deeply concerning.
youtu.be/TBLHdXABwAg?si=x909…
Andrew Sharp retweeted
In this #3D TEE mid-esophageal RV in-out view you can better understand the location of different types of VSD in echo #echofirst supracristal VSD lying more cranial than the infracristal.
👉 for more morphological details check this out
doi.org/10.1016/j.athoracsur…
Using the International Society for Nomenclature of Pediatric & #CHD, the type of interventricular communication shown in the images, is an #outlet_muscular_VSD wo malalignment (4.a.i-07.11.06)
#cardioped #pedsheart
Andrew Sharp retweeted
Holy shit, America is cooked. They were able to perfectly clone the Microsoft Teams experience.
The European Commission has rolled out an alternative to Microsoft Teams.
But officials using it aren't impressed, with one describing the tool as “absolute shit.”
vist.ly/5kje9
Andrew Sharp retweeted
Dr Charles Ross announcing the @PERTConsortium Handbook of Pulmonary Embolism arriving in hardcover in January 2027! An amazing accomplishment led by a visionary in the field! #PERT2026
Andrew Sharp retweeted
“If someone would have told me years ago that we would have 3 positive RCTs for endovascular treatment of PE within 12-18 months, I wouldn’t have believed you. We are in the golden age of advanced therapies for PE” -Dr Robert Lookstein, MD
The largest rocket to ever travel around the world launched today, and then landed in the middle of the ocean next to the camera placed to record it.
It launched 26 satellites as a test.
There is a country, a major space power, that has only ever launched 98 satellites in its entire history.
Andrew Sharp retweeted
1/2 Our updated meta-analysis of intravascular imaging guidance publ in JACC. Since our last synthesis in Lancet 2024, there have been 6 new RCTs with 8,670 additional pts. Total is now 28 RCTs with 24,634 patients with mean FU 22 mos. Should be enough for a definitive answer!
Some things are less surprising than others.
Disappointing for patients, but perhaps not surprising.
Many thanks to those who set out to test plausible hypotheses.
Andrew Sharp retweeted
👉Just published in @NEJM: STAREE Trial
☝️At last, robust randomized evidence on statins for primary prevention in older adults.
🔹 9,971 adults ≥70 years, without cardiovascular disease, diabetes, or dementia
🔹 Atorvastatin 40 mg vs placebo
🔹 Median follow-up: 5.9 years
🔹 Baseline LDL-C: ~127 mg/dL NEJMoa2607314.pdf
👉Key findings:
🔹 30% reduction in major cardiovascular events
HR 0.70 (95% CI 0.61–0.82; P<0.001)
🔹 NNT = 37 over 5.9 years
🔹 MI: HR 0.57
🔹 Coronary revascularization: HR 0.57
🔹 Benefit was also observed in participants ≥75 years
👉Importantly:
🔹 No increase in dementia (HR 1.03)
🔹 No significant effect on all-cause mortality
🔹 No improvement in overall disability-free survival
🔹 Serious adverse events were similar between groups.
☝️Bottom line:
Age alone should not be a reason to withhold LDL-C lowering. Even in healthy adults ≥70 years, lowering LDL-C translates into substantial cardiovascular benefit.
@society_eas
@nationallipid
🔗nejm.org/doi/full/10.1056/NE…
Andrew Sharp retweeted
🫀 #REACT at #ESCCongress #Hotline
How early does atherosclerosis really begin?
16,808 adults, age 18–70 without known ASCVD underwent coronary, carotid & femoral imaging
🔎 Silent atherosclerosis: 57.1% overall
➡️ Already present in ~1 in 13 adults aged 18–29
➡️ ~9 in 10 by age 60–70!
💃🏻Women: steep rise during midlife, around menopausal transition; men developed atherosclerosis ~5–10 years earlier
🫀Atherosclerosis begins decades before clinical events—and often before conventional risk scores identify high risk. REACT should make us think about prevention much earlier
Next question: can imaging-guided early intervention actually prevent progression and events? Or should we just work to prevent CVD in everyone?
📄 @NEJM
nejm.org/doi/full/10.1056/NE…
#ASCVD #Prevention #WomensHeartHealth #CVPrev
Andrew Sharp retweeted
This is an incredibly important study.
The just presented SINGLE-AF trial randomised patients with a single risk factor (other than sex), demonstrating a significant reduction in stroke, systemic embolism, major bleeding, or death from cardiovascular causes at 24 months.
Although the @SCC_CCS AF guidelines (onlinecjc.ca/article/S0828-2…) have advocated for OAC for this group of patients for many years, sometimes at contrast with other national societies, its nice to see that this approach has been validated in a large RCT.
nejm.org/doi/full/10.1056/NE…
Andrew Sharp retweeted
In 10,000 asymptomatic women and men, the presence of obstructive subclinical coronary atherosclerosis conferred a 4-fold and 12-fold risk of myocardial infarction. Eur Heart J by AF Larsen, KF Kofoed et al in Copenhagen General Population Study:
academic.oup.com/eurheartj/a…
