@eagerbo

Statistician – professor at Aarhus University

Joined January 2010
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🙌 And to @NCRRCBP, Marianne Pedersen, @sussieantonsen, Emil Pedersen, @HorsdalThisted, Jean-Christophe Debost, @BoPreben, Liselotte Petersen, @bvilhjal, Jørgen Feldbæk Nielsen, Jeppe Klok Due, Anders Søgaard, @christian_igel, Wes Thompson, Chun Fan, @WrayNaomi, @John_J_McGrath
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📊 Interactive results: ncrr.au.dk/family_history
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Using Danish data on >3M people, we estimate absolute and relative risks, heritability & non-familial cases
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🙏 Thanks to @novonordiskfond
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Highly heritable: 45% (depression) to 77% (cannabis use disorder)
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💡Why it matters: • Family history alone can’t identify most cases • We need both population-level and personalized strategies
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🔗“Absolute and relative risks of mental disorders in families: a Danish register-based study” 👉 thelancet.com/journals/lanps… 📌Key findings: • Mental disorders are highly heritable – but most cases have no family history

Absolute and relative risks of mental disorders in families: a Danish register-based study

Individuals with family members with a mental disorder face increased risks of the same disorder. From a population perspective, most mental disorders occur in individuals without affected close...

thelancet.com
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People with affected 1st/2nd-degree relatives have higher risk • Yet most cases are non-familial:  ▫ 89% schizophrenia  ▫ 60% depression  ▫ 96% schizoaffective
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5 hurtige tips til ansøgninger om Sundhedsdatavidenskabelige (SDV) projekter hos #NVK Læs mere på nationaltcenterforetik.dk/an… #dkforsk
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The Danish Civil Registration System versus the lite Danish Multi-Generation Register. New paper by @NCRRCBP and folks
Carsten B Pedersen@NCRRCBP10 Apr 2023
1/n Familial aggregation studies of diseases rely on familial information linked with health records. We investigated the completeness of familial links in the Danish Civil Registration System and described the future Danish Multi-Generation Register doi.org/10.1177/140349482211…

Towards more comprehensive nationwide familial aggregation studies in Denmark: The Danish Civil...

Aim: Linking information on family members in the Danish Civil Registration System (CRS) with information in Danish national registers provides unique possibili...

journals.sagepub.com
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Congratulations, Emil – beautiful presentation, impressive work! @EmilP94637497 did an excellent job defending his PhD entitled: ”Leveraging family history and age-of-onset to boost GWAS power and disorder prediction”. Great discussion by the opponents @zkutalik, @michelnivard
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And congratulations to the proud supervisors @bvilhjal and @privefl
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Intriguing new statistical approach to distinguish between polygenic, de novo and Mendelian tail architecture via sibling gwas data
Tade Souaiaia@tadesouaiaia21 Feb 2023
Landmark new genetics manuscript just dropped. biorxiv.org/content/10.1101/…

Sibling Similarity Can Reveal Key Insights Into Genetic Architecture

The use of siblings to infer the factors influencing complex traits has been a cornerstone of quantitative genetics. Here we utilise siblings for a novel application: the identification of genetic...

biorxiv.org
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GWAS of ADHD by @DemontisDitte, @AndersBorglum and team identified 27 genome-wide significant loci, show that 84–98% of ADHD-influencing variants are shared with other psychiatric disorders, and much more. nature.com/articles/s41588-0…

Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate...

Nature Genetics - Genome-wide analyses identify 27 loci associated with attention-deficit hyperactivity disorder and provide insights into its genetic architecture in relation to other psychiatric...

nature.com
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Great to see this splendid, interesting and rich paper by tweetorial virtuoso @doctorveera. Well worth a read!
Veera Rajagopal 
@doctorveera10 Jan 2023
Better late than never. Happy and relieved to share a final published version of one of my PhD projects in which we uncovered a fascinating genetic link between language ability, psychiatric risk and creativity. 🧵 nature.com/articles/s41598-0…

Genome-wide association study of school grades identifies genetic overlap between language ability,...

Scientific Reports - Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity

nature.com
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Who’s ready for an exposé of statistical reviews over Christmas? Sneak preview of our stocking filler coming out in a few days in BMJ …
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Individuals with mental disorders lose 10·5 years of working life. Those with schizophrenia, mood, neurotic, eating disorders lose 18.9, 10.3 and 6.7 yrs
This Post is from a suspended account. Learn more
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Rough swimming today
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We would like to share with you our recently published article “Identification of shared and differentiating genetic risk for autism spectrum disorder, attention deficit hyperactivity disorder, and case subgroups.” rdcu.be/cWmMA… Details below.
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