Edgar Gonzalez-Kozlova (@EdgarEGK) header
Edgar Gonzalez-Kozlova (@EdgarEGK) profile picture

Computational Biologist. I use computers and stats to help answer difficult biological questions. Assistant Professor at @IcahnMountSinai

Manhattan, NY
Joined August 2013
Photo by Edgar Gonzalez-Kozlova (@EdgarEGK)Photo by Edgar Gonzalez-Kozlova (@EdgarEGK)Photo by Edgar Gonzalez-Kozlova (@EdgarEGK)Photo by Edgar Gonzalez-Kozlova (@EdgarEGK)Photo by Edgar Gonzalez-Kozlova (@EdgarEGK)Photo by Edgar Gonzalez-Kozlova (@EdgarEGK)Photo by Edgar Gonzalez-Kozlova (@EdgarEGK)Photo by Edgar Gonzalez-Kozlova (@EdgarEGK)Photo by Edgar Gonzalez-Kozlova (@EdgarEGK)Photo by Edgar Gonzalez-Kozlova (@EdgarEGK)
Another beautiful study from our research team composed of several laboratories spanning pathology, neuropsychiatry and immunology. nature.com/articles/s41467-0… @NatureComms @IcahnMountSinai
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When you are debugging with Claude code
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How To Choose a Good Scientific Problem cell.com/molecular-cell/full… via @UriAlonWeizmann
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It's f*cking wild: Google, Cloudflare, Obsidian's CEO and the guy building Claude Code all put their AI configs on GitHub for free, and most people are still starting from zero 1. Matt Pocock's skills · 318K stars 18M+ installs. the exact folder of AI instructions he uses every day: tests first, clear specs, real reviews github.com/mattpocock/skills 2. Addy Osmani's skills · 92K stars engineering skills from the guy working on Claude Code at Anthropic github.com/addyosmani/agent-… 3. Cloudflare's audit · 63.9K stars the starting point of what now scans 128 of Cloudflare's own repos. one team of agents hunts for bugs, another tries to prove them wrong github.com/cloudflare/securi… 4. Obsidian CEO's skills · 51K stars teaches any AI to write real Obsidian notes instead of messy text github.com/kepano/obsidian-s… 5. Google's goldfish · 14.8K stars 2 weeks old. the plugin Google's own engineers use to catch AI coding mistakes. the agent writes a design doc, then fresh AI sessions that never saw it try to tear it apart github.com/google/elephant-g… the biggest teams in tech already stopped writing prompts from zero. their configs are one click away save it and steal one tonight
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1. Have pedestrian idea. 2. Don’t publish a paper in several years. 3. Submit an R01 on a fantasy. 4. Get R01. Our review system needs an overhaul.
Step 1: have interesting idea. Step 2: publish idea in Immunity. Step 3: submit R01 building on idea. Step 4: Not Discussed. 🤦‍♂️🤷‍♂️😂.
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OUT NOW! NEW RESEARCH from @icahnmountsinai’s @DierdorffLauren, @DeRubeisLab, et al. reveals motor deficits in #DDX3XSyndrome depend on specific brain circuit linking cortex to the brainstem & early intervention can improve motor trajectories! @PNASNews 👉 pnas.org/doi/10.1073/pnas.25…
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Seeing a potential benefit of high blood sugar is unusual, to say the least. High blood glucose improved T cell (CD8+) function to take on cancer, in experimental models and in vitro with human cells, with a mechanistic explanation academic.oup.com/jimmunol/ar…
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I am super excited to see this R01 second percentile score! I know this isn't a notice of award, but to be within weeks of officially starting my lab, this feels huge. Thrilled to see where we can go with this. @StanfordDeptMed @StanfordCVI weldylab.org
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I love papers where researchers do this kind of meticulous but "boring" work that benefits the whole field. About 1 in 3 gene-trait links from transcriptome-wide associations studies (TWAS) give false signs of association. TWAS is a popular method that aims to predict the influence of DNA variants on gene expression activity. The authors cleverly used people who carry broken or duplicated copies of a gene, where the true direction can be inferred. doi.org/10.1038/s41588-026-0…
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Since in science, it’s important to also highlight the failures
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See the Full Study in Nature Communications 👉 nature.com/articles/s41467-0… SECmeres outperform extracellular vesicles as potential blood RNA biomarkers for Alzheimer’s disease - @EdgarEGK, Swapnil Tichkule, Yohei Nose, John Fullard, @panos_roussos @dogranavneet, et al.
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We look forward to hearing from Anirban Maitra, MD, on November 10: Mediators of Restraint in Early Pancreatic Neoplasia. @Aiims1742 @nyulangone Hosted by @Poulikos @IcahnMountSinai
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🧠 Call for Papers | EVCNA Explore #EV-Mediated #Communication in the #Gut–#Liver–#Brain Axis with Guest Editor Dr. Vicente Felipo! Topics include #neuroinflammation, #microbiota-derived #EVs, disease #biomarkers, and #neurological dysfunction. 🔗 oaepublish.com/specials/evcn…
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I recently spoke with @PsychTimes about our work on #RNA #biomarkers for Alzheimer’s disease and the potential of #Exosomes #ExtracellularVesicles and Particles in this field. Link to the Interview: youtu.be/gmQ4vTHeL1g?si=ia_e…
Psychiatric diseases lack precision diagnostics & blood-based biomarkers. Definitive diagnosis of #Alzheimers remains postmortem. In an interview w/ @PsychTimes, Dr. @dogranavneet shared his research on earlier biomarker testing for #Dementia. Watch Here👉 youtube.com/watch?v=gmQ4vTHe…
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Another pan-cancer/tumor agnostic target. Claudin 18.2; 🎯🎯lots of nausea/vomiting though 🤢
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Replying to @UGrewalMD
I’m truly sorry you experienced this, and I hope it gets rectified. Perhaps publishers should start paying reviewers. How do they make so much money while academics review manuscripts for free? No wonder some might turn to AI just to get through reviews faster!
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🌿 Can plant-derived extracellular vesicles unlock new insights into gut–liver communication? Our latest Review explores their potential as natural nucleic acid carriers in metabolic liver disease—and the evidence gaps that remain. 📖 Read more: oaepublish.com/articles/evcn…
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📢 Meet EVCNA at APSEV 2026 / JSEV 2026! 📍 Tokyo, Japan | 📅 Oct 22–23, 2026 | Booth #22 EVCNA warmly invites you to visit our booth! Meet our editorial team, explore publishing opportunities, and exchange ideas on the latest advances in EV research. See you there! 🤝
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BREAKING: Nobel laureate David Baker’s team just published TWO Nature papers in one day! AI-designed proteases from scratch: 🧬 Cysteine proteases: 19% success rate, functional in mammalian cells. 🧬 Metalloproteases: 36% success rate, with over 10 BILLION-fold catalytic acceleration vs. the uncatalyzed reaction. From predicting protein structures to designing catalytic function. 📄 Nature papers: nature.com/articles/s41586-0… nature.com/articles/s41586-0…
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Great to have Tyler Jacks @kochinstitute at @CDI_Einstein @EinsteinMed yesterday! A trailblazing scientist & amazing communicator, now leading the charge on large-scale clinical insight through @break_cancer
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