@hscrb/@broadinstitute postdoc with @jd_buenrostro looking at chromatin and signaling. previously: PhD @princetonmolbio with @toettch
somewhere in the nucleus
Joined November 2011
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Excited to share my postdoc work, out on bioRxiv today! Histones package DNA into nucleosomes to form the building blocks of chromatin, but how modular and programmable is this system? 1/9
siddhartha jena retweeted
🚨New paper alert!🚨 Cells integrate signals into decision-making. But how do levels of signaling influence cell-fate transitions? Is more always better? Or is there an “optimal” level for cell-fate programming? If we could tune signaling, could optimize production of neurons? Read on! (1/n)🧵
Huge thanks to all co-authors and the inimitable
@JD_Buenrostro for supporting this new direction - I got to think about evolution, engineering, chromatin biophysics, and modeling during the course of this project. For more, check out the preprint: biorxiv.org/content/10.1101/…
siddhartha jena retweeted
My NIH Study Section (MABS) was cancelled a little more than 24 hours before the start. With 35 members, & 45 h of reviews/member, that wasted 1575 hours of scientists' unpaid time. @NIH, protect scientists right now & cancel all study sections until you get clarity. @NIHDirector
Doing big things @maxzwilson!
MolBio grad and postdoc alum, Max Wilson *15, currently Asst Prof at UCSB's Dept of Molecular, Cellular & Developmental Biology is Co-founder of Integrated Biosciences and for his first sabbatical will work as Chief Scientific Officer of the 2022 startup. integratedbiosciences.com/ne…
ALT The Integrated Biosciences startup team: (l-r) Satotaka Omori, Head of Aging Biology; Alicia Li, Research Associate; Max Wilson *15, Co-founder; Felix Wong, Co-founder; and Ryan Lach, Head of Bioengineering.
Great work and some really beautiful imaging data @h4rrymcnamara , @toettch and team!
Our study decoding gastruloid symmetry breaking is now live @NatureCellBio!
rdcu.be/dVMLG
Thank you to the NCB edititorial team and to our reviewers for a constructive review process which helped improve our study. A thread on updates (1/n):
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Really superb work from my awesome labmates! It's been awesome watching this project develop over the years.
7 years ago, I met a junior fellow named @JD_Buenrostro who blew me away with a vision of futuristic genomic technologies
Today, we (@ajaylabade31, @carolinecomenho) are excited to share our first steps into that future: Expansion in situ genome sequencing
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siddhartha jena retweeted
Levels of gene expression matter! So how can you control a transgene precisely? Is there a tool that can ensure uniform control & the ability to adjust the setpoint of expression from a single promoter? Introducing DIAL! 🧵 (1/n)
Link: doi.org/10.1101/2024.06.19.5…
siddhartha jena retweeted
T cells become exhausted and fail to control tumors in cancer patients. What if we could replicate T cell exhaustion in vitro and uncover the gene regulatory network driving exhaustion, enabling immuno-oncology drug discovery? With AstraZeneca, the Buenrostro lab addresses this gap (biorxiv.org/content/10.1101/…):
siddhartha jena retweeted
Congrats Yusuke! Glad to finally see the fruits of your efforts over the years.
nature.com/articles/s41588-0…
siddhartha jena retweeted
We are recruiting postdoctoral fellows in neurobiology and development to complement our group specializing in genomic technologies, epigenetics and machine learning. projects are very well funded and we are interested in co-mentorship. Please DM if interested in hearing more!