Clinical Senior Lecturer @Kings College London. Medical Oncologist @Guy’s and St Thomas’ NHS Trust. Brain mets researcher. @WSETglobal Level 3 certified
London, UK
Joined December 2020
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Amanda Fitzpatrick retweeted
HER2+ mMBC in asymptomatic patients, proactive cranial screening:
→ Symptomatic brain metastases: 0% vs 9.5%
→ Brain metastases detected smaller and with better performance score
→ Reduced need for WBRT
aacrjournals.org/clincancerr…
Thought provoking talks on the booming field of #cancerneuroscience & the promising new treatment approaches using existing drugs to modulate neuronal mechanisms #EANO2024 @wick_wolfgang @humsav @Winkler_Lab
So good to see this data showing effectiveness of an ADC in patients with active brain metastasis - hope it paves the way for many more to come!
New article in press: A Pooled Analysis of Trastuzumab Deruxtecan in Patients With HER2-Positive Metastatic Breast Cancer With Brain Metastases. @FAndreMD @curijoey @Prof_Nadia_H
doi.org/10.1016/j.annonc.202…
Amanda Fitzpatrick retweeted
TBCRC 049: Tucatinib, trastuzumab, capecitabine for HER2+ LMD
-The first prospective LMD trial to show all of the following:
-therapeutic drug levels in CSF
-intracranial response
-improvement in symptoms and QoL
-extended OS compared to historical controls
This will be great - and in my hometown!
📣Have you heard? Abstract submission for #EANO2024 is now open and closes on April, 30! Don't miss the chance to present your work in #NeuroOncology. The 19th Meeting of the EANO will be held in Glasgow (UK), Oct 17-20, 2024. See you there! 👉eano.eu/eano2024/abstracts/ #btsm
Super excited by this new finding - could this also be a potential route for metastatic cells to invade the CNS?
I am excited to share our latest research on the arachnoid barrier, a crucial yet poorly understood structure that partitions the CNS and the dura, out today @Nature. We discovered that gaps in this barrier allow communication between the CNS and the dura. nature.com/articles/s41586-0…
Amanda Fitzpatrick retweeted
Some news coverage of our CAcTUS trial using ctdna to decide when to switch treatment -shows what it means for patients - although the data is very early and still to be understood properly!
bbc.co.uk/news/uk-england-ma…
Amanda Fitzpatrick retweeted
#ICYMI @CancerTodayMag wrote up the panel that @CareyAnders1 led at @SABCSSanAntonio last month! Check out the link to read about treatment options for #brain metastases in #BreastCancer.
cancertodaymag.org/cancer-ta…
Really important work from the @dr_yinwu lab @KingsCollegeLon, dissecting the role that γδ T cells play in determining response to immune checkpoint inhibitors. 👏 nature.com/articles/s43018-0…
Is metastatic spread to the leptomeninges simply the end process of a widely metastatic cancer, or does it have its own unique metastatic drivers and evolve early in the disease? Read all about it in my paper recently published nature.com/articles/s41467-0… @ICR_London @KingsCollegeLon
Hugely grateful to all involved academically in this work, patients, funders @The_MRC @BreastCancerNow @RMresearch_ @kingshealth and the clinical centres involved @GSTTnhs @royalmarsdenNHS
Excited to get started on this project developing liquid biopsy methods to more accurately define patients benefiting from immunotherapy - with Yin Wu @dr_yinwu @kingshealth @KingsCollegeLon
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Amanda Fitzpatrick retweeted
🌟NEW @NatureMedicine: interim results of the first trial evaluating concurrent intrathecal + IV anti-PD-1 in patients with #melanoma & #leptomeningealdisease Great work led by @GlitzaMDPhD #MichaelDavies @HTawbi_MD @MDAndersonNews #immunotherapy nature.com/articles/s41591-0…
Amanda Fitzpatrick retweeted
Our clinical leaders are very concerned about the potential harm to patients that may be caused by the upcoming junior doctors’ strike.
We are calling on the Government and unions to do everything in their power to suspend the strike.
bit.ly/StrikeImpact
1/5
ALT Photo of the exterior of St Thomas' Hospital
Such a pleasure to talk on management of leptomeningeal disease at #UKBCG today - biggest outcome is that there’s now enough data in this field to fill 20min slot! #breastcancer #brain
Great PhD opportunity unravelling the drivers of lung cancer progression using #liquidbiopsy colcc.ac.uk/2023-phd-project…
Best of all, the supervisors! @MariamJHanjani @CharlesSwanton @fitzpat_a @CRUKCOLcentre
Delighted to have our poster picked as a winner! Thanks to all the team who worked on this together, esp Alex Bartram and Louise Rockall 🙌🙌@BrainBarts @barts_team.
Congratulations to Amanda Fitzpatrick @fitzpat_a for winning Best Clinical Poster in BNOS 2022!
#BNOS2022 @BNOSofficial @NHSBartsHealth @BartsHospital
Amanda Fitzpatrick retweeted
Barts Neuro-Oncology Team present our work, as one of the largest stereotactic radiotherapy centres in the UK, at the British Neuro-oncology society 2022 in Liverpool.
#BNOS2022 @BNOSofficial @NHSBartsHealth @BartsHospital
Wonderful to be in-person at a conference finally @ #eacrLiquidBiopsies in the stunning city of Bergamo. Morning kicked off by great talk from @haichao_wang20 on new #ctDNA fragmentomics tool
