We use Drosophila to study mitochondria @uoft
Toronto, Ontario
Joined January 2019
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We are excited to share this new story from our lab! We report discovering a crucial piece of the long-standing mystery of how mitochondrial (mt) genomic integrity is maintained across generations. Summary follows: 🧵 1/9 tinyurl.com/y3dz9ca5
Our work suggests the exciting idea that mtDNA selection and meiosis, which are required for maintaining mtDNA and nuclear DNA fitness respectively, are genetically and developmentally linked. 8/9
This work was a great effort by many in the lab, especially @jonathanpalozzi, Swathi Jeedigunta and Anastasia Minenkova, and we thank so many others in Toronto and elsewhere who have heard the story and provided great insight and suggestions! 9/9
Thanks to everyone for a successful #CanFly2019, especially the organizing committee: Julie Brill, Bruce Reed, @RFG_Lab, @tjsmerritt, @kramer_lab, @KimlabFlyroom, @IanDworkin, as well as all the PIs and trainees who shared their great science this past week!
this cool fly art is courtesy our neighbour Janine in Craig Smibert’s lab. You can find more of them @drosophiladiez on Instagram!
You can learn about one of the current projects in the lab, mtDNA purifying selection, in this review we published recently:
sciencedirect.com/science/ar…