post-doc @AlexandervanOu1 | PhD @MedemaRene | Utrecht | single cell sequencing | DNA replication | CRISPR | Genomic instability & Cell Fate | he/him
Utrecht, Nederland
Joined April 2010
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Exhilarated to share our pre-print describing a novel method, scEdU-seq, to measure DNA replication forks and their speeds in singe cells. Many thanks to @AlexandervanOu1, @Bvincentv and others @_Hubrecht for making it happen!
biorxiv.org/content/10.1101/… – at Utrecht, The Netherlands
Happy to share this concise review and outlook for single-cell sequencing methods to unravel cell biology of the nucleus! Big shoutout to my friend and former colleague Peter Zeller for sharing the work!
sciencedirect.com/science/ar…
Do not miss out on this webinar on
@bioprotocolbyte to see what we have been up to in quantifiying single cell DNA replication dynamics using scEdU-seq ! 🚀 Register now!
bio-protocol.org/webinar/det…
It was an absolute blast to write this @novonordiskfond grant together with my long-time friend @Lleonie and to now to have it funded for 2M EUR🤯. Many thanks to @AlexandervanOu1 and @groth_anja for their unwavering support and invaluable input! Exciting things to come 🎆🎆🎆
How reliably is the epigenome passed from one cell to its daughter cells? @AlexandervanOu1, @jervdberg, @groth_anja & @Lleonie received a @novonordiskfond grant to answer this question, which will lead to new strategies to prevent disease and combat aging hubrecht.eu/novo-nordisk-epi…
Jeroen van den Berg retweeted
Researchers from the Mattiroli group discovered that DNA packaging in cells can directly impact the speed of DNA copying during cell division. The packaging sends signals through an unusual pathway, affecting the cell’s ability to divide and grow. More: hubrecht.eu/dna-packaging-di…
Great to see this work finally out in the open! It was a lot of fun to collaborate with the lab of @FMattiroli
Online Now: Acute multi-level response to defective de novo chromatin assembly in S-phase dlvr.it/TG85ld
Jeroen van den Berg retweeted
Acute multi-level response to defective de novo chromatin assembly in S-phase (Dreyer et al., 2024) cell.com/molecular-cell/full…
Jeroen van den Berg retweeted
Very interesting findings by the CAF-1 degron system! Slow replication reminds me of early mouse embryos.
Acute multi-level response to defective de novo chromatin assembly in S-phase: Molecular Cell cell.com/molecular-cell/full…
Jeroen van den Berg retweeted
Happy to share latest work from the lab! nature.com/articles/s41467-0…
Jeroen van den Berg retweeted
Cost of having DNA methylation: DNA replication by DNA polymerase epsilon is a source of C to T mutations in CpGs, especially methylated ones. This expands our understanding of one of the most widespread endogenous mutational mechanisms. nature.com/articles/s41588-0…
Jeroen van den Berg retweeted
Job alert! Do you know a postdoc candidate that loves microscopy and wants to visualize how cells repair their DNA, please forward them this opportunity: lumc.nl/en/about-lumc/werken…
Jeroen van den Berg retweeted
I'm delighted to have received the award for best presentation at the 10th NECO. It was a fantastic experience with exceptional people. @CenGEM_Brunel @EviSoutoglou @Diana_Rubio_
Jeroen van den Berg retweeted
Excited to start this new endeavor! Thanks to @GrundforskFond for selecting our application for a center of excellence and to the Danish Cancer Institute for welcoming us @cancer_dk
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Great work @stefanogmanzo !! 🎉 Congrats to all the authors
So thrilled to see our work on regulation of transcriptional repression in lamina-associated published in @embojournal. Thanks to all the authors!! Thanks to all the authors for their fantastic contribution. embopress.org/doi/full/10.10…
Jeroen van den Berg retweeted
Did you know that DNA polymerase κ plays dual roles in translesion DNA synthesis?
@duxin_lab’s latest @NatureSMB article explores its catalytic and noncatalytic functions in bypassing DNA lesions.
Check it out here: rdcu.be/dUFTk
Kudos to the amazing team! 👏
Jeroen van den Berg retweeted
Outstanding science and high spirits at CSHL Epigenetics & Chromatin meeting #cshlepich24 @berger_lab @NogalesLab @AnneF_S @Yael_David__ @Goodell_Lab @AsifaAkhtar1 @GAlmouzni Narlikar, Luger, Jabado
Jeroen van den Berg retweeted
Now online! In vivo DNA replication dynamics unveil aging-dependent replication stress dlvr.it/TDMNkz
Jeroen van den Berg retweeted
I’m so thrilled to share my first first-author pre-print! 💪🎉🥳
This was an amazing collaborative work from @Tanejalab, @AguileRloop and @lugerlab!
How do #chromatinremodelers, #Rloops and mutations in #cancer correlate? A small 🧵below for you!
biorxiv.org/content/10.1101/…
Wow! Super humbling to see our method being presented at a meeting I could not visit! @AlexandervanOu1 @BVincentv! Thanks a lot @FMattiroli and @groth_anja 👏 🥳
🔬🥼 Highlighted techniques:
PTM occupancy on newly replicated DNA in chromatin (ChOR-seq) and sister chromatids (SCAR-seq)
scEdU-seq: Super cool (also new!) single-cell resolution for nascent replicated DNA @jervdberg @AlexandervanOu1 & team
nature.com/articles/s41592-0…
Jeroen van den Berg retweeted
Now Online Dynamics of DNA replication speeds in single cells dlvr.it/TCs74X
Jeroen van den Berg retweeted
Take a look at our latest Tools of the Trade article, written by @jervdberg on work done in the @AlexandervanOu1 lab! See the original paper @naturemethods: nature.com/articles/s41592-0…
Extremely honored to be invited to write about scEdU-seq as Tools of the Trade article in @NatRevMCB . Many thanks to @lisa_heinke for the invitation and opportunity! 🎉rdcu.be/dS3WR