👨💻 Passionate Web & App Developer — ✨ AI Enthusiast — 🐘 https://nitter.gq/t.co/AUFEetxuhq — 🦋 https://nitter.gq/t.co/BCxPkRruFA
Hattem, Nederland
Joined April 2008
- Tweets26K
- Following616
- Followers573
- Likes2.5K
Wow 🤯
We asked GPT-6 Astra to edit Qwen3.5-0.8B weights to improve math.
It directly changed only 0.016% of weights, fixing 0.8B's reasoning loops & improving math up to 6x and even instruction following 3x, without gradients or training.
We call this Weight-Space Programming: frontier LLMs can now natively read/write neural network weights! 🧵
Blog: rikiyat.github.io/blog/weigh…
Jonathan retweeted
wtf
this guy just had Claude Sonnet 5 perform brain surgery on a living mouse
the goal was to treat the mouse's epilepsy so it would stop having so many seizures.
here's what Claude did:
> it looked at 19 possible treatments and picked one that boosts the brain's natural calming chemical
> it chose where to inject it based on where these seizures are thought to start
> it worked out the exact injection point by averaging three research papers
> it lowered the needle 4.3 millimeters into the mouse's brain
> it injected a 20,000th of a teaspoon of the treatment over five minutes
> it checked the live camera 32 times to watch for things like bleeding
and the mouse woke up and recovered well!
interestingly, Opus 5.5 and Opus 5 both refused the task because it involved real biology
so Sonnet 5 got the job.
and as far as the researcher knows it's the first time an AI has picked a treatment and then injected it into the brain of a living mammal.
Last night an AI agent performed brain surgery on a mouse.
We gave it 19 gene therapy vectors in a spreadsheet, a mouse model of epilepsy, access to a motorize surgery rig with cameras and one goal: reduce seizures.
It picked the drug. It picked the brain region. It derived the coordinates from three papers. Then it drove the stereotaxic arms into the brain and injected 250 nanolitres while watching the entry site through the rig camera for bleeding.
A licensed vet gated every irreversible step and held a physical kill switch to stop the AI agent.
Thread on what it decided, what it saw, and the moment it refused to let me override it.
[Writing this on the spot out of excitement, but I've been 18hrs in front of my laptop coding and coordinating this, so keeping it brief and descriptive, more cohesive thoughts on this soon...]
One observation about iPhone Duo to point out separately: the new navigation paradigms make me feel lost.
I’m afraid this isn’t a matter of getting used to new things. Some fundamentals have been taken away.
Related: modals aren’t easily recognizable. They used to be inset from the top, visually overlapping the previous screen. Now they have a small border/inset all around, which is hard to recognize. Again, you can’t glance to see where you are.
I’ve had the iPhone Duo for over 24 hours now. It’s an interesting device! Finally something new and different. Will post some observations in this thread.
Holding it in one hand is challenging. Coming from an iPhone 13 mini, this is the biggest step back. My pinky finger already hurt after just a few hours of use yesterday. This is my biggest doubt about whether I want to keep the Duo.
For people with the iPhone Duo simulator: when closed, can we use a smaller keyboard aligned to the left or right, like on Plus/Max iPhones? How does it look?
Jonathan retweeted
Mijn inzending voor de ontwerpwedstrijd van NS voor een nieuwe spoorkaart van Nederland!
De uitdaging was om alle 400 stations en tientallen lijnen van verschillende vervoerders overzichtelijk op te nemen.
Een paar ontwerpkeuzes hieronder:
Waarom laat Google Shopping de “populairste” in plaats van “beste” (laagste) prijs onder een product zien? 🤯
google.com/search?q=Liebherr…
En waarom is bij dit product de “beste” prijs niet het laagst? 🤯🤯
google.com/search?q=Liebherr…
