In the RSI trial involving critically ill patients undergoing intubation in EDs or ICUs, the use of ketamine for the induction of anesthesia did not lead to significantly lower in-hospital mortality than etomidate. Full trial results and Research Summary: nejm.org/doi/full/10.1056/NE…

The causes of cardiogenic shock can be divided into groups on the basis of etiologic factors: acute myocardial infarction; factors not related to myocardial infarction, such as new or acute-on-chronic heart failure; or secondary nonmyocardial causes and postcardiotomy shock (seen in first image). For decades, ventricular failure after acute myocardial infarction was the most frequent cause of cardiogenic shock, with mechanical complications related to the infarction representing a rarer cause. Because treatment strategies for acute myocardial infarction have advanced with improved prevention and early revascularization, the relative proportion of cardiogenic shock events attributable to myocardial infarction is steadily declining, and non–infarction-related cardiogenic shock now outnumbers infarct-related cardiogenic shock (seen in second image). Learn more in the Review Article “Cardiogenic Shock” by Holger Thiele, MD (@thiele_holger), and Christian Hassager, MD, from Heart Center Leipzig at Leipzig University, Leipzig Heart Science, Rigshospitalet, and the University of Copenhagen (@koebenhavns_uni): nej.md/49ohKyV