aquifer (@jppathpd) profile picture

aquifer

@jppathpd

Pathologist #PathKeys

 Posts = my own opinion
Joined November 2022
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101Media
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Dx? salivary gland S-100 #Pathkeys
Image from aquifer (@jppathpd)
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猸昐ecretory carcinoma 馃敩Microcystic and glandular growth with eosinophilic secretions; apocrine-like cells with vacuolated cytoplasm and vesicular nuclei 馃ИS100+, mammaglobin+; AR-, p63- 馃КETV6::NTRK3 fusion, t(12;15)(p13;q25). Low-grade; recurs in about 30%
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Image (pathology): Suzuki K, et al. BMC Med Genomics 2022;15:6 (CC BY 4.0) Ref: Suzuki K, et al. BMC Med Genomics 2022;15:6 Rosai and Ackermann's Surgical Pathology
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Dx? thorax #Pathkeys
Image from aquifer (@jppathpd)
Image from aquifer (@jppathpd)
Image from aquifer (@jppathpd)
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馃КSMARCA4 inactivation (SWI/SNF). This case: TP53 p.V274A, TMB 12.6 鈽笍Right pleural-based masses and plaques with effusion on CT; FDG-avid on PET/CT (SUVmax 14.3)
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Image (pathology, CT, PET/CT): Hanona PF, et al. Thorac Cancer 2024;15:847-851 (CC BY 4.0) Ref: Hanona PF, et al. Thorac Cancer 2024;15:847-851 Yu X, et al. Front Oncol 2026;16:1813580
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Dx? breast HER2 #Pathkeys
Image from aquifer (@jppathpd)
Image from aquifer (@jppathpd)
Image from aquifer (@jppathpd)
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馃КHER2 overexpression in up to ~90% of cases 鈽笍MRI: enhancement and thickening of the nipple-areolar complex, with retroareolar or segmental non-mass enhancement.
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Image (pathology): Sharma A, et al. Cureus 2026;18:e110432 (CC BY 4.0) Image (MRI): Mariano L, et al. Front Oncol 2025;14:1497506 (CC BY 4.0) Ref: Choridah L, et al. J Med Case Rep 2020;14:119 Ref: Cantisani C, et al. Diagnostics 2025;15:1898
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Dx? soft tissue HE #Pathkeys 2025-1p-5 (etc)
Image from aquifer (@jppathpd)
Image from aquifer (@jppathpd)
Image from aquifer (@jppathpd)
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馃Кt(X;18) SS18::SSX1/2/4 fusion 鈽笍Well-circumscribed intramuscular mass with heterogeneous enhancement on contrast-enhanced MRI (representative case)
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Image (pathology, MRI): Choi JH. Int J Mol Sci 2026;27:4125 (CC BY 4.0) Ref: Choi JH. Int J Mol Sci 2026;27:4125
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Dx? breast ER #Pathkeys 2013-2a-11
Image from aquifer (@jppathpd)
Image from aquifer (@jppathpd)
Image from aquifer (@jppathpd)
Image from aquifer (@jppathpd)
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鈽笍Round high-density mass on mammography; circumscribed hypoechoic mass with blood flow on US (this case)
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Image (pathology, US): Lin X, et al. Surg Case Rep 2020;6:143 (CC BY 4.0) Ref: Lin X, et al. Surg Case Rep 2020;6:143 Chiang S, et al. Cancer Res 2016;76:7118-7129
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Dx? thyroid HE #Pathkeys 2025-2a-15 (etc)
Image from aquifer (@jppathpd)
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猸昅edullary thyroid carcinoma 馃敩Nests of monotonous polygonal to plasmacytoid cells in a hyalinized stroma 馃КRET or RAS driver mutations, mutually exclusive in sporadic cases; germline RET in MEN2A/2B
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Image (pathology): Rossi ED, et al. Virchows Arch 2026;489:427-439 (CC BY 4.0) Ref: Rossi ED, et al. Virchows Arch 2026;489:427-439
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