@kchev

software engineer @arcadiascience, runner, cyclist, conifer aficionado.

 Berkeley, CA
kchev.io
Joined March 2009
  • Tweets237
  • Following175
  • Followers95
12Media
Interested in computationally exploring how proteins are related across species? Join us @ArcadiaScience and engage collaboratively to design, create, and iterate on workflows and tools for comparing proteins in diverse organisms. Check out the job ad ➡️jobs.lever.co/arcadiascience…
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Just launched v0.2.0 of our cell tracking tool 🚀 Check out our GitHub repo: github.com/royerlab/ultrack! Seamlessly combines segmentation & tracking via Python API 🐍 Scales effortlessly to handle massive datasets, like the #zebrahub paper. #CellTracking #Bioinformatics
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📢 Very excited to see our work #cytoself now published in @naturemethods . #cytoself is a deep learning method for fully self-supervised protein localization profiling and clustering. Led by @liilii_tweet with @kchev @LeonettiManuel at @czbiohub nature.com/articles/s41592-0… 1/n
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Check out our latest paper on self-supervised ML!!! w/ @loicaroyer @liilii_tweet @kchev, built upon OpenCell data. Loic’s tweetorial has all the info 👇
Loïc A. Royer 💻🔬⚗️@loicaroyer25 Jul 2022
📢 Very excited to see our work #cytoself now published in @naturemethods . #cytoself is a deep learning method for fully self-supervised protein localization profiling and clustering. Led by @liilii_tweet with @kchev @LeonettiManuel at @czbiohub nature.com/articles/s41592-0… 1/n
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#OpenCell is mapping our cells one protein at a time and paving a new way to visualize cellular architecture through a free, open-source website. Explore it now: opencell.czbiohub.org/ youtube.com/watch?v=6j4fpV-q…
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Published today in Science, a team from CZ Biohub and @MPI_Biochem combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. 🧵 science.org/doi/10.1126/scie…

OpenCell: Endogenous tagging for the cartography of human cellular organization

Combining genome engineering, live-cell imaging, mass spectrometry, and data science are used to map the localization and interactions of human proteins.

science.org
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COVID Update: One too many smart people has told me or said on TV this week that the pandemic is over. I offer this thread as a single, uniform response to everyone. 1/
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I am seeking an Associate R&D Engineer for our amazing BioE team at @czbiohub. We work on a wide range of important problems related to human health spanning from basic cell biology, infectious disease research, low-cost diagnostics, and outreach in underserved communities.
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📢 Job alert (please RT): my lab is looking for a PhD-level scientist to join us @czbiohub. We study virus-host interactions across different viral families using a combination of CRISPR/base editing screens, molecular virology and cell bio methods. apply.workable.com/j/97E9644…
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Covid (@UCSF) Chronicles, Day 504 To me, the most confusing time in the pandemic was May 2020, as we exited lockdown and nobody quite knew what they should & shouldn’t do (clean the mail? touch the dog?). But now is giving May 2020 a run for its money. (🧵1/25)
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We should worry about the future "worse" variants that will likely result from uncontrolled spread. But they are not likely to "escape vaccine-induced immunity." There are several reasons why this is the case.
Dr. Tom Frieden
@DrTomFrieden26 Jul 2021
Replying to @DrTomFrieden
1) The emergence of future variants that can escape vaccine-induced immunity. Delta may not be the worst variant the virus deals us. Continued uncontrolled spread around the world makes this scenario more likely.
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#imaging #deeplearning job alert! Come work with me + @loicaroyer in SF to develop new methods for phenotypic screening w/ fluorescence imaging. Building upon opencell.czbiohub.org and our new self-supervised cytoself DL to encode protein localization apply.workable.com/czbiohub/…
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📢 Job alert, plz RT! Join @czbiohub for exciting research at interface of cell biology, engineering, technology and medicine. Check out opencell.czbiohub.org/ Bioinf. Data Scientist apply.workable.com/czbiohub/… Scientist apply.workable.com/czbiohub/… Senior RA apply.workable.com/czbiohub/…
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Yesterday there was a flurry of scolding FDA & CDC, mainly from non-scientists/public health folks, about the J&J pause. But this was the right thing to do for many reasons. Transparency, informing clinicians & vaccinees, & investigating safety signals is how this should work.
Craig Spencer MD MPH
@Craig_A_Spencer14 Apr 2021
The many hot takes on here that the complications from J&J are so rare we shouldn’t have paused it’s use are persuasive at face value. The pandemic IS still raging. We NEED shots in arms. And the risk is SO low! This is all true. But that argument is missing something critical.
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Cellular life is amazingly complex. To find cures for diseases, we must understand the molecular details of how cells and their proteins operate. Visit our new OpenCell website and interactively explore the localization and interactions of human proteins:opencell.czbiohub.org
Manuel Leonetti@LeonettiManuel30 Mar 2021
Endogenous tagging + 3D live-cell imaging + mass-spec interactome = opencell.czbiohub.org, an open-source map of the human proteome. So excited for our first release, wonderful collaboration with @labs_mann @loicaroyer & many other colleagues. @OpenCellCZB
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Our first release is live! 🚀 A collaborative effort led by @LeonettiManuel with @labs_mann and @loicaroyer and many others at @czbiohub to build an open-source map of the human proteome. Check it out and let us know what you think! opencell.czbiohub.org
Manuel Leonetti@LeonettiManuel30 Mar 2021
Endogenous tagging + 3D live-cell imaging + mass-spec interactome = opencell.czbiohub.org, an open-source map of the human proteome. So excited for our first release, wonderful collaboration with @labs_mann @loicaroyer & many other colleagues. @OpenCellCZB
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Our first release is live! 🚀 A collaborative effort led by @LeonettiManuel with @labs_mann and @loicaroyer and many others at @czbiohub to build an open-source map of the human proteome. Check it out and let us know what you think! opencell.czbiohub.org
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Super excited to present cytoself — our deep learning method for fully self-supervised protein localisation profiling and clustering. Fantastic work by @liilii_tweet together with our @czbiohub colleagues @kchev and @LeonettiManuel. biorxiv.org/cgi/content/shor… 1/n
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Endogenous tagging + 3D live-cell imaging + mass-spec interactome = opencell.czbiohub.org, an open-source map of the human proteome. So excited for our first release, wonderful collaboration with @labs_mann @loicaroyer & many other colleagues. @OpenCellCZB
bioRxiv@biorxivpreprint30 Mar 2021
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization biorxiv.org/cgi/content/shor… #bioRxiv
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Probably not getting the attention it deserves: Visualizing with Text, by @rkbrath richardbrath.wordpress.com/b… See all the wonderful visuals here: richardbrath.files.wordpress…
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