Arnout Voet, Computational protein and drug design, structural biology, biomolecular modelling, protein crystallography and biophysics.
Leuven
Joined June 2020
- Tweets306
- Following408
- Followers719
- Likes616
Laboratory of biomolecular modelling and design retweeted
We are looking for a biocatalyst/protein engineer to establish high-throughput assays for our AI-designed enzymes. Join our mission in an excellent location/resources and drop me a message anytime if you'd like to know more :)!
tinyurl.com/5dhxphb6
Laboratory of biomolecular modelling and design retweeted
Short summary thread of our recent review on de novo protein design:
(Poster-sized figure (36 x 48 inches) for printing: drive.google.com/file/d/1sG3…)
Laboratory of biomolecular modelling and design retweeted
Prof @xinshi_d on his #ERCStG: "I'm very grateful that there are funding opportunities in the EU for curiosity-driven basic science. It’s a recognition of the importance to boldly try things that no one has before." @ERC_Research @kuleuven_fwet @KU_Leuven
set.kuleuven.be/en/news/inte…
Laboratory of biomolecular modelling and design retweeted
Another molecular glue at #EFMCISMC24: Novartis #NLRP3 inhibitor DFV890 stabilizing an inactive conformation. Also another example for a non-standard sulfur(VI)-functional group in a drug candidate. No, not a sulfoximine… @EuroMedChem
Laboratory of biomolecular modelling and design retweeted
I need to share Emma‘s inspirational final slide as well… Small Molecule Drug Discovery is making a difference for so many patients! #EFMCISMC24 @EuroMedChem
JJ’s Emma Parmee with a tour de force about chemistry success factors in drug discovery at #EFMCISMC24: Mastering structural complexity to drug more complex targets, the importance of hit ID diversity, HTE to speed up Make cycles, D2B for #PROTAC hit ID, Surf-DELs @EuroMedChem
Laboratory of biomolecular modelling and design retweeted
🚨 We have a fully funded PhD position available in the beautiful city of Leuven, Belgium, on building DNA-based artificial transmembrane nanomotors!
Check out the details and apply here: kuleuven.be/personeel/jobsit…
Feel free to email or DM me for more information!
Please RT 🙏
Laboratory of biomolecular modelling and design retweeted
I just noticed the little warning underneath the results of an AF3 job. OK, so @GoogleDeepMind will never let us use their ligand binding diffusion model. But you can't even use their protein models for ligand docking. That's ridiculous.
The worst thing about AlphaFold3 (after no code) is that you can't use a protein structure prediction to do drug development (if I read this correctly). @GoogleDeepMind must own all drugs developed from AF3. It's basically The Matrix for protein structure prediction.
Laboratory of biomolecular modelling and design retweeted
Sometimes #AFM gives you this joy! micrometer wide Protein-based 2D layers made from a Computational Designer protein. Excited to see where this protein will lead us next!
#BioAFM #AtomicForceMicroscopy #CPD #proteindesign #Nanobiotechnology @kullbmd @KU_Leuven #biochemistry
Laboratory of biomolecular modelling and design retweeted
Happy to share my recently published paper. “Structural mechanism underlying variations in DNA binding by the androgen receptor”. Congratulations to all the co-authors ! Enjoy reading :)
pubmed.ncbi.nlm.nih.gov/3860…
@MolendoKUL @kullbmd
Laboratory of biomolecular modelling and design retweeted
New opportunity! The #SAMPL challenges will be continued and their scope extended to both predictions of physical properties and FAIR+R metadata for theoretical chemistry calculations. The first #euroSAMPL challenge will start on 2024-02-19. Find more at qmbench.net/eurosampl
Laboratory of biomolecular modelling and design retweeted
Upcoming webinar by NVIDIA and OneAngstrom!
(please share!)
Pharmaceutical researchers are continually on the quest for better, faster ways to design drugs, but juggling independently designed software and data sources has created a long-standing challenge. NVIDIA and OneAngstrom are collaborating to reduce this fragmentation.
Join the discussion and see how molecular design is made more accessible than ever before by accessing powerful, state-of-the-art generative AI services through the SAMSON molecular design platform.
Date: Thursday, February 15, 2024
Time: 10:00 –11:00 a.m. PT
Duration: 1 hour
In this webinar you will learn:
- How integrative molecular modeling results in streamlined, state-of-the-art workflows for scientists
- To access NVIDIA BioNeMo™ in just a few clicks to predict protein structures and dock entire libraries of ligands
- To combine BioNeMo with all other extensions available in SAMSON for modeling, simulation, analysis, visualization, scripting, and more
Register at info.nvidia.com/transforming…
Laboratory of biomolecular modelling and design retweeted
Hi all. I hope you can please #RT this? @janhjensen @pwk2013 @macinchem @baoilleach @mattschap @EstebanezLab @kullbmd @cressetgroup @CCG_MOE @OpenEyeSoftware @MgmsUpdates Thanks for passing this along.
Laboratory of biomolecular modelling and design retweeted
Warm congratulations to PhD student Ahmed Shemy @kullbmd on winning the @IUCr Journals Poster Prize at the 10th @DiamondLightSou @ccp4_mx Data Collection and Structure Solution Workshop, shown receiving his certificate and prize from lecturer and @ActaCrystD Editor Elspeth Garman
Laboratory of biomolecular modelling and design retweeted
In only a few months, the #ABLS24 conference will take place in Leuven. Want to join but lack some funds for a trip to Belgium🇧🇪? No need to worry, as we offer 4 travel grants to junior scientists. Visit our website to submit your motivation✍: vibbio.tech/3QNYi4o
Travel Grant deadline: 14 December 2023
#bioinformatics #Computationalbiology
Laboratory of biomolecular modelling and design retweeted
Compile away, my good man, but with a cacophony of claims out there, and with new methods published all the time, I think the only way to know what’s really happening is to benchmark! #CACHEchallenges @alexanderhilli7 @mattschap @ryanmerkley
Laboratory of biomolecular modelling and design retweeted
De novo design of knotted tandem repeat proteins | Nature Communications nature.com/articles/s41467-0…
Laboratory of biomolecular modelling and design retweeted
Here is our new protein design engine. In short, it evaluates interaction energies through a single matrix operation!
We're happy to get your feedback on the early software (bio.mpg.de/damietta) or web-server (damietta.de); high-performance releases to follow.
The design of functional proteins using tensorized energy calculations dlvr.it/Sthbn6
Laboratory of biomolecular modelling and design retweeted
Please retweet!📢📢
We are looking to appoint a BBSRC-funded post-doctoral research associate to work in the area of de novo enzyme design with alpha-helical barrels using computational design, protein biochemistry, and directed evolution. More details below
Laboratory of biomolecular modelling and design retweeted
We have beautiful new structure images on our PDBe pages thanks to PDBImages, a robust and scalable new pipeline, driven by @molstar0. Plus, the code is freely available on GitHub so you can try it yourself!
🔗 ebi.ac.uk/pdbe/news/pdbimage…
