AI Engineer, Patent owner of Artificial Intelligence-assisted methodology for Medical Discovery. Tweets are mine/not medical advice or endorsements.
Joined May 2009
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1) Using a state-of-the art #AI committee (=multiple reasoning #AI engines investigating the same problem) we have two new #MECFS and #LongCOVID research targets being confirmed : a) Phosphoinositide-controlled membrane identity b) The role of RAB Proteins and prenylation.
1/ Based on research proposals listed by @weandmecfs in collaboration with @s4me_info forum, I performed a ranking based on a #AI framework reasoning consisting of multiple #AI engines. This, I believe will be the future of research proposal evaluation, along with humans
1/ My father had to be rushed to the hospital 3 days ago because of pain in the stomach. 86 years old, he is a real fighter, doing better now (Thank God). He was found to have cholecystitis because of a 2cm gallstone. Two points to say regarding #MECFS :
1/ I have been working on understanding better the reasoning abilities of several LLMs independently and when working in tandem.. I think that our knowledge for #MECFS will progress at unprecedented rates. I also wonder whether we could investigate further the recovery stories..
2/ of patients. Do we have an estimate on how many people recovered from #LongCOVID or #MECFS ? @ahandvanish do we have relevant info (regarding #LongCOVID) on this ? Having data from this cohort could significantly help us accelerate our research in my opinion.
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1/ We have a new research target been confirmed from previous analyses on #MECFS using #machinelearning and #networkanalysis methods named PGC-1α / PPARGC1A (see below - arrow). It was identified in 2017, as shown below. All annotations via circles show confirmations so far :
2/ There are now 2 studies that mention PGC-1a as a potentially important part of #MECFS. The first one is by Alain Moreau et. al and a preprint study by Hunter et. al (shown below - left and right respectively)
1/ I am currrently using an AI Framework going through 21 hypotheses (at the time of posting) related to #MECFS. Several AI "experts" rank each of these hypotheses, combine them if they believe they should be combined and then checking on each other.
2/ Here is an example. Each letter below denotes a certain hypothesis. Observe how one #AI algorithm is combining several hypotheses if this is warranted, summarizing the hypotheses to 4 main categories (in this run) :
May I also add to this discussion : Who decides which AI-generated hypotheses will pursued for further research and which not ?
I feel blessed to be able to have holidays at this moment while others cannot. Even here, new ideas for connecting the pieces of the puzzle have emerged which I will put to work as soon as I return. No quitting until we get to the bottom of this, together . #mecfs #longcovid
I am reaching out to all patient #MECFS and #LongCovid organizations and researchers. PLEASE run an efferocytosis assay study ASAP.
Here is another question : Do patients of #MECFS and #LongCovid tend to have significantly more cases of Post Inflammatory Hyperpigmentation (PIH) or not ?
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I may have found yet another piece of my health puzzle. I realized it after seeing how frequently now my fingernails need clipping : Every 4 days ! It's never been so frequent and I am wondering whether anyone noticed that since getting #MECFS, nails tend to grow much slower (?)
I feel disheartened about the state of research in #MECFS. I see very few research efforts at the moment trying systematically to understand the bigger picture. Looking at individual pieces of the puzzle isn't enough. We have to connect them.
1/ I can play tennis, having eaten anything for the past 12 hours without getting PEM afterwards. Just to be clear : if I do not follow a specific number of interventions, PEM and other symptoms come back gradually. During a chat with @ImmunoFever I was reminded....
2/ -in a very respectful way- that I am managing #MECFS, I have not recovered from it. My interventions are not activity related so no pacing is involved. If I follow them, I can do any activity given my age and fitness profile without getting PEM afterwards. Recently, I was...
Way to go @AnthropicAI . Your products could really make a difference in helping research #MECFS. Instead this is what we get (even with Sonnet !!) :
Very happy to see this research moving forward. Mycotoxin exposure can be yet another factor that negatively affects liver function (= leads to metabolic dysregulation) and could set the stage for #MECFS (hypothesis). Same for EBV, Lyme, HHV6, Q-Fever, COVID19, organophosphates
Hepatitis has been reported as the most frequent clinical form of acute Q fever (46.3%) : sciencedirect.com/science/ch…
1) In 2007-2010, the Netherlands experienced one of the biggest Q-fever epidemics ever recorded.
This new study shows that more than 10 years later, the quality of life of people with Q-fever fatigue syndrome remains consistently reduced.
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1/ After all of these years, I forgot about the importance of zinc. If you are an #MECFS, #LongCOVID patient and especially if you are male, do look at your zinc levels. Important for CYP11A1 (P450scc). Below, snapshot from my presentation at @LSHTM (2018)
