MD-PhD candidate @uoftmdphd | Researching childhood cancers | Genomics, Writing & Donut enthusiast | Learning and Unlearning
Scarborough, Ontario
Joined October 2020
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- Following1.2K
- Followers743
- Likes14.6K
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4yrs ago,@rmkhokha asked me to study the #metabolism of normal mammary epithelial cells for my MSc. Today, I share with you my 1st first-author pub in @NatMetabolism (tinyurl.com/emnk5tw).Below a thread on how studying normal cells helps us better understand #breastcancer. /1
In 2021, I tagged @KarlDeisseroth in a tweet about his book. To my surprise, he replied and we held 2 writing workshops
Despite being so busy, Karl has gone out of his way to be an incredible mentor for physician-scientist trainees!
Congrats on the well-deserved Nobel!
Check out the amazing paper by Mehdi! The genomes of relapsed pediatric cancers are shaped by the cancer therapy that was once used to eradicate them!
Watching the story unfold over the years has been a honour!
Our paper out today in @Nature:
How does prior therapy shape childhood cancer at the genomic level? 🧬
nature.com/articles/s41586-0…
rdcu.be/fvdNz
#Nature #CancerGenomics #MutationalSignatures #PrecisionMedicine #PediatricCancer #Resistance
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5yrs later, our 2nd @uoftmdphd bookclub ft @KarlDeisseroth! @kao_jenn and I asked KD how to write for papers and for prose. We revisited Projections and students shared their writing. Thank you Karl for your mentorship of physician-scientists & reminding us of the power of words
Today’s talk hosted @uoftmdphd and moderated by @mathepan and I, once again proved @KarlDeisseroth as a pioneer - this time, in bridging the gap between basic science, psychiatry, and literature. (1/4)
After years of trying to convince Maaz not to drop out of the MD/PhD program, I’ve accepted that math is his singular passion
All the best at @AnthropicAI ! Claude Maaz 5.1 coming soon to a browser near you 👀🖥️
After a gruelling 3hrs, I successfully defended my PhD today.
I finished my PhD in 3 years (a record in my department).
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Wild that the same autoantibodies to IFN-I found in life-threatening COVID-19...might actually improve response to checkpoint immunotherapy 🤯
T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too?
That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below
nature.com/articles/s41586-0…
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The "Peer Review File" is an incredible resource for students to learn the type of questions reviewers may ask and also how scientists structure and write their response to reviewers!
From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science
go.nature.com/44hKo29
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Hearing Maaz talk about how he conceived and developed a new subfield of optimization is a story for future history books of great mathematicians 🧮
EXTREMELY PROUD to share my new paper, a joint work with Adam Strzebonski (Wolfram Research).
We show how to extend all methods for polynomial programs to *algebraic functions*, a significant generalization.
To do so, we develop a novel characterization of algebraic functions!
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Honoured to win alongside #NoTwitterRob! Classmates now but will be collaborators one day soon 🤩
Super exciting to have two students win @SickKidsNews 2024 Exceptional Trainee Awards!!
@mathepan has won in Genetics & Genome Biology for his work in paediatric cardio-oncology, and Robert Lao has won in Translational Medicine for his work in paediatric cardiac surgery! 😄
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@SifanHassan's words high-key capturing my mdphd experience
youtu.be/c5Wieq6SKw4?si=6hgj…
Kicking off this year’s @uoftmdphd seminar series with bestie @mathepan !!
Pictured: post seminar drinks and a snippet of his presentation lmao
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Treats patients, directs the @uoftmdphd program, and makes incredible discoveries! Dr. Nicola Jones is the epitome of a clinician-scientist 🩺🔬
Excited to share our paper just out in Nature today! Proud of my amazing Postdoc Dr. Akriti Prashar for this outstanding work!
Self-repairing mitochondria use novel recycling system, study finds sickkids.ca/en/news/archive/…
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Fascinating papers in @CellCellPress on how Glycolysis can influence DNA damage! 🧬🔍
Yet again, the Warburg Effect shows us that it's not just about metabolism!
Venkitaraman lab: Methylglyoxal breaks down BRCA2
Zhou Lab: Adding lactate onto p53 hinders its function
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Favourite quote from today's #singlecellgenomicsday:
One man's junk can be another man's treasure in genomics - Rahul Satija (@satijalab)
@CalebLareau presented PERFF-seq, an assay to sort and profile rare cell types by using nucleic acid-based cytometry!
It's wild to think of all the diverse RNA species this assay will help us study in the future like circRNA or R loops
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RNA-based cytometry + scRNA-seq 🤯
Sorting cells based on RNA rather than cell surface markers is a game changer! I never would have thought you could sort cells based on a long non-coding RNA
To emphasize these key advantages: 1) no more unreliable or unpredictable antibodies (all programmable via nucleic acid cytometry); 2) sort non-coding genes like lncRNAs; and 3) end your sort with scRNA-seq instead of simply counting events. 8/n
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"Community is everything. It is a two-way mirror. It allows us to look outward to others. Observing the different ways we've operated in the past, present, and predicting ways in the future. But it also allows us to look inward"
Incredible words by Allysia Chin (@allysiachin)🙏🏽
SPOTLIGHT EP. 1🌟: Introducing Allysia Chin, the brilliant Black MD/PhD student reshaping medicine and research. With her exceptional talent and dedication, Allysia exemplifies Black brilliance at its finest. She's not just making strides in academia, but also plays an impactful role in her community.
She sets the bar higher. #BlackExcellence #MDPhD
@uoftmedicine @uoftmdphd @allysiachin
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Four incredible sessions featuring 12 talks from 6 oncologists, 4 cardiologists, and 2 scientists! An amazing inaugural TCON (@TOCardioOncNet) Conference to showcase the vital cardio-oncology work done in Toronto! Thank you to all who helped make this possible 🤩
Thank you to all our Chairs, Speakers, Attendees, and sponsors for a fantastic inaugural TCON Conference!
70+ participants from >22 different sites in Canada and worldwide attended!
Sign up for future events: forms.gle/hPFCMY35KEMztvVq7
Today's cancer patients will be tomorrow's cardiac patients. But why? And how do we take care of these patients? 🫀🩺
We created the Toronto Cardio-Oncology Network (TCON) to figure this out! Find out more at our upcoming Virtual Conference!
Register: forms.gle/qbfNDWBuRrNqKT5WA
Join us for the 2023 TCON Conference to bridge the gap between cardiovascular and cancer care 💓⚕️
🗓️ Fri Nov 17 from 8AM-12PM
📍 Virtual and free for all
🔬 Learn the latest cardio-onc guidelines
💡 Engage with leading experts
Register: forms.gle/qbfNDWBuRrNqKT5WA
This poster features Gairdner winners, a Nobel laureate, and then there's me with my chicken salad sandwich 😂
#GairdnerScienceWeek2023 is a week-long celebration of scientific research that impacts health and wellbeing of people around the world! Check out the incredible lineup of events and don't forget to secure your spot now!
Full schedule of events ➡️ bit.ly/GSW_2023
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Honoured to be a Vanier Scholar alongside Ann Mansur (@MansurAnn) and Robert Lao (#NoTwitterRob) - two incredible future physician-scientists 👩🏽🔬🩺
We are delighted to announce that 3 PhD students in LMP have been awarded Vanier Scholarships!
Coincidently, they are all completing or have completed MD/PhDs & researching the vascular system.
Read the full story: lmp.utoronto.ca/news/heart-t…
Check out Andy's work on Inflammatory Memory blood stem cells! Incredible work by an incredible scientist. He's doing all this while in clerkship!!
Did you know that severe inflammation leaves a lasting impact on our blood stem cells?
Excited to share our pre-print where we identified an HSC subset that remembers past inflammatory stress, which is linked to human aging and clonal hematopoiesis!
doi.org/10.1101/2023.09.11.5…
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