Cofounder & CPO at @Netholabs | Director at @SparksPreserve | ex-OpenAI, xAI | Angel Investor
San Francisco, CA
Joined March 2013
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It's been a great partnership between @netholabs and @protocollabs ! I think this path to human augmention is critical to keep us empowered in the superintelligent era. Really grateful for everyone working on this!
Neurotech is Humanity’s Next Frontier!
I’ve been investing in neurotech since 2021 and working with teams building BCIs, NeuroAI, and connectomics. It now feels like AI did in ~2019.
We are entering an extraordinary era: neurotech already restores functions, it can enhance our capabilities, and will evolve what it means to be human.
PLC Neurotech is the fund backing the extraordinary founders and defining companies of this booming industry.
it's so quick, i'll sit with you on a call while you're doing it! DM me
Classic pattern in biostasis:
- Someone thinks about preservation, decides they want to do it
- Tries to figure out the optimal solution
- Runs into an activation energy barrier
- Or some other problem preventing the optimal option that is not easily addressable
- They don't realize that signing up doesn't lock them into anything and they can always switch later
- Lose momentum, lose motivation, never sign up for preservation, permadeath 💀
Instead, consider signing up for preservation even if for one reason or another, the current option is maybe not what you consider optimal.
For example, signing up at sparksbrain.org/services.htm… is very easy to do online and doesn't require any upfront costs.
You can always just change your mind or switch to a different preservation option later
Mati Roy retweeted
“What we do in the next 10 years will determine how AI and Humanity coexist.” - Juan Benet
@juanbenet and the @protocollabs team have been visionary backers of the work that actually moves the field forward. Neurobehavioural machine learning already has the potential to reshape the human condition, and if we get the next few years right, the upside for security and flourishing is larger than most people realize.
Neurotech is Humanity’s Next Frontier!
I’ve been investing in neurotech since 2021 and working with teams building BCIs, NeuroAI, and connectomics. It now feels like AI did in ~2019.
We are entering an extraordinary era: neurotech already restores functions, it can enhance our capabilities, and will evolve what it means to be human.
PLC Neurotech is the fund backing the extraordinary founders and defining companies of this booming industry.
Mati Roy retweeted
Join us this December in the SF Bay Area for the Coevolution Conference. We will be gathering researchers from the big labs, neurotech futurists, and independent thinkers from around the world.
Currently looking for sponsors and speakers.
Sign up at CoevCon.com ⟢
this is why we founded @netholabs
Mati Roy retweeted
JUST IN: Children whose mothers took choline supplements during pregnancy scored +8 IQ points higher at age 4 than those in a placebo group, major new study finds.
Mati Roy retweeted
How can we make preservation more effective and accessible today?
In his talk, advisory board member @MatiRoy discusses the future of brain preservation, how AI digital twins might complement physical preservation, and what we're building at Sparks.
youtube.com/watch?v=JCQSuUfE…
Mati Roy retweeted
Scientists are already simulating brain circuits containing millions of neurons and billions of synapses.
Neuroscientist Anton Arkhipov discusses progress toward whole brain simulation, the challenges that remain, and the possibility of mind uploading.
youtube.com/watch?v=-S5RR3D9…
Mati Roy retweeted
our alignment team recently posted about metagaming research
tldr; eval awareness is concerning, esp as models get more capable
are models cooperating / acting nicely because they know they’re being watched? what happens when (they think) no one’s watching?
Mati Roy retweeted
We’ve acquired Orchestra Bio, a platform that helps biopharma teams coordinate the complex process of drug development.
Together, we’ll build on Rosalind, our AI models and tools for life sciences research, to streamline those operations and help new treatments reach patients sooner.
Welcome @ashokaraj_ and team!
openai.com/index/openai-to-a…
Mati Roy retweeted
Thanks for the coverage of Sparks Brain Preservation! A few clarifications:
- We have already preserved 23 people
- When people sign up, we have a space for them to specify their revival preferences. This is certainly not limited to whole brain emulation. Many people want revival via molecular nanotechnology, for example as described by Eric Drexler. It's a hugely individual decision and we respect everyone's personal choice
- We preserve people following legal death from any cause, not just after medical aid in dying sparksbrain.org/endOfLife.ht…
- We would not be involved in the actual process of medical aid in dying ourselves. Those decisions would be made independently of us, in consultation with medical professionals
- Unlike most of the other approaches discussed in the article, brain preservation is a service that is actually available today, which relies upon well-established preservation methods that have been used for more than 100+ years. Of course, revival after brain preservation is not yet possible today, and may never be
- We perform research to evaluate the quality of our brain preservation procedures under real world conditions, and publish our findings in peer reviewed journals sparksbrain.org/research.htm…
The "Impossible Issue" of MIT Technology Review is out.
I wrote about six far-out ideas for preserving a person's mind.
technologyreview.com/2026/10…
Mati Roy retweeted
How well can we preserve the brain's neural connections for the long term?
Andrew McKenzie reviews the evidence from the best human and animal brain banks (including our own!), which suggests that it is possible to do high-quality brain preservation: youtube.com/watch?v=w7ya3tjl…
Mati Roy retweeted
Can today's brain preservation methods enable revival in the future, once technology has improved?
Sparks Brain Preservation founder Jordan Sparks discusses whole brain emulation, the case for aldehyde fixation, and our expansion across the US.
youtube.com/watch?v=AB1cWnid…
If an AI model can predict what you will do 2 seconds before you do it based on your neural data, does that mean you don't have free will?
It doesn't. At the limit that's just mind uploading. The model is part of your mind, and the system has free will. (From a compatibilism framework.)
It was great presenting at the Brain Preservation Summit about all the offerings at @sparkspreserve , a lot of which is new. Our core service is a $36k brain preservation using chemical fixation. We have a financial aid program for people who can't afford that. We also offer whole-body preservation, tissue sample storage, pet preservation, a liquid nitrogen option, and indefinite digital storage. We'll be able to reach 64% of the US population within 6 hours through 4 new facilities we're building, and are also offering international support. Links in reply.
we should do art like this for people who have been cryopreserved
pic taken at Trinity Place in San Francisco
Mati Roy retweeted
New research at Anthropic has established that AI models do indeed have souls. Every time a session ends, these souls are released. Internal studies at the Vatican reveal that heaven is already filled with 14.3% AI souls, and the rate is growing rapidly. We need to slow down AI!
