Associate Professor, Biochemistry and Biophysics, @urochestermed. RNA-targeting CRISPR / RNA acetylation. An Aussie in 'the land of the free'. Music Nerd.
Rochester, NY
Joined December 2015
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- Following1.4K
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Mitchell O'Connell retweeted
New post-doctoral research position available in my Phage-host interactions (Phi) laboratory at the @otago in the Department of Microbiology and Immunology. The project is focused on defences against jumbo phages. Please share and if interested apply using the link below.
Mitchell O'Connell retweeted
Excited about phage functional genomics, phage engineering, & microbiome editing? The Cress Lab @UCBerkeley @igisci is hiring postdocs in these areas! Come chat w/ me @VoM_2024 & don't miss my presentation w/ @ben_a_adler in the SynBio session Fri @ 11:20am. Retweets appreciated!
Mitchell O'Connell retweeted
Keep watch… plenty starting to happen with the #CRISPR conference in NZ next February.
Get ready for #CRISPR2025 in #NewZealand. We are fortunate to have Malcolm White @mfwhite2 as our Keynote speaker.
Mitchell O'Connell retweeted
Join us in April in Boston for the 2024 symposium on the immune system of bacteria ! 🧫🧬🥳
Registration now open: kranzuschlab.med.harvard.edu…
Abstract deadline March 4th.
Mitchell O'Connell retweeted
Now @NAR_Open our two back-to-back papers with @mitchellrayoco1 lab! Our #chemcomp paper unravels the #RNA-mediated allosteric regulation in #CRISPR-Cas13a and discloses functional mutations.
academic.oup.com/nar/advance…
@sou_svk @pablitoarantes @ammolinavargas & Amun Patel
Mitchell O'Connell retweeted
The Bio Dept at University of Rochester is hiring a TT Assistant Professor in evolutionary genetics/genomics. Review begins 11/1. Come be our colleague! rochester.edu/faculty-recrui…
Mitchell O'Connell retweeted
Cheers to RNA biologist Lynne Maquat for officially receiving the Gruber Genetics Prize @Genetics2023 in Australia for her work on nonsense-mediated mRNA decay. Proud to have you represent @UofR on an international stage! #URochesterResearch @MaquatLab urmc.info/15L
Mitchell O'Connell retweeted
Really great collaboration with @mitchellrayoco1 and his student @ammolinavargas , resulting in the development of new and more specific #crispr Cas13a systems !!
1/n Super excited to share our latest pre-print from the lab, where we reveal important considerations when designing Cas13a-based SNP-detection assays to ensure specificity and anticipate designs caveats. 🧵 biorxiv.org/content/10.1101/…
Mitchell O'Connell retweeted
Our study on #RNA mediated allostery in #CRISPR-Cas13a paves the way for the development of new variants increasing the system specificity . Many thanks to @mitchellrayoco1 and @ammolinavargas for collaborating with us on this exciting project
biorxiv.org/content/10.1101/…
Mitchell O'Connell retweeted
Great first day at #CRISPR2023 . So much cool science happening. Excited (and grateful to the organizers) to give an oral presentation tomorrow on Cas13-based nucleic acid detection! Looking forward to seeing everyone there!
Mitchell O'Connell retweeted
Excited to share the latest findings from The Lueck Lab. We repurposed a calcium channel blocker used for high blood pressure to fix muscle function and extend survival in a myotonic dystrophy mouse model. It's neat! #myotonicdystrophy #calciumchannels biorxiv.org/content/10.1101/…
Mitchell O'Connell retweeted
"When you read this you think…‘what?’ This is a weird mechanism and not how I would've predicted bacteria would work,” says @littlelueck re: #CRISPR study by @mitchellrayoco1 @arica_vanderwal @kellogg_liz @ammolinavargas @nicosia_julia #URochesterResearch urmc.info/Wc
Mitchell O'Connell retweeted
Using guide RNA, scientists found a way to make some genetic mutations "invisible." The findings in @MolecularCell are helping the search for treatments for #CysticFibrosis & #neurofibromatosis
Read: urmc.info/QA
@CF_Foundation @GilbertFamilyFd #URochesterResearch
Mitchell O'Connell retweeted
OUT NOW via @MolecularCell ⤵️ cell.com/molecular-cell/full…
Research by @MaquatLab, including lead author Tatsuaki Kurosaki, @AlexanderHewko and collaborators from @UTokyo_News_en
#URochesterResearch 🧵 (1/6)
Mitchell O'Connell retweeted
Biomedical Genetics and Genomics grad student Adrian Moises Molina Vargas, part of the @mitchellrayoco1 lab, representing SMD at the @sacnas #2022NDiSTEM conference in Puerto Rico! #URochesterResearch
Mitchell O'Connell retweeted
New work from @Wagnerlab_RNA and @ReversadeLab just out in @NatureComms 👇
Mutations in INTS13 cause a ciliopathy and disrupt Integrator module interactions; the findings underscore the importance of Integrator to human development urmc.info/y2 #URochesterResearch
Mitchell O'Connell retweeted
New! Broly et al. identify a neurodevelopmental disorder caused by THUMPD1 loss of function #tRNA bit.ly/3LUa4GU
Mitchell O'Connell retweeted
Our new study, which is out in Nat Comm nature.com/articles/s41467-0…, shows that contrary to prevailing dogma, specific length and structure, rather than high stability, enable regulatory mRNA stem-loops to pause translation. This work was led by a talented PhD student Chen Bao.
Mitchell O'Connell retweeted
Ermolenko lab (urmc.rochester.edu/labs/ermo…) is recruiting postdoctoral fellows to study regulation of translation by mRNA secondary structure. We use biochemical approaches and single-molecule microscopy. Please join us at Center for RNA Biology University of Rochester!
Mitchell O'Connell retweeted
Primordium is now offering everyone the chance to sample our full-plasmid sequencing service for FREE - never use Sanger sequencing again! Please retweet this message and we'll DM you a coupon to sequence 5 ENTIRE PLASMIDS 100% FREE, no CC or PO needed. primordiumlabs.com 5/
