@nephrobug

nephrologist, MD, PhD, genetic kidney disease and rare kidney disease in Saint Joseph hospital and C2VN lab

 Marseille, France
Joined September 2011
  • Tweets2.7K
  • Following4K
  • Followers1.9K
Our paper in Joint Bone Spine shows the first link between a novel CNNM2 variant & early-onset CPPD. The variant drives renal Mg wasting → chronic #hypomagnesemia. This expands the CNNM2 phenotype & urges genetic testing in atypical #CPPD. sciencedirect.com/science/ar…
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Nephrologists! Check out this new series of review articles published by @MassGenBrigham researchers on genetic nephrology: doi.org/10.1016/j.semnephrol… @janewitwong @MGBKidneys
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🥸2️⃣0️⃣ These findings highlight the need for caution when considering aspirin for primary prevention in older adults. In this population, long-term use *may* not be associated with cardiovascular benefit and bleeding risks remain a concern.
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thomas robert retweeted
NDT@NDTsocial11 Aug 2025
🎥Watch Dr Laurent Mesnard present the NDT publication: CKDx is a good start - But can we go further? oup.cloud.panopto.eu/Panopto…

CKDx is a good start - But can we go further?

Presented by Laurent Mesnard Article DOI: https://doi.org/10.1093/ndt/gfaf138

oup.cloud.panopto.eu
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Just out in Nature Reviews Nephrology. Kidney stone disease: risk factors, pathophysiology and management. nature.com/articles/s41581-0…
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thomas robert retweeted
NDT@NDTsocial12 Aug 2025
🧐Read this interesting debate in NDT! *CKDx: a necessary step—but can we go further? 🆓doi.org/10.1093/ndt/gfaf138 *CKDx: simplicity matters, implementation is key 🆓doi.org/10.1093/ndt/gfaf137
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The debate on #CKDx classification continues! We’ve read the reply from the @ERAkidney G&K group. They champion simplicity over precision. A thread 🧵:
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3/ Quoting Osler seems wise. But be caution in applying 19th-century reasoning to 21st-century Let's him in peace. 🕊️ They say: “Simplicity matters” We say: “Ambiguity is not simplicity.” #Nephrogenomics @com_SFNDT @FiliereORKiD @NDTsocial @ERAkidney @Laurent_Mesnard
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Read their full response here: academic.oup.com/ndt/article…

CKDx: simplicity matters, implementation is key

We would like to thank the authors for their interest in the CKDx statement. While we are delighted to see that, in essence, the authors agree with the gen

academic.oup.com
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💡 CKDx is a good start — but can we go further? 🔍 🚀 Exploring the strengths & limits of CKDx — and how we can push precision nephrology to the next level. @Laurent_Mesnard 🎥 oup.cloud.panopto.eu/Panopto… 🧬 #Nephrology | 🧪 #Genomics | 🎯 #PrecisionMedicine
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thomas robert retweeted
NDT@NDTsocial8 Aug 2025
📽️Watch Dr Laurent Mesnard present the NDT publication: CKDx is a good start - But can we go further? oup.cloud.panopto.eu/Panopto…

CKDx is a good start - But can we go further?

Presented by Laurent Mesnard Article DOI: https://doi.org/10.1093/ndt/gfaf138

oup.cloud.panopto.eu
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CKDx: a necessary step—but can we go further? academic.oup.com/ndt/article…

CKDx: a necessary step—but can we go further?

The classification of chronic kidney disease (CKD) without a definitive diagnosis, such as CKD of unknown origin (CKDu), remains a major clinical challenge

academic.oup.com
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Nephrogenomics, precision medicine and the role of genetic testing in adult kidney disease management nature.com/articles/s41581-0…

Nephrogenomics, precision medicine and the role of genetic testing in adult kidney disease manage...

Nature Reviews Nephrology - This Review examines the use of pangenomic analysis to improve molecular diagnoses in adult nephrology, including available sequencing methods and their applications....

nature.com
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Ongoing discussion about UACR or UPCR in glomerulonephritis captured by @NDTsocial Albuminuria predicts kidney events in IgAN academic.oup.com/ndt/article…
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🧬 Our review on nephrogenomics in adults is out in Nature Reviews Nephrology! From diagnosis to therapy and precision care — including long-read sequencing & ethical issues. 📖 doi.org/10.1038/s41581-025-0… #Nephrology #Genomics #CKD #PrecisionMedicine

Nephrogenomics, precision medicine and the role of genetic testing in adult kidney disease manage...

Nature Reviews Nephrology - This Review examines the use of pangenomic analysis to improve molecular diagnoses in adult nephrology, including available sequencing methods and their applications....

nature.com
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🔬 Faster time-to-diagnosis 🌍 But disparities persist: low representation in databases, lack of standardization
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💡 Conclusion: Nephrogenomics isn’t just for pediatrics. It’s time to integrate it into routine adult nephrology.
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