Heme/Onc fellow @Mayoclinic via @clevelandclinic Fairview Internal Medicine🇳🇬🇺🇸 Translational research/Leukemia/Clonal hematopoiesis
Joined November 2010
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🧵 What happens to clonal hematopoiesis during the intense inflammatory stress of sepsis? 🩸
Excited to share our newly published work examining emergency hematopoiesis and clonal dynamics in sepsis.
@tariqkewan @CarmeloGurnari @VisconteValeria
Here’s what we found 👇doi.org/10.1002/hem3.70495
The signal replicated in All of Us: sepsis-associated leukocytosis was associated with ~2× higher odds of CH.
Among patients ≤60, CH prevalence was nearly 4× higher in sepsis vs matched controls.
Longitudinal sampling also revealed dynamic clonal trajectories—persistence, contraction, and apparent emergence of clones after recovery.
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Together, these findings support a model in which emergency hematopoiesis during severe inflammatory stress may contribute to clonal expansion.
This was truly a team effort. Grateful to our collaborators and mentors across @ClevelandClinic, @YaleCancer
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Olisaemeka Ogbue, MD retweeted
What happens in the bone marrow clonal dynamics during sepsis? We studied by looking at emergency hematopoiesis in the ICU setting 👇@ClevelandClinic @Yale #CHIP @aamdsif @MDSFoundation @olisaogbue
Olisaemeka Ogbue, MD retweeted
doi.org/10.1002/hem3.70495
🧬 Sepsis-associated emergency hematopoiesis may promote clonal hematopoiesis (CH). @olisaogbue @CarmeloGurnari @VisconteValeria @ClevelandClinic @Yale
Olisaemeka Ogbue, MD retweeted
ICYMI: @eaonc announces its 2026 Scientific Leadership Award recipients—leaders shaping the future of #CancerResearch and care. Congrats to @ValsamoA, @jordanberlin5, & @olisaogbue! Learn more: bit.ly/3QhH1Ex #ClinicalTrials #OncologyResearch
Olisaemeka Ogbue, MD retweeted
Promoter TERT-Related Hematopoietic Somatic Mosaicism in Patients With Telomere Biology Disorders - PubMed #pTERT #CH #TBD Maddie Franke @MayoClinic tells a beautiful story on Darwanian adaptation to HSPC fitness constraints pubmed.ncbi.nlm.nih.gov/4229…
I’m deeply honored to receive the 2026 #EAOnc Paul Carbone, MD Fellowship Award. Thankful to my mentors at Mayo Clinic for their guidance, encouragement, and investment in my development @MrinalPatnaik @AlkaliDr @AntoineNSaliba @tariqkewan @MayoCancerCare @MayoHemeOnc @eaonc
Congratulations to @olisaogbue of @MayoClinic on receiving the 2026 #EAOnc Paul Carbone, MD Fellowship Award! #PredictiveModeling #LateEffects #CancerSurvivorship #AYACancer
Olisaemeka Ogbue, MD retweeted
Congratulations to @olisaogbue of @MayoClinic on receiving the 2026 #EAOnc Paul Carbone, MD Fellowship Award! #PredictiveModeling #LateEffects #CancerSurvivorship #AYACancer
🔥 Published just in time for #ASH2025!
“Inherited DNA Repair Variants Are Associated with Clonal Hematopoiesis and Cardiovascular Risk in Men with Metastatic Prostate Cancer.”
A brief thread ⬇️🧵
@MrinalPatnaik @OsamaMosalemMD @MayoCancerCare
haematologica.org/article/vi…
What this means clinically:
🔹 CH may help guide surveillance as PARP inhibitors and radioligand therapies move earlier in treatment.
It also offers a window into therapy tolerance and long-term hematologic risk in mCRPC.
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