Born too late to explore the world, born too early to explore the universe, but just in time to drive combustion engine cars across the American highway

So I did the whole revoke X sessions thing that went viral yesterday Then I learned Offline Downloads is tied to sessions and not even the links persist on cloud (obv download doesn’t) so months of downloads are gone Also now certain premium features aren’t working on mobile or desktop lol

I like how “DeFi” this time around is all about enforcing rules, limiting permissionlessness and holder agency, and building out the technical infra that institutions like the European Union will eventually use to control where you can spend your crypto and what you can spend it on

Watched like 20 gaming crypto projects from last cycle pivot from super cool world building games to Vampire Survivor clones and other ADHD mobile style games on Steam in a desperate attempt to chase revenue Horrible experience. Thankfully with the incoming decrease in game dev costs we’ll likely never have to experience that again

These gacha packs are just the millennial generation’s version of the boomer slot apps

After seeing what they did to Jack Duval today being robbed at knife point doesn’t seem that bad

Upeg had 3 separate “strategy” tokens attacked Txn hash: 0xc9796d4948714d7e37c68784ec64117d3481f03e852200bb72175c283ecb18a4 Attacker took a balancer flash loan for 247.8ETH, bought up token supply for the 3 STR tokens ($UPSTR and 2 different tickers $UPEGSTR), then bought 122.5ETH worth of $UPEG to hit all the old standing sell orders of these strategy tokens In the same txn, the attacker himself executed the public functions for each STR token contract to buyback and burns their native tokens which were already inflated by the attacker’s buys. The attacker then sold all the STR tokens and the UPEG he had bought and repaid the flash loan The attacker filled 32 standing $UPEG sell orders from the STR tokens for ~33ETH, made about +31ETH profit from the STR tokens and about -31ETH loss on the $UPEG pump and dump. Crazy part (someone can double check the math here) the attacker paid .53ETH of his own ETH upfront in gas bribe and sent .59ETH to the attackers wallet at the end of the attack, meaning he made a profit of 0.06ETH for this attack or roughly $150 Of the 3 strategy tokens, two of then had about 10x the sell orders and buybacks of the 3rd smaller token. Because 10% of volume on these tokens goes into new $UPEG inventory, the attacker ran the same attack again an hour later on the 2 larger STR token with a 10ETH flash loan to hit the new orders his first attack had created, and made .126ETH profit in this attack. Made about 2x profit of the the first attack with only 10ETH because he didn’t pay a gas bribe on the second attack Txn hash of second attack: 0x796c1602e31bacb633548f7f5e88eb06514ce24fb8f2354342116dd18baf631a $UPEG price decreased from these attacks and the STR tokens all lost their inventory sell orders of the $UPEG they held, which ended up back in the $UPEG LP

Within a few years we’ll have the Star Trek food replicator which will have every distinct food molecule and allow you to AI generate any recipe you can imagine

Every blockchain that shuts down is bullish ETH/SOL. Every L1/L2 that raises 9-figures and goes to zero is bullish ETH/SOL Block space means nothing without liquidity. Anyone can spin up new block space, you cannot just spin up liquidity Security is a requirement for deep liquidity. People frequently underestimate this as a requirement for deep liquidity until we see real examples, like Ronin L1 being hacked for $620M before migrating to become an ETH L2 to inherit Ethereum’s network security. Every appchain that uses Ethereum for settlement has to pay for that settlement in ETH Network effects in crypto are where liquidity is deepest, least subsidized, with the longest timeframes, and where security is the strongest, most decentralized, with the longest track record without disruption. If you want to identify the top networks, check stablecoin TVL and specifically where stablecoin TVL is not subsidized in any way

How tf is SI down today

I applied to my alma mater UC Berkeley as Hispanic instead of White. Hispanic is not a race and literal meaning is “a person connected to the Spanish language or a country with Spanish heritage”. My grandmother is 100% Spanish, we have documented lineage of Spaniards in California and New Mexico dating back to the early missions, before the west coast was part of the United States. My mother’s side is about as “Hispanic” as it gets based on the definition But do you think the UC Berkeley admissions office expects a blue eyed white guy who doesn’t speak any Spanish with zero blood native to the Americas when they joyously accept the “Hispanic” application and carve their chicken scratch on the DEI wall? Probably not haha

After seeing the omega-3 truther posts come out I spent an hour reading this study today. Here’s summary: They gave mice fish oil every 3 days, equivalent to about ~15-20G dose in humans. They gave these mice mild traumatic brain injuries and continued giving fish oil for 6 months after. Also had control groups with: 1) no fish oil + tbi, 2) fish oil no tbi, 3) no fish oil no tbi First important conclusion of the study was that DHA (omega-3) did serve an important role in repair for all groups as a structural component of neuronal membranes, especially at synapses. DHA is also the precursor to neuroprotectin D1 and D-series resolvins which are mediators tied to acute post-injury benefits The negative findings were exclusive to EPA (omega-3) They were not looking for rancid oil in these supplements but do note that they didn’t find significant increases of toxic byproducts, like twitter might suspect. They found insignificant increases in the toxic aldehyde 4-HNE, which is actually a byproduct of omega-6 peroxidation, not omega-3s. They did not report any increase of 4-HHE which is the primarily toxic aldehyde produced from omega-3 peroxidation They found EPA accumulates as a reservoir in the brain and is preferentially and rapidly used for fuel after a traumatic brain injury (TBI) by the endothelium. In the injured mice it continued be used for fuel for long after the injury. Directly after a TBI, the brain enters a metabolic crisis where it rapidly consumes glucose. Neurons are poor fatty acid oxidizers, but the endothelium (what this study found having maladaptive issues from EPA) can burn fatty acids. So it appears the endothelium uses up the EPA while glucose is mostly consumed by neurons Basically what they found in the maladaptive mice was a change in gene expression in the endothelium: Structural matrix and vessel-stability genes went down (agrin, collagen IV, claudin-5, Pecam1, Cxcl12) and fibrotic matrix genes went up (Tgfb2, collagen VIII). Fatty-acid handling genes went up (PPARα, Fabp3, Cpt2, Acaa2) The brain endothelium shifted gene expression into fatty acid consumption, shifting away from glycolysis which is needed for repair. Sprouting new endothelial vessels depends on PFKFB3-driven glycolysis So basically the issue is the endothelium shifted over to fatty acid burning as an emergency energy fuel source during the TBI metabolic crisis, and because it remained saturated in EPA, got stuck in that gene expression and never switched back to a glycolytic, angiogenic state needed for repair Very interesting study with implications for how EPA operates in the brain post-TBI and gene expression, but there’s many conclusions this study does not support: >Omega-3 fats being bad for the brain: DHA still important to post-tbi repair and neuronal function and protection. This is the finding of many other animal and human studies >Having an EPA reservoir being a bad thing when experiencing a TBI: it provides an alternative fuel for the endothelium during the metabolic crisis. EPA can compete with arachidonic acid and feed E-series resolvins, which can also buffer inflammation during the acute phase of TBI recovery >That all doses and amounts of omega-3s prevents a glycolytic state for healing. The standard diet mice were not 100% devoid of all omega-3, just not taking saturating bolus doses. The issue seemed to be when enough EPA was given where the endothelium could continue using it for fuel long after the TBI metabolic crisis Personally I don’t take omega-3 supplements. I get my omega-3 primarily from grass fed, grass finished beef which can have a 2:1 to 3:1 omega-3:omega-6 ratio instead of the corn fed beef 15:1 to 20+:1 ratio. I also get it from fresh salmon. I wonder if these people on X think grass fed grass finished beef is toxic for the brain, or if they even have the capacity of thinking that far into their claims

Without fail whenever the meta becomes sending money to big non-crypto accounts and influencer grifts, it’s a great time to sit in your long term holds and touch grass for a few days

If I had to narrow it down to 9 left panel but had to create an honorable mentions because too many games shaped me

They’re desecrating everything you once loved

We are here in the stock pair meta