Exploring & engineering bacterial #naturalproducts at @ETH Zurich Institute of @Microbio_ETH | Therapeutic lipopeptides by @AnnaVagstad | Run by lab members
Zurich, Switzerland
Joined February 2019
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Congrats to @HubrichFlorian & @sanathrajkk0 for this exciting story finally being published. Thanks for the fruitful collaboration with @chekanlab. If you are interested in the chemical space of #RiPP #biosynthetic #enyzmes and #isoprenoids, click here:
sciencedirect.com/science/ar…
We are super proud of @MrMunsterberg for winning the #DiscoveryAward2024 at the #ICNPR2024 last week! Very well deserved, Johannes. Keep following us to stay tuned for updates on his amazing research!
We are having a great time being @ETH_DBIOL symposium in #Davos again. Listening to fantastic talks, discussing science on posters and of course socializing with peers.
Are you interested in peptide natural products and especially post-translationally modified peptides? Check out this review by our @danirichterfl on ribosomally synthesized and post-translationally modified peptides (RiPPs) here:
sciencedirect.com/science/ar…
The review summarizes advancements in the field during the past two years - which are numerous, considering the rapid pace and the talented groups working on RiPPs.
Our review is part of a special issue on Biocatalysis and Biotransformation, edited by Ikuro Abe and Taifo Mahmud. Don't forget to check out the other articles in the collection at sciencedirect.com/journal/cu…
... and stay tuned because new articles are still being released.
Check out our recent News & Views by Anna Vagstad and @danirichterfl highlighting an article by @Nairlab_UIUC. Unusual LanM architecture enables the biosynthesis of dehydrazoles
nature.com/articles/s41589-0…
#RiPPs #NaturalProducts #Enzyme
In beautiful biochemical work they show the azole-dependent installation of dehydroamino acids here:
nature.com/articles/s41467-0…
Thank you @ScienceMagazine for highlighting our paper here!
New in Science: Approaches used in two independent studies are an important step forward for rational engineering of large enzyme complexes for small-molecule drug discovery and production.
Learn more ⬇️
📄: scim.ag/6qs
📄: scim.ag/6qr
An amazing team effort brings us one step closer cracking the nut of #polyketidesynthase reprogramming. In our new paper published in @ScienceMagazine, we shed light on #Engineering these multimodular assembly lines used for #naturalproduct #biosynthesis.
science.org/doi/10.1126/scie…
For a brief summary, make sure to also check out the 🧵written by @Mathijsfjm:
xitter.cf/Mathijsfjm/status/1771…
...and last but not least, make sure to not miss this amazing piece of research also published @ScienceMagazine by @HelgeBode_Lab and covers the #reprogramming of #NRPS for cool new #peptides. What a day in #naturalproductresearch!
science.org/doi/10.1126/scie…
Congrats to @AnnaVagstad bringing this amazing story to the finish line! Thank you to everyone involved from @BroderickLabFeS for the fantastic collaboration! If you are interested in the enzymatic mechanism of peptide epimerization by rSAM, make sure to read it.👇
📷
Detection of the α-Carbon Radical Intermediate Formed by OspD: Mechanistic Insights into Radical S-Adenosyl-l-methionine Peptide Epimerization |Journal of the American Chemical Society @montanastate #Radical #Detection #OspD #SAM #Peptide #Epimerization pubs.acs.org/doi/10.1021/jac…
We are very proud of @Mathijsfjm for starting his own research group and even more exciting to see what amazing research will come from his lab! Stay tuned for exciting projects 👨🔬🧫⚗️
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We are very proud of @aefraley for being one of these professor! Stay tuned for amazing research coming from her lab👩🏫👩🔬🧫⚗️
On the proposal of ETH Zurich President @Joel_Mesot
, the ETH Board appointed 12 professors and awarded the title "Professor of Practice" once. 👨🏫👩🏫 brnw.ch/21wF6YH @MortezaAramesh @ellliottt
Exciting news! Did Acidobacteria also pop-up in your MAGs? In our new paper we identify sponge-type polyketides from this unusual phylum:
sciencedirect.com/science/ar…
Have a read for more details. We are excited to see where else we can find Acidos!
Go Johannes @MrMunsterberg! We are all excited about you presenting your amazing research! 💪🏽
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