Assistant Professor @Stanford_MCP; Membrane protein biogenesis; Protein quality control; #nanobodies, #FirstGen (He/Him); Now only on https://xitter.cf/t.co/IwPmoXJmVu
Stanford, CA
Joined October 2019
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Tino Pleiner retweeted
The ER membrane protein complex acts as a chaperone to promote the biogenesis of multi-bundle membrane proteins biorxiv.org/content/10.64898… #biorxiv_cellbio
We made nanobodies that make your heart🫀 stop 🛑beating. Keep reading to learn how this taught us about how large membrane proteins like ion channels are folded and assembled in human cells. Beyond excited to share my lab's first preprint: Please 🔄 bit.ly/49A0PtD
We found that EMC engages the Ca2+ channel co-translationally as part of a large ribosome-multipass-translocon-EMC supercomplex, likely to protect vulnerable channel folding intermediates from misrecognition by ER quality control. We anticipate that other multi-bundle channels
and transporters face similar problems and require chaperone protection in the membrane. Amazing teamwork @Stanford @Stanford_MCP Congratulations to all authors with and without X accounts @SingalBharti @MahamayaBiswal @CS59793 @CaseyGifford
I won't be posting on this platform anymore. Please consider following us on pleinerlab.bsky.social
Tino Pleiner retweeted
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology
biorxiv.org/content/10.1101/…
Happy holidays from the @pleinerlab. Feeling so lucky to get work with this incredible team @Stanford_MCP Come join us as a postdoc to work with #membrane proteins and rewire cellular processes with #nanobodies. Apply here: bit.ly/_Postdocs ... please share 🔃
Tino Pleiner retweeted
Very excited to present the structural and mechanistic basis for stress response silencing by the monster E3 ligase SIFI.
biorxiv.org/content/10.1101/…
Tino Pleiner retweeted
We believe we need better tech to measure what cells are doing and to precisely control their behavior to crack the many mysteries of biology. These mysteries keep us curious, inspired, and excited. We're recruiting at all levels - reach out if you're interested in joining us!
Welcome to Day 1 of our Meet the Investigators series! We’re kicking off with our Core Investigators. 🧬🔬
The human body is filled with spectacular and fundamental mysteries. How do cells change over time and with disease? How do they communicate? How can we harness cellular behavior to improve health?
By interweaving molecular engineering, synthetic biology, and genomics, new Core Investigator @FelixHorns develops novel technologies to illuminate cellular and tissue-level processes in the body.
His lab’s latest: COURIER, a system that lets researchers tap into cellular communication networks so they can eavesdrop and even influence cellular behavior in real-time without damaging cells.
Felix will also join @Stanford as an Assistant Professor of Genetics later this month.
Learn more about how he and lab are decoding cellular behavior: arcinstitute.org/labs/hornsl…
Tino Pleiner retweeted
I am excited to join @CaltechCCE @Caltech as an Assistant Professor this November!
The Fianu Lab will be a welcoming space for anyone interested in gene activity and genome stability. bit.ly/47gH9I7
We are looking for team members at all levels—please reach out!
Tino Pleiner retweeted
Thrilled to share our preprint on the structure of a nautilus-like assembly of membrane proteins, HflK/C, that regulate the FtsH AAA protease activity, a key component of bacterial inner membrane protein degradation machinery. (1/n)
bit.ly/4dotfpJ
Tino Pleiner retweeted
I'm thrilled to announce that the Blythe Lab will open in the Department of Genetics, Cell Biology and Development at the University of Minnesota, Twin Cities in early 2025! (1/2)
Tino Pleiner retweeted
The article is online, but the research continues. Looking forward to more exploration of protein lipid interaction in the future!
nature.com/articles/s41586-0…
Tino Pleiner retweeted
Come join us at @Stanford! We are recruiting those with background in infectious disease modeling and interest improving public health!
Postdoc (Stanford, United States)
Modeling infectious diseases and public health control strategies
with @nathanlo3579
at @Stanford
More details: iddjobs.org/jobs/stanford-po…
Tino Pleiner retweeted
Two exciting postdoc positions in my lab for a microbiologist and cell biologist to study the structure-function of ATP-dependent AAA machines! Ideal for candidates seeking an academic career. bit.ly/3JWkW7z
For more information, visit: sites.wustl.edu/ghanbarpour/
Tino Pleiner retweeted
We're hiring! Looking for a Life Sciences Technician II to help us acquire RNA structural data on 1 billion diverse molecules: careersearch.stanford.edu/jo…
Tino Pleiner retweeted
A checkpoint function for Nup98 in nuclear pore formation, elucidated with nanobodies. Congratulations to the entire team @mpi_nat @GunkelPhilip @pleinerlab !
A nanobody toolkit for tracking or blocking nuclear pore complex (NPC) biogenesis identifies a checkpoint linking assembly of the NPC scaffold to formation of the Np98-dominated permeability barrier
Dirk Görlich and coworkers
@NPC_aficionado @mpi_nat
embopress.org/doi/full/10.10…
