Antibody–virus interactions under force 🔬 This study compares the nanomechanical stability of antibodies & nanobodies bound to SARS-CoV-2 variants, revealing distinct responses shaped by binding architecture, epitope geometry & viral mutations. pubs.rsc.org/cp/article/28/1…

From patient sample to therapeutic nanobody: how does ALADDIN work? 🔬 🎯 Target identification 🧬 Nanobody discovery 🤖 Optimisation 🐟 Preclinical validation By connecting these steps, we build an integrated workflow for faster nanobody discovery. aladdin-project.eu/about/

8 partners, 1 goal: accelerating nanobody discovery 🧬 ALADDIN brings together experts from clinical science, zebra fish models, mathematics, AI, microfluidics, biotech & innovation @CNB_CSIC @HebrewU @INLnano @liu_universitet @SaludISCIII @Hospital_FJD @InCellia @ZirkaInnotech

Can nanobodies help prevent preterm labour? 🧬 A new study identifies an oxytocin receptor-targeting nanobody with antagonist activity comparable to Atosiban, while showing greater subtype selectivity. nature.com/articles/s41467-0…

Nanobodies can target disease with remarkable specificity. But discovering them is: 🕐 Slow 💸 Expensive 🚫 Dependent on specialised equipment & animal testing We develop a platform integrating multiple technologies to accelerate nanobody discovery. aladdin-project.eu/

What can mathematics tell us about cancer treatment? 🧮 In this interview for our blog, InCELLiA Founder & CEO @GeorgiosLolas shares how his team is putting mathematics to work in ALADDIN! Read the full article: aladdin-project.eu/aladdin-p… #ALADDINproject #EICPathfinder @EUeic

New work from ALADDIN researchers: How can we benchmark AI for antibody structure prediction? 🤖 Researchers from @HebrewU & IBM Research introduce SABLE, a leakage-aware benchmark designed to make deep-learning evaluation more reproducible. 🔗 biorxiv.org/content/10.64898…

Our blog series, “ALADDIN partners in the spotlight”, returns! 💡 In this latest entry, we talk with PI @GeorgiosLolas from @InCellia about his team’s work and the role of mathematical modelling in the project. Read the full interview: aladdin-project.eu/aladdin-p…

One platform bringing together multiple technologies to accelerate nanobody discovery 🔬 ALADDIN combines: 🦠 Bacterial nanobody libraries 🤖 Artificial intelligence 💧 Microfluidics 🐟 Zebrafish cancer models 📊 Mathematical modelling aladdin-project.eu/ @EUeic

Making nanobodies more sensitive 🧬 Researchers engineered nanobodies into multimers to boost antigen capture. The resulting 14-mer showed more than 10x greater antigen-capture capability, improving the sensitivity of immunoassays such as ELISA. pubs.rsc.org/ra/article/16/5…

Nanobodies have unique properties, making them promising candidates for developing targeted therapeutics. 👩‍🔬 We are harnessing this potential, with the aim of making nanobody discovery faster, more precise & less dependent on traditional approaches. aladdin-project.eu/about/

Producing nanobody mixtures could become simpler & more affordable 💡 Researchers developed a one-pot approach with E. coli to produce oligoclonal nanobody mixtures, streamlining the route to broad-spectrum therapeutics such as recombinant antivenoms 🐍 pubmed.ncbi.nlm.nih.gov/4206…

2nd review meeting ✔️ Yesterday, we presented our work from the second reporting period to @EU_Commission. The discussions will help us move towards the final project phases! 💡 @CNB_CSIC @HebrewU @INLnano @liu_universitet @SaludISCIII @Hospital_FJD @InCellia @ZirkaInnotech

Can nanobodies help clear amyloid from the brain? 🧠 Researchers have developed an anti-amyloid nanobody-Fc fusion protein designed to harness microglial activity to promote the clearance of amyloid-β, a hallmark of Alzheimer's disease. alz-journals.onlinelibrary.w…

More efficient & ethical discovery of cancer therapeutics 🧬 Identifying & validating nanobodies is a complex process involving multiple steps. We aim to streamline the journey by developing a new platform for their discovery & preclinical validation! aladdin-project.eu/

A new platform to visualise biology in action 💥 Researchers from @EinsteinMed, @salkinstitute and @helsinkiuni developed a multicolour nanobody platform that enables specific, background-free imaging of proteins & cellular processes in living systems. nature.com/articles/s41592-0…

Meet the ALADDIN researchers! 🎥 How are targets for cancer therapies identified? Javier Martínez from Instituto de Investigación Sanitaria Fundación Jiménez Díaz shares how his team identifies & validates therapeutic targets for nanobody development. youtube.com/watch?v=QuBDC_Hg…

Meet the ALADDIN researchers! 🎥 How can we turn discoveries into future therapies? Rodrigo Barderas from @SaludISCIII explains how his team identifies therapeutic targets & evaluates nanobody candidates, bridging basic research & clinical application. youtube.com/watch?v=dmv2Dxo7…

Meet the ALADDIN researchers! 🎥 What role does microfluidics play in nanobody discovery? In this interview, Alar Ainla from @INLnano explains how microfluidic technologies & multidisciplinary collaboration help tackle complex challenges like cancer. youtube.com/watch?v=8jpAiLfz…

Harnessing synthetic biology for cancer therapy 🔬 A review by researchers from @CNB_CSIC highlights how engineered bacteria can be programmed to deliver therapeutic molecules directly to tumours and enhance anti-tumour immune responses. @lafdez_synbio sciencedirect.com/science/ar…