Diamond/Southampton PhD Student developing novel approaches for time-resolved structural biology 🔬💎 UEA MSci Biochemistry graduate
Norwich, England
Joined March 2016
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My first 1st author paper is now published - Droplet microfluidics for time-resolved serial crystallography @unisouthampton @serialstubbs @SoCoBioDtp @DiamondLightSou @esrfsynchrotron @sotonbiosci @IUCrJ #DropletMicrofluidics #Micromixing doi.org/10.1107/S20522525240…
🔬 Want to learn serial crystallography by actually doing it?
SSX Hands-On Workshop at MicroMAX 🇸🇪
📅 14–16 Sept 2026
💎 Sample prep → delivery → data collection → analysis
✅ Free registration
⏰ Register by 31 Aug, 12:00
👉 indico.maxiv.lu.se/event/595…
Please share!🧬
Jack Stubbs retweeted
Jack Stubbs et al.: Automated microbatch-under-oil phase diagrams to rationalize serial crystallography sample preparation #SerialCrystallography #SamplePreparation #PhaseDiagrams @unisouthampton @uniofexeter... #IUCr journals.iucr.org/paper?S205…
I'm excited to share my PhD research, now published in @IUCrJ: "Automated microbatch-under-oil phase diagrams to rationalize serial crystallography sample preparation" 💎🔬✨
doi.org/10.1107/S20522525260…
In serial crystallography, the biggest bottleneck is preparing the crystals!
Huge thanks to @CourtneyLendon & @DougInstruments for hosting my @SoCoBio_DTP PIPS placement, where most of this work happened! 🎓
This approach turns sample prep from an art into a rational science for XFELs and 4th-gen synchrotrons.
By using a "diagonal sampling" strategy under oil, we: ✅ Identified complex, non-classical phase boundaries.
✅ Used automated seeding to rescue "nucleation-limited" systems.
✅ Decoupled nucleation from growth to control crystal size and morphology.
Transitioning from a single "hit" to a high-density suspension of uniform microcrystals is often a slow, empirical process of trial and error.
In this paper, we introduce an automated workflow that uses as little as 15–60 µL of protein to map entire phase diagrams. 📈
It's official: I'm (almost) a Doctor! 🎓
I am delighted to announce that I have successfully defended my doctoral thesis and passed my viva voce examination with minor corrections!
A huge thank you to my examiners Andrew Lawrence and Andrew Hudson for a great discussion 🤓
Gave my final PhD talk at the South West Structural Biology Conference on Monday @SussexUni what a ride!
Grateful for the brilliant minds & lively chats. Time to crystallise the thesis! 💎🔬 @unisouthampton @SoCoBioDtp @DiamondLightSou @DougInstruments @sotonbiosci
Go check out some of the experiments I did during my PIPS placement 💎🔬 @DougInstruments @SoCoBioDtp @BBSRC @unisouthampton
Visit our booth and poster presentation at the #ACA2025 meeting.
Pick up a free microseeding toolkit and find out about our new automatic phase diagram optimization experiments. #Crystals #ProteinCrystallization #Microseeding
Click below to see a preview PDF of our poster and be sure to stop by to discuss the methods and results in more detail. douglas.co.uk/posters/Poster…
Jack Stubbs retweeted
Our Faculty Inaugural Lecture Series has showcased the careers of some of our newly promoted Professors. Prof. Ivo Tews delivered an engaging lecture on Protein Crystallography: A Journey into Time and Space.
Watch here 👇 youtu.be/La98j80b_fo
Huge thanks to Sam Dickenson @HennikerPlasma for installing the Plasma HPT-500, a powerful addition to our microfluidic setup @RCatHarwell @DiamondLightSou
This system will allow treatment and bonding of PDMS microfluidic devices for time resolved serial crystallography 💎🔬
Jack Stubbs retweeted
Dominik Oberthür: Microcrystals in structural biology: small samples, big insights ... #IUCr journals.iucr.org/paper?S205…
A true honour to chair the keynote talk from 2017 Nobel Prize laureate Richard Henderson at the annual @SoCoBioDtp research conference @unisouthampton @sotonbiosci
Jack Stubbs retweeted
📍 At the BCA Conference this week? Pop by and say hi to Stefan from DI
He’ll be happy to chat about all things protein crystallization — and why our Oryx robots are a game-changer for rapid phase diagram setup 🔬✨
💻 Can’t make it? Join our webinar on 7th May for a live demo! eventbrite.co.uk/e/sample-pr…
📩 [email protected]
🎥 Sneak peek: youtu.be/AOy3UalgMcY
#BCA2025 #crystallography #structuralbiology #proteincrystallization #microseeding #phaseDiagrams
Jack Stubbs retweeted
🎉Missed our webinar on protein crystallization & phase diagrams? We’re running it again!
📅 7th May 2025
🕚 11:00am (GMT+1)
🔬 Learn how Oryx robots optimise crystallization workflows with speed and precision.
👉 Register now: eventbrite.co.uk/e/sample-pr…
#StructuralBiology #ProteinCrystallization #PhaseDiagrams
Jack Stubbs retweeted
Courtney J. Tremlett et al.: Small but mighty: the power of microcrystals in structural biology #Microcrystals #MicroED #SerialCrystallography @uniofexeter @unisouthampton... #IUCr journals.iucr.org/paper?S205…
Check out the review paper I wrote with @CourtneyLendon addressing methods of matching microcrystal preparation and sample delivery now published in @IUCrJ @SoCoBioDtp @DiamondLightSou @unisouthampton @sotonbiosci @DougInstruments doi.org/10.1107/S20522525250…
Jack Stubbs retweeted
Pls RT 🚨I'm looking for someone excited about #proteindesign and #synbio to join my lab @durham_uni and the @CPBM_heddlelab to undertake a PhD using #synthetic knottins as novel #bioinsecticides. If you're interested please get in touch and check out the advert below 👇
My final @ccp4_mx study weekend as a PhD student 💎💎 @unisouthampton @sotonbiosci @SoCoBioDtp @DiamondLightSou @DougInstruments
