Clinical Associate Professor, Microbiology, HKU. Clinical virologist. Emerging infections: rat hepatitis E and others. Pro-natural intelligence.

Hong Kong
Joined July 2009
Reading Anthropic’s comments on AI posing an existential risk to humanity and all I can think of is this. #iykyk
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Dr Siddharth Sridhar retweeted
📑 Molnupiravir is effective against hepatitis E virus infection in an animal model‼️🦠 #OpenAccess #LiverX journals.lww.com/hepcomm/ful…
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I am a member of the Norwegian Nobel Committee. There are five of us. Five people, appointed by a parliament most of the planet could not find on a map, who decide, once a year, which human being the world has agreed to call good. I know. I know. I think about it on the tram. We meet in a building on Henrik Ibsens gate, a street named after a man who wrote almost exclusively about people discovering they are frauds, which nobody on the committee finds funny except me. There is a room with a long table and the portraits of the dead laureates looking down, Mandela, the Dalai Lama, a great many earnest men in spectacles, and one portrait we do not discuss, which is Kissinger, 1973, awarded while the bombs were still falling, after which two of our predecessors resigned and the satirist Tom Lehrer said political satire was now obsolete. We keep him on the wall. A reminder. Every family has the uncle. It is October in Oslo, which means the sun gives up around four in the afternoon like a civil servant, and it rains the particular Norwegian rain that isn’t quite falling, just hanging there, judging you. I arrive with wet shoes. I always arrive with wet shoes. There is coffee, because this is Norway and there is always coffee, we drink more of it per person than almost anyone alive, and someone’s wife has sent kanelboller, the cinnamon buns, and we sit, five Norwegians, damp, caffeinated, sugared, and we decide the moral standing of the entire species. Let me tell you how it actually works, because the world imagines a cathedral and it is, I promise you, a book club with a mandate. 287 nominations this year. 208 people, 79 organizations. Anyone can nominate, that’s the secret nobody understands: a professor, a parliamentarian, a former laureate, so the “nominee” list is meaningless, it’s a suggestion box, and every autumn some congressman nominates his own golden retriever and the press writes “SHORTLISTED.” Nobody is shortlisted. There is no short list the public ever sees. There is us, and the coffee, and the rain, and the portraits, and a Norwegian stubbornness that is older than the prize itself. We read reports. The institute’s advisers write them, thick dull documents, and we argue. Our chairman told the BBC once that in the final meeting “there is a high temperature.” High temperature, for a Norwegian, means someone slightly raised an eyebrow and then apologized for it. We don’t do high temperature. We do a long silence, and then Kristin says “well,” and everyone knows exactly what “well” meant, and it’s settled. That’s our shouting. “Well.” You’d have to be raised here to hear the violence in it. Now. This year. I will not say the name, because we never say the name, but you know the name. A certain head of state wanted this prize the way a child wants a thing in a shop window, which is to say loudly, and in public, and with the full belief that wanting it was itself the argument. He said he deserved it. He said he’d ended eight wars, a number that grew most times he said it, like a fish. He had other heads of state phone us. Israel’s prime minister posted it on the internet, “Give him the Nobel.” The leaders of Cambodia and Pakistan announced they’d nominated him, as though announcing it were part of it, as though we tally mentions. A man flew around the globe collecting endorsements for a Norwegian committee the way you’d collect signatures for a petition to the council about a noisy dog. And here, uff da, is the detail I treasure, the one that makes me smile into my coffee. The nomination deadline is the 31st of January. He took office on the 20th. So for all the phone calls, all the posts, all the gilded lobbying, the only nominations that could possibly count for this year’s prize were filed in the first eleven days of his term, before he had, by his own arithmetic, ended a single one of the eight wars. He campaigned all year for a prize whose window had shut while he was still hanging up his coat. We didn’t have to reject him. The calendar did. We just watched. Norwegians are very good at watching. We have long winters. People think we sit there weighing his deeds. We don’t. That’s the thing I can’t make the world understand. We’re not grading his homework. We don’t owe anyone the prize for a ceasefire, however real, however loud the announcement. “He made peace” is not a sentence that ends in a medal, the way he believes it does, the way he believes every good thing ends in his name on it. The will of a dead Swede says the prize goes to whoever did the most for fraternity between nations. A dead Swede, I should add, who made his entire fortune inventing dynamite and selling arms, and spent his last years horrified at his own obituary, which called him a merchant of death, and so bought his way to immortality as a man of peace. The whole prize is one guilty arms dealer’s attempt to launder his name. We are, all of us, administering a dead man’s public relations. I find this clarifying. It keeps me humble. It should keep everyone humble, and it keeps, by my count, no one humble at all. So who did we give it to? An eighty-five-year-old woman. A judge. Born in Durban, under apartheid, granddaughter of a Tamil man who came to South Africa as indentured labor, a bus driver’s daughter from the poor Indian quarter, who became the first non-white woman to run a law practice in her province, who defended Mandela’s people when defending them was dangerous, who sat on the Rwanda tribunal and the court at the Hague, and who, at eighty-five, is right now a judge weighing whether a genocide is a genocide. When we told the world, our chairman said the rule of law “underpins the system we have set up to ensure peace,” and that “peace requires justice.” She wasn’t even in Oslo. She was in Nuremberg. In courtroom 600. The actual room where they tried the Nazis. You cannot stage that. God staged that, and God, it turns out, is a better satirist than any of us. She did not phone us. She did not post. No prime minister demanded it for her on the internet. She had, as far as our deliberations are concerned, the one qualification the loud man could never manufacture, which is that she wanted the work and not the medal. The medal finds those people. It flees the ones who chase it. This is not a rule we wrote. It’s just the only pattern the hundred-odd years of our mistakes has ever shown. The reaction from across the ocean was immediate. His spokesman posted that we “place politics over peace.” Ja. Perhaps. We’re five damp pensioners in a rainy city; of course it’s political, it was always political, it was political when we gave it to a sitting American president nine months into his first term for the promise of things he had not yet done, and we have been quietly embarrassed about that one for fifteen years, so believe me, we had a particular reason this year to prefer a woman with fifty years of verdicts behind her over a man with eight wars in front of him and a deadline already behind him. Here is what he will never understand, the thing I’d tell him on the tram if he ever took one. We are the one prize he cannot buy, cannot post his way to, cannot have a friendly dictator phone in for him. Not because we’re incorruptible, nei, we’re as vain and wrong and human as the portraits on our wall. But because the entire point of the thing, the only power a small cold country’s book club has ever held, is that it goes to the person not performing the wanting. The moment you demand it, you’ve proven you don’t understand what it’s for, and proving that is itself the disqualification. He ran the most expensive campaign in the history of the prize and the campaign was the reason. He was never losing to Navi Pillay. He was losing to the concept. It’s dark now. Four o’clock dark. The buns are gone. Kristin said “well” an hour ago and we all went home. I’m on the tram with my wet shoes, and somewhere across the water a very powerful man is explaining to a camera that the prize is rigged, that we’re corrupt, that he’ll win it next year, and he genuinely might, we’re only five idiots and we’ve been wrong before, Kissinger is still on the wall. But not this year. This year an old woman in Nuremberg, in the room where the law once stared down the exact kind of man who thinks wanting a thing loudly enough should make it his, got a phone call she didn’t ask for. That’s the job. We don’t reward the man who ends the war and announces it. We reward the woman who spent fifty years deciding what a war was. He’ll never see the difference. That’s rather the whole point of him. Takk for i dag. I have to change trams.
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Hong Kong syphilis is no laughing matter.
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No, we are not about to have a plague outbreak in Hong Kong.
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Was in Europe for a conference. Good to hear almost nothing on AI, machine learning and robotics for a change. And nobody used AI-generated PowerPoints that are super ugly and hard to read.
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The MH1 Creative Work Presentation, a flagship event of the Medical Humanities I programme, took place on April 9, 2026, showcasing the humanistic dimension of medicine as envisioned by our MBBS I students. This year, we featured a wide range of creative works in diverse formats- for example, videos, physical artwork, storybook, traditional paper cutting, interactive games and websites, and even mosaic artwork. While presented in different forms, these works not only highlight artistic and creative talents but also emphasize the humanistic values essential to medical professionals. 👉 For more details about the Creative Work Presentation, visit: mehu.hku.hk/25-26-mh_cwp/ The Medical Humanities Curriculum is a six-year, compulsory longitudinal programme designed to shape MBBS students into compassionate healthcare professionals. Students are encouraged to embrace five key themes to embody attitudes and behaviours grounded in medical humanities for impactful clinical practice. The five themes are (i) doctor & patient identities; (ii) living & dying; (iii) culture & care; (iv) history of medicine and (v) social justice & humanitarianism. @hku_mehu @hkumed @HKUniversity #MEHU #MedicalHumanities #MH #MedicalEducation #CreativeWorkPresentation
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In May, we were delighted to host the inaugural Annual Forum on Medical Humanities Education and Teacher Appreciation Dinner. It was an honour to welcome so many colleagues, community partners, and students who are passionate about medical education and who came together to deepen their understanding of #MEHU and the Medical Humanities (MH) Programme, while fostering dialogue among stakeholders to further enhance medical humanities education at #HKUMed. We were honoured to have Prof Audrey Shafer from the Stanford University School of Medicine (@StanfordMed) deliver the keynote lecture, "Said and Unsaid: Poetry and Medicine." In addition, our Director, Prof Julie Chen, highlighted the development of our unit and the MH programme, while Dr Nicolette Ray introduced the creative works produced by MBBS Year 1 students. We also presented certificates to the Student Associates of #MEHU in recognition of their exceptional commitment to advancing medical ethics and humanities. Furthermore, we invited Ethos, an award-winning platform dedicated to exploring the human side of healthcare, to showcase its outstanding work to our guests. Once again, we would like to express our heartfelt appreciation to all participants in the inaugural forum. We greatly value everyone's support and look forward to continuing our collaborative efforts to advance medical humanities education. For more details about the event, please visit: mehu.hku.hk/annual-forum-on-… P.S. The HKU Medical Ethics and Humanities Unit is immensely grateful for a generous donation from an anonymous donor in appreciation of the exceptional teachers in the MBBS Medical Humanities (MH) programme, who also wished to specifically recognize our Director, Prof Julie Chen, for her leadership and longstanding contributions to medical humanities education. @hku_mehu @hkumed @HKUniversity @StanfordMed @StanfordMedMuse #MEHU #AnnualForumOnMedicalHumanitiesEducation #MedicalHumanities #MedicalHumanitiesEducation #MedicalEducation
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Dr Siddharth Sridhar retweeted
Who should be tested for hepatitis E? When should treatment be considered? And how should chronic infection be managed in immunosuppressed patients? In the latest #TalkLiverToMe, experts bring perspectives from Europe and Asia to discuss practical approaches to acute and chronic hepatitis E. Listen on EASL Campus: easlcampus.eu/tltm/episode-1… Apple Podcasts: podcasts.apple.com/us/podcas… Spotify: open.spotify.com/episode/67J…
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Hepatitis E is not the same everywhere. In this week's episode of #TalkLiverToMe, experts from Europe and Asia share practical perspectives on who to test, when to treat, and how to manage acute and chronic hepatitis E. Out this Wednesday on EASL Campus, Spotify and Apple Podcasts! More info: easl.eu/event/global-updates…
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Main contribution of DOOR has been enabling metaphors in study titles. Time to close the door on this? Great read. What's Behind DOOR Number 2? Recent Applications From Post-Hoc Analyses of Infectious Diseases Randomized Clinical Trials academic.oup.com/ofid/articl…
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Original Article: Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia (SNAP trial) nej.md/4vL0M6m
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I really feel sorry for the next generation of doctors having to work through scores of people coming in to work up completely benign lesions detected in these ‘spas’.
Announcing a new division of Midjourney called "Midjourney Medical"
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If you really need to go to or near shops selling live poultry, don’t take infants and young children along. They appear more likely to develop symptomatic H9N2 infection. Although most symptomatic H9N2 human infections so far have been mild, the fewer human infections, the better.
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Feels like my building security guard + concierge force quadruples during CNY 🧧
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Our new paper examining eight years of rat hepatitis E surveillance in Hong Kong. 22 cases and a disproportionate impact on immunocompromised persons. www-sciencedirect-com.eproxy…
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This paper also details the largest sero-surveillance study on rat hepatitis E in a human population to date. 0.7% of 8294 tested individuals carried antibodies against rat hepatitis E.
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Finally, we documented an odd split between rat hep E in rats and humans. Although two subtypes circulated in local rodents during the study period, only one made the zoonotic jump to humans. Determinants uncertain.
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