@sonyahans
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Research Scientist @FlatironInst | biological temperature sensors 🌡️ cryo-EM 🔬computational biophysics 👩🏼💻 https://xitter.cf/t.co/5fO6ikXBZo
Joined August 2010
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We’re hiring! Join the Structural & Molecular Biophysics team as a Flatiron Research Fellow. 🔬✨ Experience in cryo-EM methods development or MD simulations of ion channels of special interest.
Apply 👉 apply.interfolio.com/194662
#CryoEM #MolecularDynamics #Biophysics #PostdocJobs
Super excited to have this preprint lead by @jayrshenoy out for people to see! Exciting work!
AlphaFold-based models like Boltz-2 and BioEmu train on atomic conformational structures in order to predict protein dynamics. But is it possible to train these models directly on cryo-EM map ensembles, harnessing conformational data that is typically not deposited in the PDB?
Introducing CryoSampler: a new approach for fine-tuning Boltz-2 with raw supervision on cryo-EM map ensembles.
1/6🧵
Sonya retweeted
AlphaFold-based models like Boltz-2 and BioEmu train on atomic conformational structures in order to predict protein dynamics. But is it possible to train these models directly on cryo-EM map ensembles, harnessing conformational data that is typically not deposited in the PDB?
Introducing CryoSampler: a new approach for fine-tuning Boltz-2 with raw supervision on cryo-EM map ensembles.
1/6🧵
Sonya retweeted
Super proud of @PolymathicAI 's new foundation model on biomolecules! 🚀
It was probably the most challenging datasets 💪 we have gathered so far (which we are making public!) and realizing biology is super hard even when you work with the best domain scientists @PilarCossio2 @sonyahans @JonesyLab & @OlgaTroyanskaya
Hats off to the team led by @SiavashGolkar J.Kovalic
@irina_espejo , @samsledzieski & @mhli41 !
Postdoc job opening! This is a unique opportunity to work at the intersection of computation of experiment between us at the Flatiron and a time-resolved cryo-EM lab at the Crick: crick.wd3.myworkdayjobs.com/… Deadline May 6.
Sonya retweeted
Celebrating #BiophysicsWeek T&C partnered with Phase Space Invaders podcast: Robert Best @sonyahans @XuhuiHuangChem
and host @MiWieczor
Episode 32: Driving the Future of Biophysics: What’s Next in Theory and Computation? buzzsprout.com/2313153/episo…
Sonya retweeted
If you're not on the multi-thousand-person cryo-EM listservs... we (EZ lab @PrincetonCS, @FlatironInst, #CCPEM) just announced a new #heterogeneity challenge for cryo-EM! #CAHRA2025
Webinar this Fri Nov 14 at 12p ET. Datasets and more info here: heterogeneity.notion.site/ch…
We've been preparing this challenge for over a year 🥵 (designing the heterogeneity, collecting data, validating results and metrics). Super excited to finally share it with the community!
There are three mystery❓❔❓ datasets! Some fun facts about each:
1) comp-het: an experimental dataset containing a mixture of mystery❔complexes
2) conf-het: we're asking folks to submit *atomic models* instead of density maps for the first time ❗️❕
3) pose-entanglement: a simple dataset to test how much the pose distribution influences conformation estimation 🐎
Huge shoutout to the members of my group driving this work @FeathersRyan and Robert Heeter, @sonyahans + @PilarCossio2's groups @FlatironInst, and Joel Greer from Tom Burnley's group at #CCPEM.
Calling both methods developers and users to participate! Check out our website for more details!
Announcing cryo-EM heterogeneity challenge #2, now dubbed the 2025 Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms (CAHRA)! Join us for a webinar next Friday (Nov 14th) to learn more. Datasets already posted here: heterogeneity.notion.site/ch…
Sonya retweeted
Last week, #FlatironCCM and #FlatironCCB held a Computational Cryo-EM Workshop that focused on methods for 3D heterogeneity analysis including deep learning and statistical techniques in cryo-EM. #science #biology #math
ALT Large group of people pose for a group photo in an auditorium
Sonya retweeted
Check out our latest preprint for the first community #cryoEM heterogeneity challenge 🎆🎇 @sonyahans @miroastore + method developers and participants!
That's a wrap! The results of the first #cryoEM heterogeneity challenge are up on biorxiv!
biorxiv.org/content/10.1101/…
Sonya retweeted
That's a wrap! The results of the first #cryoEM heterogeneity challenge are up on biorxiv!
biorxiv.org/content/10.1101/…
Sonya retweeted
Interested in pursuing graduate studies in Biophysics at U-M? We're inviting prospective students to explore our program hands-on!
We're now accepting applications for the Biophysics Graduate Preview Program on October 23-24, 2025.📅
Learn more & apply: lsa.umich.edu/biophysics/gra…
Sonya retweeted
Come work with us on advancing science using LLMs! Exciting times ahead 🧑🔬🤖
We are expanding our efforts in LLM-based scientific discovery and are hiring for several roles. Come join my team and work with us on the future of natural language scientific AI!
job-boards.greenhouse.io/dee…
job-boards.greenhouse.io/dee…
See RS and RE roles above.
Sonya retweeted
📣 Calling all Rising Stars in Biological Engineering. Nominate someone or self nominate: forms.gle/EszC1AvRFpfN1G6B8
Sonya retweeted
Registration is now open for our Benzon Symposium on "Protein structure prediction and design"
Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and will feature an amazing list of speakers
Get your application in before March 31st!
ALT Flyer for the conference. Confirmed invited speakers include: Gabriel J. Rocklin Birte Höcker Amy E. Keating Tanja Kortemme Bruno Correia Sarel J. Fleishman Ashutosh Chilkoti Minkyung Baek Noelia Ferruz James S. Fraser Alan M. Moses Susan Marqusee Ben Lehner Mohammed AlQuraishi Dek Woolfson Gustav Oberdorfer Hannah K. Wayment-Steele Ora Schueler-Furman Jennifer Listgarten Alexander Rives Massimiliano Bonomi Debora S. Marks Gaurav Bhardwaj
📣 Save the dates 📅
We are organizing a Benzon Symposium on "Protein structure prediction and design" with what I think is an amazing set of speakers
Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and abstract submission will open in March
ALT Flyer for a Benzon Symposium on Protein structure prediction and design in biology and pharmacology (Sept. 1–4, 2025). Speakers include: Gabriel Rocklin, Birte Höcker, Amy Keating, Tanja Kortemme, Bruno Correia, Sarel Fleishman, Ashutosh Chilkoti, Minkyung Baek, Noelia Ferruz, James Fraser, Alan Moses, Susan Marqusee, Ben Lehner, Mohammed AlQuraishi, Dek Woolfson, Gustav Oberdorfer, Hannah Wayment-Steele, Ora Schueler-Furman, Jenifer Listgarten, Alexander Rives, & Max Bonomi.
We are hiring a Flatiron Research Fellow in the Structural Molecular Biophysics team! Experience with cryoEM and/or membrane protein simulations are a plus! Happy to chat in person with anyone at #bps2025 ! apply.interfolio.com/160227
Excited for #bps2025! Check out what SMBp has been up to at these talks and posters! (Also follow me at the other place.) @miroastore @samsledzieski @a_anand_ojha
Sonya retweeted
we're ~hiring~
@arcadiascience is looking for creative, rigorous, independent scientists interested in being the first person to do a thing. as a plus, you'd get to join our pastry-fueled preprint comment parties, like today :)
jobs.lever.co/arcadiascience…
ALT delicious pastries in arcadia's HQ