Lecturer in Chemistry @chemistryatyork. Designing new bioconjugates and biomaterials for tissue repair.
York, England
Joined April 2017
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Our latest paper from Lydia and @XeniaKSS is out in JACS Au! We wanted better reagents for selectively labelling protein N-termini, so looked at how functionalisation affected each step of the complex equilibrium, leading to faster and more stable probes!
pubs.acs.org/doi/10.1021/jac…
Chris Spicer retweeted
Keep an eye out for the last couple from the group!😎🦾
Latest instalment: Phathu’s PhD work on enantioselective a-amination just out in @JOC_OL (pubs.acs.org/doi/10.1021/acs…). Congrats to Phathu and the entire team!🎉🎉 For more from this guy, keep an eye out on the @spicerlab!
Our latest preprint is out - Lydia took a deep dive into the chemistry of pyridinecarboxaldehydes to try and find improved reagents for labelling protein N-termini. Spoiler: we think we found some design criteria that allow us to achieve just that!
chemrxiv.org/engage/chemrxiv…
Chris Spicer retweeted
Hi! I am excited to share a new paper led by @RozansSam We all love peptides and put them in biomaterials, but don't often think about how stable they are during culture. Sam and co-workers synthesized a series of peptide libraries and incubated them with different cell types.
New preprint, where we use functionalised peptides as catalysts for proximity labelling of proteins - with the ability to screen libraries of peptides for protein binding, we think this could be a really versatile tool for site-selective modification.
chemrxiv.org/engage/chemrxiv…
Lovely day out on the North Yorkshire coast yesterday to say goodbye to our fantastic Mchem students Perisa and Alicia. Best of luck for your next steps!
Our group had a fantastic time showcasing hydrogel chemistry (beautiful alginate beads and 'fake snow'!) to the next generation of budding scientists at @YorkFestofIdeas last week, along with the team of @professor_dave and @YBRI_UoY. Great to interact with the York community
Make your way to Acomb Library today to have a go at making your own hydrogel and learn how they are used in medicine!
#getinvolved #science #outreach @YorkFestofIdeas
Chris Spicer retweeted
Mixed feelings to announce the first paper to come out from our good friend Prof Paul Clarke's lab since he died last year. Elegant and creative total synthesis work of the type Paul was always best known for.
@ChemistryatYork @ChemCommun @Ian_Fairlamb
pubs.rsc.org/en/Content/Arti…
Chris Spicer retweeted
#NewPaper from @spicerlab and colleagues @ChemistryatYork
'Expanding the scope of the successive ring expansion strategy for macrocycle and medium-sized ring synthesis: unreactive and reactive lactams' #antibacterial #assays #ecoli
pubs.rsc.org/en/content/arti…
Nice to be able to play a small role in supporting the work of good friends of the group in 2 papers this week. The first led by @theSeriousLab with @XeniaKSS just out in PLOS Biology on microfabrication platforms for cell culture
journals.plos.org/plosbiolog…
#NewPaper from @spicerlab and colleagues @ChemistryatYork
Low-cost, versatile, and highly reproducible microfabrication pipeline to generate 3D-printed customised cell culture devices with complex designs #cellculture #bioengineering
journals.plos.org/plosbiolog…
And the second led by @UnsworthChem and his team expanding their ring expansion chemistry. Big congratulations to PhD student Owen, joint supervised with Will and Martin Fascione @ChemBiolYork on what I'm sure will be the first of many papers!
pubs.rsc.org/en/content/arti…
Also 2 new entries for journal bingo, which I know @UnsworthChem will approve of
Chris Spicer retweeted
Strain-Promoted Cycloadditions in Lipid Bilayers Triggered by Liposome Fusion (Molly M. Stevens and co-workers) @imperialcollege #OpenAccess onlinelibrary.wiley.com/doi/…
Our new paper has been a labour of love so delighted to see it out! We show that strain-promoted cycloadditions can take place in lipid membranes, providing a potentially valuable tool to study membrane proteins, lipid dynamics, and bilayer transport
onlinelibrary.wiley.com/doi/…
Congratulations to the group's second PhD student Laetitia on her graduation last week! The first one I've been able to attend at @ChemistryatYork so a very proud supervisor moment, and lovely to see some of our undergrad students back to celebrate as well
Great work from @ChemBiolYork PhD Abby from the Fascione group! Must read for glyco scientists
Absolutely delighted that my first first author paper has been published in @angew_chem! We've identified the founding member of a previously unreported glycosyltransferase family (GT118); a retaining pseudaminyltransferase, KpsS1, from A. baumannii ACICU! onlinelibrary.wiley.com/doi/…
Chris Spicer retweeted
We are recruiting! 3 year PDRA in natural product synthesis.
Part of a multidisciplinary natural product biosynthesis project led by @LichmanLab, also with Gideon Grogan. This role is for an organic chemist to work in my lab. Informal inquiries welcome.
jobs.york.ac.uk/vacancy/pdra…
Lovely work from Nick Yates @ChemBiolYork, addressing solubility issues with NHS and sulfo-NHS esters across different solvents - a must read for anyone using these molecules for bioconjugation!
pubs.acs.org/doi/10.1021/acs…
Still time to apply for a PhD with our group and @professor_dave, perfect for people wanting to do synthetic chemistry but with lots of interdisciplinary opportunities to learn more about biology and biomaterials. Deadline 4th Jan
Looking for a #PhD project developing self-healing dynamic hydrogels for biomedical applications? Check out the opportunity below working with @spicerlab and @professor_dave.
📅 Deadline 3 Jan.
More info: bit.ly/475cMmq
#ChemPhD #gelsgelsgels @YSBL_York
Chris Spicer retweeted
Do you hate plastics? We have 2 PhD scholarships in Chemistry at Uni Newcastle looking at destroying them with polymer coated enzymes. Interntional or Domestic. Come join the team! newcastle.edu.au/study/resea…