Human performance, physiology, sports, health, etc. @splsystems on instagram Check out my Substack ⬇️

Joined June 2020
Sean Langan, PhD retweeted
Linkedin is the worst thing ever created.
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Sean Langan, PhD retweeted
I love it when people overcomplicate physiology. It makes my job easier. I agree…what a mess.
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Sean Langan, PhD retweeted
These aren’t the highest rates of fat oxidation ever measured in a human - elite racewalkers who adapted to a keto diet for 6 days or 3.5 weeks showed higher rates - some at 2 g/min. But they raced at a slower speed when asked to perform in a real life race. You can’t outrun the stoichiometry of fuel production. Carbs produce more ATP per litre of oxygen than fat.
A study put elite athletes who burned almost no carbs on a treadmill. They recorded the highest fat-burning rate ever measured in a human. The FASTER study. 2016. Published in Metabolism. Twenty of the best ultra-endurance athletes on earth. Ultramarathoners. Ironman triathletes. The kind of people whose careers depend on knowing exactly what fuel works. They were split into two groups. Ten ate the standard high-carb athlete diet. The diet every sports nutritionist still pushes. Eat the carbs. Load the carbs. You cannot perform without the carbs. Ten had been low-carb and keto-adapted for an average of twenty months. Same elite level. Same competitions. No carbs. Both groups ran three hours on a treadmill. Researchers measured exactly what fuel each body was burning, breath by breath. Here is what they found. The keto group burned fat at 2.3 times the rate of the carb group. Peak fat oxidation hit 1.5 grams per minute. The textbooks said the human body maxes out near 0.7 grams per minute. The keto athletes doubled the supposed limit. The highest fat-burning rate ever measured in a human, full stop. Then the part that should have ended the carb-loading dogma forever. The fear was that without carbs they would run out of muscle glycogen mid-race. They did not. Their glycogen use during the run and their refill afterward matched the carb athletes exactly. They were running on their own fat at elite intensity. With glycogen behaving identically. The body was never carb-dependent. It was carb-trained. You can train it differently. Almost a decade later, every endurance handbook still tells athletes to load up on carbs. The data has been sitting there the whole time.
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Sean Langan, PhD retweeted
“how do I become a better runner?”
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Sean Langan, PhD retweeted
well - try to ingest 120 grams of CHO (with ½ glucose and ½ fructose) and see what happens (just resting)
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Our latest work: "Sprint interval exercise disrupts mitochondrial ultrastructure, driving a unique mitochondrial stress response and remodelling in men" has been accepted in Nature Communications and will soon be online 😊
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Sean Langan, PhD retweeted
This might surprise you about blood testing. One reason it has gotten so much cheaper is that many companies have shifted towards using prediction equations. So those 40, 80, or 120 biomarkers "you're paying to get tested" ....are not actually being measured. This ranges from awful to awesome. E.g., Free testosterone is rarely directly measured. Been like that for decades. Cool. The issue is not all blood testing facilities use the same equation (there are multiple validated ones) - so you might be 'going up' or 'going down' simply because of switching providers. Futhermore, if you ever get direct free test measured, it will likely differ greatly from your predicted values; confusing the crud out of you. Again, nothing new here. What has changed is the expansion to numerous other markers, based heavily (if not entirely) on the company's own algorithm. i.e., NOT on externally validated equations. This becomes a huge issue because: 1. Customers are being deceived (overtly and covertly) 2. The prediction equation can be hugely erroneous, especially if you are outside of the reference population the company used to build it (which we don't know because they haven't externally validated it yet). Obviously, I have a major COI in this space, so interpret that however you will, but people should know this is happening and can make whatever decision with that information they choose. Happy Wednesday!
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Congrats to Sean P. Langan et. al, for the #APSselect paper "Hypoxia-induced impairments in fasting glucose are associated with acute mountain sickness severity during four days of residence at 4,300 m" in @AJPRegu @spl5_ @TeamUSARIEM ow.ly/hCNP50XpsoT
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Sean Langan, PhD retweeted
Consistent with all previous cases, my sleep parameters show full recovery after illness before my standing values. I’m not expressing confusion, I’m highlighting greater sensitivity of standing HRV.
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Before your next mountain weekend, check out this #ResearchArticle from Langan @spl5_ et al: Hypoxia-induced impairments in fasting glucose are associated with acute mountain sickness severity during 4 days of residence at 4,300 m ow.ly/TECe50XmUux
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Sean Langan, PhD retweeted
You’d be much healthier walking 20k steps and eating the 3 Oreos than you would be skipping the Oreos and not walking 20k. (Math is wrong anyway)
Doing 20k steps burns roughly the same calories as not eating 3 Oreos. So you can either walk for 3+ hours daily, or just... not eat 3 Oreos. One requires rearranging your entire life. The other requires basic self-control. Choose your hard.
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Research Article by PA Fabries et al. (@spl5_ @TeamUsariem @UNMHSC @GeiselMed) Active #ascent accelerates the onset of acute #mountainsickness at 4,300 m 🏔️ ow.ly/x5rN50WFgb0
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This is clearly comprehensive and resource-intensive work. However, things become less convincing when we take a closer look at the human data, which were the original basis for identifying increases in betaine as a long-term exercise-induced change.
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Sean Langan, PhD retweeted
How to get huge and turn your aorta into a lead pipe? Overeat and do a lot of heavy lifting.
Hot take: “You can’t out-exercise a bad diet” is kind of BS. If you lift heavy consistently, you can buffer a surprising amount of junk. Is it optimal? No. But lifting is the cheat code for health most people ignore. Diet matters—but exercise is king.
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This week on the #ISpyPhysiology blog, APS member Sean Langan (@spl5_) tells us about #OvertrainingSyndrome and how to avoid it when we exercise: ow.ly/84Vb50VOLqv
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Pump to have this huge field-based athlete methods and logistics review published with amazing co-authors. Includes elements of ethics, planning, checklists and protocols. OPEN ACCESS: rdcu.be/eiECo
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Sean Langan, PhD retweeted
What do you think makes someone “athletic” @spl5_
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Sean Langan, PhD retweeted
If you do not know why being able to put a dot above the V is useful: A) it probably means you have a real life and B) ok, I got nothing, see A.
A cool trick. My birthday is March 7th. If you type 0307 straight after a capital V and hold down the Alt key and press x, the rate dot will automatically appear above the V. So, if you want to put the dot over the V for VO2, remember my birthday and hey presto! You’re welcome ☺️
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Sean Langan, PhD retweeted
How to improve fatigue resistance (i.e. how much VO2max, running economy, etc. worsen during a run)? One new study finds heavy strength training and plyometrics work; another paper suggests cumulative training volume plus a shortcut: supershoes. outsideonline.com/health/tra…
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