How does the clubroot pathogen evolve to overcome crop resistance? A global question needed a global collaboration 🌍🧬 Four years ago, this project started with a simple question: Could we bring isolates from other countries into our lab? Luckily, many colleagues from over 20 countries around the world said yes! Together with Stephen Strelkov and Maxim Prokchorchik, we combined three datasets: 192 isolates from 24 countries and 53 chromosome-level genome assemblies, forming the most comprehensive Plasmodiophora brassicae pangenome to date. This work, led and central to @asimjaved777 (Bravo 🥳! #ProudPI), with major contributions from Florent, Sandra Gomez, @SohamBio, and many more, reveals: 🧬 Clonal expansion alongside genomic evidence of recombination, consistent with sexual reproduction. 🧬 A hotspot of structural variation and ankyrin-repeat effector diversification on chromosome 17. 🧬 Differences in predicted effector structures and host interactions associated with CRa resistance breakdown. And chaperones are back in the spotlight! The identification of co-chaperone DJC31 as a candidate effector target builds on our earlier work highlighting ankyrins as a dominant effector family, targeting host translation machinery (See: elifesciences.org/articles/1…). The main message: even a compact, highly conserved pathogen genome can hold considerable potential for adaptation, with consequences for resistance durability. This effort received essential support through the CARP program by @canolacouncil funded by @AlbertaCanola , @ManitobaCanola, @SaskOilseeds, and @westerngrains. By @RDARAlberta , @NSERC_CRSNG Discovery and Alliance Programs, Génome Québec Programme d’intégration de la génomique, and by @BioplatformsAus / NCRIS. Thank you to everyone who made it possible! The final database and sequences will be publicly available upon manuscript acceptance. Now begin The Hunger Games, a.k.a. The Submission and Revisions Game. 😅 We don’t know where this paper will land, but we are incredibly proud of what we built together. Link to preprint 🔗 : biorxiv.org/content/10.64898…