@sys_sig

@syssig.bsky.social mtDNA, nets, noise, inference | @IX_AI_SciCentre @ImperialX_AI @ImperialMaths

imperial.ac.uk/people/nick.jones/research.html
Joined October 2020
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Systems and signals group at @ImperialMaths led by Nick Jones. Stay tuned for our latest research on #mitochondria #aging #genetics #biomathematics #physicalbiology #networks and #ML. We blog regularly systems-signals.blogspot.com and there's more info at imperial.ac.uk/people/nick.j…
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Our paper 'Cryptic mitochondrial DNA mutations coincide with mid-late life and are pathophysiologically informative in single cells across tissues and species' nature.com/articles/s41467-0… now out in Nature Communications. See our thread on bsky

Cryptic mitochondrial DNA mutations coincide with mid-late life and are pathophysiologically...

Nature Communications - Mitochondrial dysfunction is implicated in ageing. Here the authors report that across tissues and species, somatic mitochondrial DNA mutations in single cells (termed...

nature.com
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We will begin the switch over to other social media and have a blueskye account @syssig.bsky.social
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We decided to readvertise our exciting paper 'Cryptic mitochondrial ageing coincides with mid-late life and is pathophysiologically informative in single cells across tissues and species' 1/6 biorxiv.org/content/10.1101/…
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Over 7 datasets, in multiple tissues in humans, mice and rats, cells with cryptic mtDNA mutations have gene expression changes consonant with ageing including immune effects and protein misfolding. We give experimental corroboration in human cell lines. 5/6
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Calorie restriction (CR) is known to improve healthy ageing and we find indications that CR rats have lowered levels of cryptic mtDNA mutations. CR can increase mtDNA numbers and our theory predicts that higher mtDNA copy-numbers slow accumulation of mtDNA mutations. 6/6
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Systems and Signals retweeted
I-X@ImperialX_AI23 Jul 2024
🌟 Six 4-year Independent Fellowships dedicated to AI in Science in a program supported by Schmidt Sciences and Imperial College London (offered through @imperialcollege Research Fellowships). 🗓 Deadline: 19 August 🔗 Read about the fellowships ➡ imperial.ac.uk/news/255057/i… 3/3

Imperial will recruit 16 fellows in artificial intelligence | Imperial News | Imperial College...

The I-X Centre for AI in Science has just announced sixteen fellowships in AI in Science.

imperial.ac.uk
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Systems and Signals retweeted
I-X@ImperialX_AI23 Jul 2024
🌟 Ten 2-year Independent Fellowships dedicated to AI in Science in a program supported by @schmidtsciences: ➡ Eight 2-year Eric and Wendy Schmidt AI in Science Postdoctoral Fellowships. ➡ Two 2-year Chapman Schmidt Fellowships. 🗓 Deadline: 20 September 2/3
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Systems and Signals retweeted
I-X@ImperialX_AI23 Jul 2024
📢 Job Alert: 16 Independent Fellowships in AI in Science! The @IX_AI_SciCentre seeks 16 new fellows to join their prestigious programme and accelerate artificial intelligence research in Engineering, Natural and Mathematical Sciences. How to apply: imperial.ac.uk/ix-ai-in-scie… 1/3
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A fun video introducing I-X youtu.be/8dy-ah70f_E?si=LEh0… @ImperialX_AI @IX_AI_SciCentre
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Please circulate: new I-X lectureship in I-X and Imperial Statistics: imperial.ac.uk/jobs/descript… @ImperialX_AI learn about I-X here ix.imperial.ac.uk/
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Systems and Signals retweeted
Ben Fulcher@bendfulcher25 Sep 2023
Work by @olivercliff @AnnieGBryant @NaoTsuchiya @jlizier published today in @NatComputSci ! Article link: nature.com/articles/s43588-0… And thanks to @jkbren for a really clear and thoughtful commentary: nature.com/articles/s43588-0…

Unifying pairwise interactions in complex dynamics

Nature Computational Science - This work unifies an interdisciplinary literature of over 230 computational methods for measuring interactions from complex systems, revealing previously unreported...

nature.com
Ben Fulcher@bendfulcher31 Jan 2022
New preprint! @olivercliff w/ @NaoTsuchiya @jlizier: "Unifying Pairwise Interactions in Complex Dynamics". Want to quantify the relationship between two time series? We compared over 249 pairwise dependence measures on >1000 multivariate time series 😮 arxiv.org/abs/2201.11941
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Work by @FerdinandoInsa1 on boosters for COVID19 versus Delta/Omicron, with great @UKHSA collaborators. journalofinfection.com/artic… Boosters work, but protection wanes in ~4 months highlighting the need for continuous monitoring of vulnerable people and for correlates of protection.

Effectiveness of BNT162b2 mRNA vaccine third doses and previous infection in protecting against...

Third doses of COVID-19 vaccines were widely deployed following the primary vaccine course waning and the emergence of the Omicron-variant. We investigated protection from third-dose vaccines and...

journalofinfection.com
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Systems and Signals retweeted
I-X@ImperialX_AI6 Oct 2023
📌JOB VACANCY: Senior Teaching Fellow We are looking for a Senior Teaching Fellow who will have a key role in the training of the @IX_AI_SciCentre Fellows and developing our educational programmes within I-X. Deadline: 26 Oct Apply below⬇️ imperial.ac.uk/jobs/descript…
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Systems and Signals retweeted
I-X@ImperialX_AI7 Aug 2023
📢11 new independent Fellowships in #AI in #science are now open for applications👏 Don't miss out on this fantastic opportunity to be at the forefront of @imperialcollege #AIresearch 🤖 ⬇️Find out more & apply imperial.ac.uk/ix-ai-in-scie… @ImperialAI @ImperialDSI @ImperialSci
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Replying to @IX_AI_SciCentre @SchmidtFutures @ImperialX_AI
Coming Soon... Launching in August, there will be a further round of up to 8 two-year #AI in Science #fellowships. These are flexible & independent and you will be joining a cohort of top scholars based in @ImperialX_AI! Keep an eye out here ⬇️ ix.imperial.ac.uk/research-c…
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Applications are now open for 3 independent 4-year fellowships dedicated to #AI in Science & supported by @SchmidtFutures Based in @ImperialX_AI, these prestigious Imperial College Research Fellows will be given bespoke training & 121 career development imperial.ac.uk/jobs/descript…
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An exciting AI in Science themed independent fellowship for two years joint between the African Institute of Mathematical Sciences in Kigali and Imperial. @ImperialX_AI @AIMS_Rwanda
I-X@ImperialX_AI5 May 2023
📢Don't miss out on the AI in Science Postdoctoral Fellowship between London & Kigali: based at @imperialcollege in I-X for the first year & @QL_Africa, @AIMS_Rwanda for the second. Support from @SchmidtFutures & @CarnegieCorp Deadline: 31 May @AIMS_Next imperial.ac.uk/jobs/descript…
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