Tabris🌻

2026 is the year capital flows into biotech. 2012 - CRISPR discovered, nobody knows what to do with it 2018 - Gene therapy costs $2M per treatment, completely unscalable 2020 - mRNA works but gets written off as a COVID fluke 2023 - AI eats software, biotech still stuck in 20-year timelines 2024 - Autonomous labs emerge, longevity gets institutional backing 2025 - FDA shifts, manufacturing costs drop 40%, DeSci bypasses gatekeepers 2026 - AI running 36K experiments autonomously, gene therapy costs dropped 40%, FDA fast-tracking, €2.5M crowdfunded in 72 hours, and biology just hit software velocity bio/acc.

There’s no way Ancient China and the Aztec empire both just so happened to come up with almost the exact same idea The only logical explain here is that dragons were real but have been hunted to the point of almost near extinction over the centuries

Alysa Liu recently went viral for her Teen Vogue rant on the history of Renaissance Alchemy. "It was all, in fact, metaphorical," the figure skater said, adding that "it is important to realize that the goal was never gold, but inner transformation"

everyone thinks they know what the AI moats are now: - distribution - "taste" - juicy data moat - hardware but here's what no one is saying: - distribution can be rented (ABG CMO, paid influencers and UGC) - taste can be bought (hire creative agencies, ghost writers) - data can be scraped (or generated) - hardware can be leased / rented the only two real moats left are: 1. trust 2. community you can't buy these two things. you can only earn it slowly, and lose it instantly. the companies that survive AGI aren't the ones with the best model. they're the ones people still believe in when the model gets it wrong.

How it's felt to force myself to get educated in science/engineering instead of majoring in art

Over the past year, many people I talk to have expressed worry about two topics: * Various aspects of the way the world is going: government control and surveillance, wars, corporate power and surveillance, tech enshittification / corposlop, social media becoming a memetic warzone, AI and how it interplays with all of the above... * The brute reality that Ethereum seems to be absent from meaningfully improving the lives of people subject to these things, even on the dimensions we deeply care about (eg. freedom, privacy, security of digital life, community self-organization) It is easy to bond over the first, to commiserate over the fact that beauty and good in the world seems to be receding and darkness advancing, and uncaring powerful people in high places are making this happen. But ultimately, it is easy to acknowledge problems, the hard thing is actually shining a light forward, coming up with a concrete plan that makes the situation better. The second has been weighing heavily on my mind, and on the minds of many of our brightest and most idealistic Ethereans. I personally never felt any upset or fear when political memecoins went on Solana, or various zero-sum gambling applications go on whatever 250 millisecond block chain strikes their fancy. But it *does* weigh on me that, through all of the various low-grade online memetic wars, international overreaches of corporate and government power, and other issues of the last few years, Ethereum has been playing a very limited role in making people's lives better. What *are* the liberating technologies? Starlink is the most obvious one. Locally-running open-weights LLMs are another. Signal is a third. Community Notes is a fourth, tackling the problem from a different angle. One response is to say "stop dreaming big, we need to hunker down and accept that finance is our lane and laser-focus on that". But this is ultimately hollow. Financial freedom and security is critical. But it seems obvious that, while adding a perfectly free and open and sovereign and debasement-proof financial system would fix some things, but it would leave the bulk of our deep worries about the world unaddressed. It's okay for individuals to laser-focus on finance, but we need to be part of some greater whole that has things to say about the other problems too. At the same time, Ethereum cannot fix the world. Ethereum is the "wrong-shaped tool" for that: beyond a certain point, "fixing the world" implies a form of power projection that is more like a centralized political entity than like a decentralized technology community. So what can we do? I think that we in Ethereum should conceptualize ourselves as being part of an ecosystem building "sanctuary technologies": free open-source technologies that let people live, work, talk to each other, manage risk and build wealth, and collaborate on shared goals, in a way that optimizes for robustness to outside pressures. The goal is not to remake the world in Ethereum's image, where all finance is disintermediated, all governance happens through DAOs, and everyone gets a blockchain-based UBI delivered straight to their social-recovery wallet. The goal is the opposite: it's de-totalization. It's to reduce the stakes of the war in heaven by preventing the winner from having total victory (ie. total control over other human beings), and preventing the loser from suffering total defeat. To create digital islands of stability in a chaotic era. To enable interdependence that cannot be weaponized. Ethereum's role is to create "digital space" where different entities can cooperate and interact. Communications channels enable interaction, but communication channels are not "space": they do not let you create single unique objects that canonically represent some social arrangement that changes over time. Money is one important example. Multisigs that can change their members, showing persistence exceeding that of any one person or one public key, are another. Various market and governance structures are a third. There are more. I think now is the time to double down, with greater clarity. Do not try to be Apple or Google, seeing crypto as a tech sector that enables efficiency or shininess. Instead, build our part of the sanctuary tech ecosystem - the "shared digital space with no owner" that enables both open finance and much more. More actively build toward a full-stack ecosystem: both upward to the wallet and application layer (incl AI as interface) and downward to the OS, hardware, even physical/bio security levels. Ultimately, tech is worthless without users. But look for users, both individual and institutional, for whom sanctuary tech is exactly the thing they need. Optimize payments, defi, decentralized social, and other applications precisely for those users, and those goals, which centralized tech will not serve. We have many allies, including many outside of "crypto". It's time we work together with an open mind and move forward.

🚀 Introducing the Qwen 3.5 Small Model Series Qwen3.5-0.8B · Qwen3.5-2B · Qwen3.5-4B · Qwen3.5-9B ✨ More intelligence, less compute. These small models are built on the same Qwen3.5 foundation — native multimodal, improved architecture, scaled RL: • 0.8B / 2B → tiny, fast, great for edge device • 4B → a surprisingly strong multimodal base for lightweight agents • 9B → compact, but already closing the gap with much larger models And yes — we’re also releasing the Base models as well. We hope this better supports research, experimentation, and real-world industrial innovation. Hugging Face: huggingface.co/collections/Q… ModelScope: modelscope.cn/collections/Qw…

My LinkedIn is just the usual stream of company announcements and cringeposts, and then there's George Hotz poisoning the stream with these highly entertaining blackpills: