Nze Nzube Ndiokwelu

Lagos State has unveiled a long-term development plan targeting an economy worth nearly $1 trillion by 2052, as it seeks to attract investment and strengthen its position as a globally competitive economic and financial hub.

And that’s a wrap on the second edition of our AI for Academic Productivity training! Two remarkable days with the Faculty of Health Sciences and Technology, University of Nigeria, Enugu Campus. Once again, the turnout was impressive, with enthusiastic participation across disciplines and interest from senior university leadership. Beyond exploring AI for teaching, research, clinical education and discovering opportunities, some of the most fascinating moments came from the conversations around accuracy, trust and human judgement. One discussion that stayed with me was how technology is changing whom we trust, sometimes placing more confidence in what a screen tells us than in the person standing before us. And just when I thought we were wrapping up, the Faculty surprised me with a plaque of appreciation to The Beaconsmith Collective, presented on behalf of the Dean. I genuinely didn’t see that coming, and it meant a great deal. Grateful to the Faculty, its leadership, our team and everyone who made these two days memorable. Beyond teaching people to use AI, we’re helping them discover what’s possible.w

Over the past few months, Anthropic scientists have engaged in deep research partnerships with six organizations developing new medicines. We've also begun drug discovery efforts of our own. In doing so, we’ve learned much more about how Claude can support the many stages of drug development. In this blog post, we share some early results from these efforts, and describe how this work fits in with our wider ambitions in the life sciences. anthropic.com/research/early…

The drug class we are developing, Claromers, kill nearly all known germs (bacteria, viruses, fungi, and biofilms) with one simple devastating mechanism that has avoided microbial resistance for over 200 million years. Claromers mimic a natural defense peptide in the human body called LL-37. Each Claromer molecule is very small, only dozens of atoms big - about 1/3 the size of the natural peptide. It is like a spear - a destructive end and a holding shaft or tail end. The shaft side is hydrophobic, which means it is water-avoiding and does not like to touch water. The other side - the pathogen destroyer - is highly positively charged (called “cationic” in science literature), like a powerful magnet that pulls toward anything negatively charged (called “anionic” in science). Stanford bioengineering Assoc Prof Barron and colleagues wrote in a recent study of Claromers: “These amphipathic peptoids self-assembled in different ways, as determined by small-angle X-ray scattering; some adopt helical bundles, while others form core−shell ellipsoidal or worm-like micelles.” That means the groups form either short twisted bundles, like worms, or small oval shapes like a football. 🏈 The self-assembly into these nano structures I. the watery fluids of the body because the water-avoiding shaft-tails point inward toward each other , away from the water. The positive pathogen-killer ends stick outward like sharpened spears. The molecules stick together on their own into tight groups. These groups attack like a three-dimensional Greek phalanx, a tight formation of soldiers. Like a football made of spears. The spears face out. Because each molecule is so tiny its mass is almost zero. When the positive killer ends feel the pull of the germ’s outer covering they accelerate from standing still to nearly the speed of light with almost no friction, like lightning bolt ⚡️ leaping towards the pathogen. The killer-football formation hits all at once the with huge kinetic energy and blows apart the outer membrane of the pathogen. The germ cannot survive. It is destroyed in a microsecond. Barron and colleagues also wrote: “While self-assembly correlated overall with antibacterial efficacy... Certain self-assembled morphologies seem better-suited for antibacterial activity.” The football 🏈 hits harder. We choose the super effective oval shapes that mass the spears for the strongest hit.

The Igbo language seeks efficiency and continously underwent reductions for continuities notebook.google.com/notebook…