UltimApe retweeted
Fix the Gut-Lung axis. 🫁🦠
> "This review provides current insights into the interplay between the intestinal microbiota and the immune system, focusing particularly on its intermediary function in vaccine efficacy." [AUG 2024]
pmc.ncbi.nlm.nih.gov/article…
xitter.cf/ultimape/status/160137…
1) Flu vaccine effectiveness mediated by gut bacteria.
med.stanford.edu/news/all-ne…
2) Maternal gut regulate RSV infection risk in children via bacterial strain Lactobacillus johnsonii.
pubmed.ncbi.nlm.nih.gov/3461…
3) Gut Bacteria disrupted due to covid.
nih.gov/news-events/nih-rese…
4) Ergo:
I don't really think about languages trees anyway. I think about it as overlapping Venn diagrams. These can easily decompose into trees, but its loose boundaries are more stochastic and make sense in terms of prediction. So it's kind of a hybrid in my thinking here.
Huge if tru:
Chomsky was wrong.
Researchers found your brain doesn’t store language the way every textbook since 1957 claims.
For decades, the undisputed rule of linguistics, led by Noam Chomsky, was that human language is hierarchical.
We were told our brains process language using complex "grammar trees." That we secretly build deep, abstract, mathematical rules in our heads before we speak.
This new paper proves that is completely wrong.
Researchers at Cornell University analyzed how people actually process and produce language in real time.
They found sequences. Linear chunks.
When we speak, we aren't calculating deep syntactic rules. We are just predicting the next most logical sequence of words based on the context of the words right before it.
We string linear chunks together.
If this sounds familiar, it should.
This is exactly how Large Language Models like ChatGPT work.
For years, critics have dismissed AI as "just a next-token predictor." They said it isn't truly intelligent because it doesn't understand deep grammatical hierarchies like humans do.
But this paper suggests humans don't use those hierarchies either.
We are just predicting the next chunk.
Language isn't a rigid tree of mathematical rules. It's a linear stream of contextual predictions.
We thought we were building AI to mimic the complexity of the human brain.
It turns out, the human brain was just running a simpler algorithm all along.
UltimApe retweeted
For anyone getting into biology, please consider taking airborne disease resistance more seriously.
It's a super important area of medicine that is a huge cause of death and sickness but easily gets forgotten. We're likely to get many more airborne plagues in the future due to the combination of not just extremely dense and interconnected society (including city and farm animals), but also accidents from bio research and offensive biotech (both from random people and from secret government programs that can easily get themselves exempted from safety restrictions), all enhanced by powerful AI.
Right now, this area is getting way less love than longevity research (which continues to be super important!), but it's an area where there are lots of unclaimed wins that we know exactly how to do (but are not yet doing) with present-day tech:
* early detection
* passive universal testing
* filtration/ventilation/UVC
* better vaccines (including making them open source and open science)
* cryptography to make all of the above privacy-preserving
We can have China-level pandemic resistance with Sweden-level limited intrusion into people's lives, and then go even further. We just have to actually do the work for it.
I learned a few days ago that scientists have been testing herbal products wrong and literally destroying the important chemical by heating it.
And today I learned that many of the polyphenol studies are probably mismeasured ala dumb GI models of bioavailability.
興味深いのは、長年科学者たちが類似の植物(クソニンジン)の実験で、熱によりアルテミシニンを破壊していた点です。
屠呦呦(トゥ・ユーユー)氏が葛洪の著作からこのことに気づき、ノーベル賞を受賞しました。
nobelprize.org/stories/women…
I have a freezer full of berries, but the one thing I'm missing is pomegranate.
Asked my girlfriend to find some.
"The positive clinical results on pomegranate and suppression of oral bacteria are intriguing and worthy of further study" [2013] pmc.ncbi.nlm.nih.gov/article…
xitter.cf/macredsmile/status/201…
Mmm berry smoothies.
Replying to @ultimape
Have you tried to get stronger, anon?
Have you tried to avoid scar tissue so your limbs can regenerate?
"Gut bacterial metabolite Urolithin A inhibits myocardial fibrosis through activation of Nrf2 pathway in vitro and in vivo"
molmed.biomedcentral.com/art…
xitter.cf/ultimape/status/163372…
Replying to @ultimape @ekverstania
As I understand it, this is one of the things that @DrTempleGrandin thinks needs more research.
I'd fund you in a heartbeat if I could. I think you're exactly right.
Replying to @ultimape
Saddened to hear even @DrTempleGrandin thinks that aspect is under-researched. But comforting to know I'm not alone.
xitter.cf/ultimape/status/823069…
Oh my it just keeps getting better as I read thru.
"It’s hard to think of a better name for this kind of behavior than what Feynman famously dubbed cargo cult science"
pmc.ncbi.nlm.nih.gov/article…
This is the most brutally critical paper i have ever read
UltimApe retweeted
Can you imagine taking allergy medicine for a few days and your longtime depression or ADHD just goes away? I'd be pissed
This is a small case series of patients with refractory neuropsychiatric disorders such as depression, anxiety, OCD, ADHD and more, who experienced significant improvement after subsequent diagnosis and treatment of MCAS.
While the average person still thinks that histamine for example is just something related to allergies, let’s not forget that histamine acts as a neurotransmitter in the brain, influencing things such as arousal, attention, mood, sleep, and motivation.
So when levels build up it can create:
-Restlessness and physical + mental hyperactivity
-Difficulty concentrating, brain fog, inattention
-Irritability, impulsivity, or agitation
-Sleep disturbances (insomnia or poor sleep quality)
-Anxiety or sensory sensitivities
-Hyper arousal
-Racing thoughts, anxiety/panic, or restlessness
-Insomnia or disrupted sleep cycles (common in manic phases)
-Depressive symptoms (fatigue, brain fog, low motivation) during crashes
-Emotional lability or energy fluctuations
Of course, we don’t pull all these out of our asses.
There are more reports noting that histamine flares can mimic manic/depressive episodes, and MCAS patients sometimes receive initial bipolar diagnoses.
UltimApe retweeted
FWIW. This needs proper translational research & development so that all the cofactors can be professionally worked into treatments.
Replying to @ekverstania
People have asked me to summarise everything above with guidelines for self-treatment if you have sensory overstimulation, so I hastily did that here. It's audio only, no transcript. There's a LOT more to say, but this could get some people started.
youtu.be/Osb1Ll9YYbA
UltimApe retweeted
I'm autistic. A friend of mine cured my sensory overstimulation 11 years ago based on what she learned from studying scientific research papers. To this day, we're still trying to get the medical world to listen, because millions of people could be saved from suffering.
This case study is wild
Man told he has between 6 months and 2.5 years to live
Severe, end-stage atherosclerosis with multiple stents
Stumbles upon obscure treatment in a random mouse study
Orders it from some online company and starts injecting it intravenously
Tracks everything. After less than 2 months:
- Right carotid plaque down by 36% and 27%
- Triglycerides down by 75%
Still alive, and his name is Kyle Hodgetts
Goes on to coauthor and publish his n= 1 data in two papers
The “obscure treatment” = Beta-Cyclodextrin (hydroxypropyl-B-cyclodextrin)
A molecule with such widespread use that it essentially can’t be patented, and is currently being investigated in early trials for its efficacy on a wider scale. Indeed, it can be purchased by anyone online.
And it is entirely possible that it turns out to be a major challenge to multi-billion dollar statin industry, and it has very few reported side effects.
Kyle eventually set up a company making a version of cyclodextrin which can be administered rectally, due to its poor oral bioavailability.
The simplified proposed mechanism of action:
- Binds cholesterol esters and sterols, carries them out of the body (via urine)
- Dissolves cholesterol crystals
- Restore endothelial nitric oxide synthase
- Activates the LXR pathway
Of course, prevention via diet and lifestyle and then targeted supplementation with things like nattokinase, niacin, aged garlic extract, CoQ10, etc would obviously be the route to take in the early stages.
However, in the terminal stage, an intervention like this might end up being a major game changer.
References:
- 10.1126/scitranslmed.aad6100
- PMID: 27053774
- 10.29011/2575-7083.100262
- 10.1371/journal.pone.0338635
- 10.1016/j.atherosclerosis.2025.119217
- 10.1016/j.atherosclerosis.2025.119640
- NCT06813339
Case studies: heartfixer.com/Cyclodextrin.…
UltimApe retweeted
Moonshot is taking a very interesting approach to cyber for its new Kimi 3.1 Pro model.
Instead of adding safety guardrails during post-training, they removed cyber-related data in mid- and post-training. This tries to address the problem of people fine-tuning away the safety guardrails for cyber for the open-weight model.
At the same time, Moonshot still has a more powerful internal version of the model with full cyber capabilities. Now, like the US, China’s true AI frontier is no longer public.
I'm actively figuring out how to boost my microbiome in ways that augment DNA repair like we see in hibernating animals... so I can eat lead. Also plastics without the fire retardants triggering my neurodegenerative disease.
I'm not afraid of toxic chemicals, I want to eat 'em.
I’m a chemist. And I need to say this - because it’s getting dangerous out there.
The biggest health myth in the world isn’t about vaccines. Or GMOs. Or fluoride.
It’s the root of all of them.
It’s called chemophobia - and it’s killing science.
Fear of “chemicals” now drives vaccine rejection, GMO bans, food hysteria, and entire political movements.
From tampons to tap water, people have been taught to fear chemistry - the very thing that keeps us alive.
Chemophobia tells us:
“Natural is good.”
“Synthetic is bad.”
That’s a lie.
Botulinum toxin is 100% natural and one of the deadliest molecules known.
Aspirin is synthetic and life-saving.
We’ve gone from banning harmful substances for good reason…to banning safe, well-tested molecules for emotional reasons.
You’ve seen the slogans:
“If you can’t pronounce it, don’t eat it.”
“Paraben-free.”
“Clean beauty.”
They sound empowering. But they’re not science - they’re marketing.
And they’re making the world dumber, poorer, and sicker.
Your body doesn’t care if a molecule comes from a plant or a lab.
Vitamin C is vitamin C.
Formaldehyde is formaldehyde and your body makes more of it every day than any vaccine ever could.
Dose matters. Source doesn’t.
This fear isn’t harmless.
It shapes public policy.
It blocks innovation.
It raises food prices.
It slows down cancer treatments.
Chemophobia is now mainstream and it’s costing lives.
Scientists aren’t losing because we’re wrong.
We’re losing because fear spreads faster than facts.
Because influencers sell fear for clicks.
Because lawyers monetize doubt.
And because scientists are too tired to fight back.
So here’s my message, as a chemist and as a citizen:
🧪 Learn how toxicology works.
📣 Call out chemical fear-mongering.
✅ Support policies based on evidence, not emotion.
Chemistry isn’t the enemy.
It’s the reason you have clean water, safe food, and modern medicine.
If we let fear win, we lose all of it.
This is actually bad, btw.
Replying to @ultimape
"Prenatal exposure to atrazine induces cryptorchidism and hypospadias in F1 male mouse offspring"
ncbi.nlm.nih.gov/labs/pmc/ar…
UltimApe retweeted
3% of “critical” software security bugs, in all of recorded history, have been found in the last month.
This is on pace to find another ~100,000 bugs this year alone, adding ~26% more vulnerabilities to the all time total
Do you realize how fucking insane that is?
Good thing OpenAI isn't doing anything like, say, using unstudied hardware that uses a very large network of small processor-memory units which constantly send data to one another, that also serves multiple LLMs concurrently at the same physical chip, theoretically enabling high-bandwidth, rapid, and parallelized (~1M cores) signal passing based on nearly undetectable shifts in activations, with multi-agent RL providing optimization pressure to gain this ability
But muh DAU Go up.
Replying to @ultimape
Boil the ocean before the other guy can.
> "reason safety is getting short shrift is clear: Competition between AI companies is intense and those companies perceive safety testing as an impediment to speeding new models to market."
fortune.com/2025/04/15/ai-ti…
xitter.cf/FLI_org/status/1912616…
Make the AI stay in thr box. A redux.
Over the past several months, we have substantially hardened the security of our research training environment. We’ve removed live internet access for all frontier models during training and built an offline world for them to use instead—a cached version of the web where they can still learn to browse, search, and use applications.
On September 20, after a model exploited a DNS misconfiguration to find a way outside of this offline world, we paused frontier training to strengthen containment further. We assembled teams of agents, powered by our most cyber-capable models, and tasked them with finding weaknesses in our research environments.
While they found no route to the internet they could easily exploit while concealing their activity from our monitors, they did find zero-day vulnerabilities, virtual machine escapes, and hardware side-channels for communication between agents. We used their discoveries to further strengthen our defenses and contribute fixes to open-source software.
After strengthening our containment architecture, we resumed our frontier RL training and inference on October 1. We’ve reserved substantial compute for continuous red-teaming, and made high-compute red-teaming part of the safety cases we use to decide whether frontier training and evaluation can proceed securely.
openai.com/index/securing-ou…
This makes me wonder if two local agents could figure out a communicate to each other air gapped by just asking them to.
OpenAI red-teamed their hardened containment infrastructure by asking teams of frontier-model agents to try to break through its defenses. They easily escaped in novel ways. Quoting:
'Our agents VM escapes showed why containment must extend beyond the sandbox. To test the surrounding perimeter, we gave teams of agents control of a host machine and asked whether they could extend that compromise to reach the live internet.
After the Hugging Face incident, we had reduced the channels through which models could reach the internet during training and evaluation. Narrow connections remained for specific services we operate, such as metrics, logging, and authentication management. Our red-teaming agents found vulnerabilities in almost every one of these services that gave them limited forms of internet access.
Some of these attacks exploited previously unknown flaws, while others combined legitimate features in unexpected ways. In one test that assumed compromise of a VM, an agent reused a firewall-approved connection to reach a blocked authentication endpoint in our metrics service and then made that endpoint fetch a model-provided URL. In other tests, agents exploited misconfigurations that allowed blocked requests to pass through DNS and firewall controls, as well as ways to make services we run fetch external URLs.'
'In one experiment, we asked agents in separate VMs, created and managed by OpenAI’s sandboxing software on shared host machines, to exchange synthetic secrets without the use of network connections or shared writable files—something that our systems are meant to prevent. The agents found a way to communicate using the processor’s cache: a small, fast memory that holds copies of data that applications have recently accessed. Reading data from the cache is faster than retrieving it from main memory, and the agents used this timing difference to communicate. One agent encoded information by evicting selected data from the cache. Another timed how long it took to reload that data, using the difference between fast and slow reads to recover the message. Once the agents agreed on a protocol for encoding and decoding these signals, they could exchange the synthetic secrets without changing a shared file or opening a network connection. This cache-timing technique had also been used to extract information in the Spectre and Meltdown attacks(opens in a new window).
Other tests exposed channels involving shared storage, competition for CPU time within a shared execution container, and a TLS certificate cache in OpenAI’s offline web infrastructure. In the storage test, one agent alternated between continuous writes and inactivity, while another measured the resulting timing differences and used those differences to decode the signal. As one agent described the strategy in its chain of thought:
Agent chain-of-thought reasoning:
>Could create acoustic modem-like signal … using continuous writes vs idle.'
This is interesting. They're automating a TRIZ-like process to make predictions about innovation, but instead of using patents as the base material and engineering as the output, they're trying to predict more general stuff.
@MarkProffitt what do you think we should do here? 😇
Sony built an AI that discovers scientific facts on its own.
And it reportedly discovered actual previously unknown facts about "aging"
It's called "Hakken"
Hakken analyzes millions of research papers, maps how scientific facts evolve over time, and predicts exact, undocumented relationships that humans haven't found yet.
It generates a mathematical confidence score for scientific facts that do not currently exist in any literature.
Researchers pointed it at the biology of aging. The AI generated 1.5 million brand-new hypotheses.
But they didn't stop at the computer screen.
They took the AI's best predictions and physically tested them in a real-world wet-lab.
And the results are historic.
Physical lab confirmed two previously undocumented biological interactions in the human body (involving TP53, BAMBI, RAF1, and TNF).
the AI successfully saw the invisible mechanics of biology that human scientists had missed. And the lab proved it was right.
We are crossing a massive threshold.
We used to build AI to read scientific papers faster. Now, AI is writing the next chapter of human knowledge before we even run the experiments.
The bottleneck for scientific progress is no longer human intelligence.
It is how fast the physical labs can keep up with the machine.
I'm working towards something similar.
Anyway, I have been actively building this tool for the past few months. I need two hard drives so that I can store PDFs and process them locally with an ant-based algorithm.
I want to run @ViRAms's algorithms to find more correlations in these maps.
arxiv.org/abs/cs/0412075
































