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Arendt Lab

@wormduty

Lab of Detlev Arendt, tweets by *any* of the lab members. Working to understand cell type evolution with the weirdest beasties we can find!

 Heidelberg, Germany
Joined July 2019
  • Tweets125
  • Following119
  • Followers1.4K
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Photo by Arendt Lab (@wormduty)Photo by Arendt Lab (@wormduty)Photo by Arendt Lab (@wormduty)Photo by Arendt Lab (@wormduty)Photo by Arendt Lab (@wormduty)Photo by Arendt Lab (@wormduty)Photo by Arendt Lab (@wormduty)Photo by Arendt Lab (@wormduty)Photo by Arendt Lab (@wormduty)Photo by Arendt Lab (@wormduty)
biorxiv.org/content/10.1101/… Did you know that sponges can move? @FabianRuperti with @savitski_lab and @Prevedel_lab studied sponge movement and found an evolutionary ancient mechanism controlling cellular tension and defense which is also present in our vasculature! A thread 🧵:
Molecular profiling of sponge deflation reveals an ancient relaxant-inflammatory response

Molecular profiling of sponge deflation reveals an ancient relaxant-inflammatory response

A hallmark of animals is the coordination of whole-body movement. Neurons and muscles are central to this, yet coordinated movements also exist in sponges that lack these cell types. Sponges are...

biorxiv.org
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A genome resource for the marine annelid Platynereis dumerilii biorxiv.org/content/10.1101/…
A genome resource for the marine annelid Platynereis dumerilii

A genome resource for the marine annelid Platynereis dumerilii

The marine annelid Platynereis dumerilii is a model organism used in many research areas including evolution and development, neurobiology, ecology and regeneration. Here we present the genomes of P....

biorxiv.org
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Happy to announce our new preprint on the ancestry of cell adhesion and self-recognition in animals! We used proteomics and structure-based searches to re-examine the Aggregation Factor from the classical sponge mode first studied by Henry Wilson in 1907! doi.org/10.1101/2024.04.19.5…
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Arendt Lab retweeted
EMBL (@embl) profile picture
EMBL@embl25 Jan 2024
Sponges lack muscles & neurons. Yet, they move. How? EMBL Heidelberg Arendt Group @wormduty, @savitski_lab, @Prevedel_Lab & others, showed that sponge movement relies on an ancient relaxant-inflammatory response also found in vertebrate vascular systems. embl.org/news/science/ancien…
An oval light blue shape. In the central part, there is a smaller a red object, from which stem many highly branched smaller canals that cover a significant part of the blue surface. The whole sponge image is in placed in a circle. The background around the circle is blue-green.

ALT An oval light blue shape. In the central part, there is a smaller a red object, from which stem many highly branched smaller canals that cover a significant part of the blue surface. The whole sponge image is in placed in a circle. The background around the circle is blue-green.

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Our story about relaxing sponges is out today in @CurrentBiology! 🧽 For a concise summary, check out the thread below 👇 cell.com/current-biology/ful…
Molecular profiling of sponge deflation reveals an ancient relaxant-inflammatory response

Molecular profiling of sponge deflation reveals an ancient relaxant-inflammatory response

The evolution of coordinated behavior in early animals is largely obscure. Ruperti et al. uncover that sponge movement is driven by actomyosin stress fiber relaxation, regulated by Akt/NO/PKG/PKA....

cell.com
Arendt Lab (@wormduty) profile pictureArendt Lab@wormduty3 Aug 2023
biorxiv.org/content/10.1101/… Did you know that sponges can move? @FabianRuperti with @savitski_lab and @Prevedel_lab studied sponge movement and found an evolutionary ancient mechanism controlling cellular tension and defense which is also present in our vasculature! A thread 🧵:
Molecular profiling of sponge deflation reveals an ancient relaxant-inflammatory response

Molecular profiling of sponge deflation reveals an ancient relaxant-inflammatory response

A hallmark of animals is the coordination of whole-body movement. Neurons and muscles are central to this, yet coordinated movements also exist in sponges that lack these cell types. Sponges are...

biorxiv.org
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The ocean 🌊 in us: The maintenance of laminar flow is essential for both - sponge canal and vertebrate vascular system  Any deviation leads to the activation of this ancient conserved ‘relaxant-inflammatory’ response as a powerful defense reaction 🛡️.
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Many thanks to all the authors for this wonderful collaboration and additionally to: -@SANICHOLS_DU and @diz_lab for the great feedback -@althonos and @galicae for the support in python coding -@itn_ignite and @embl EIPP for funding @FabianRuperti
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